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公开(公告)号：US11623096B2
公开(公告)日：2023-04-11
申请号：US16945624
申请日：2020-07-31
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Scott R. Stanslaski , Jadin C. Jackson , Christopher L. Pulliam , Eric J. Panken , Michelle A. Case , Abbey Beuning Holt Becker
Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
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公开(公告)号：US20220126100A1
公开(公告)日：2022-04-28
申请号：US17077805
申请日：2020-10-22
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Abbey Beuning Holt Becker
Abstract: This disclosure is directed to devices, systems, and techniques for determining one or more phase relationships. A medical device system includes a memory and processing circuitry in communication with the memory. The processing circuitry is configured to receive a plurality of electrical signals which indicate a phase relationship between two or more tissue regions within a target area of neural tissue of a patient. Additionally, the processing circuitry is configured to determine, based on the plurality of electrical signals, the phase relationship between the two or more tissue regions, and compare the phase relationship with a target phase relationship for the two or more tissue regions within the target area. The processing circuitry is further configured to determine, based on the comparison, one or more parameters of stimulation for delivery to the patient and cause a therapy delivery circuit to determine the stimulation.
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公开(公告)号：US20220096842A1
公开(公告)日：2022-03-31
申请号：US17036957
申请日：2020-09-29
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Alan Shi
Abstract: A stimulation therapy system dynamically modifies therapy intensity based on measured neurotransmitter levels. In some examples, the system delivers, via an electrode implanted in a brain of a patient and stimulation circuitry, an electrical stimulus; monitors an electrical current generated by the stimulation circuitry to deliver the electrical stimulus; determines, based on the electrical current, a value representative of a concentration of dopamine in the brain of the patient; determines, based on the value representative of the concentration of dopamine, a value for one or more stimulation parameters that at least partially define electrical stimulation therapy; and delivers, via the electrode, the electrical stimulation therapy.
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公开(公告)号：US20220032063A1
公开(公告)日：2022-02-03
申请号：US16945624
申请日：2020-07-31
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Scott R. Stanslaski , Jadin C. Jackson , Christopher L. Pulliam , Eric J. Panken , Michelle A. Case , Abbey Beuning Holt Becker
Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
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公开(公告)号：US20210251525A1
公开(公告)日：2021-08-19
申请号：US17176976
申请日：2021-02-16
Applicant: Medtronic, Inc.
Inventor： David Probst , Randal Schulhauser , Patrick W. Kinzie , Jadin C. Jackson , Daniel Hahn
IPC: A61B5/1468 , A61B5/00 , A61N1/36 , A61N1/05 , A61K31/662 , A61M5/142
Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.
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Patent Agency Ranking
26.发明授权公开(公告)号：US11045652B2
公开(公告)日：2021-06-29
申请号：US16395320
申请日：2019-04-26
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Yizi Xiao , Paula Andrea Elma Dassbach Green , Jianping Wu , Christopher L. Pulliam , Eric J. Panken , Robert S. Raike , Scott R. Stanslaski
Abstract: Techniques are described determining electrodes that are proximate or distal to location of an oscillatory signal source in a patient based on current source densities (CSDs). Processing circuitry may determine, for one or more electrodes of a plurality of electrodes, respective time-varying measurements of CSDs, aggregate, for the one or more electrodes of the plurality electrodes, the respective time-varying measurements of the CSDs to generate respective average level values for the one or more electrodes of the plurality of electrodes, determine, for one or more electrodes of the plurality of electrodes, respective phase-magnitude representations of the time-varying measurements of the CSDs. The respective phase-magnitude representations are indicative of respective magnitudes and phases of a particular frequency component of respective time-varying measurements of the CSDs. The particular frequency component is a frequency component having a largest transform coefficient in a time-varying measurement of a CSD having a largest average level value.
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公开(公告)号：US20180350465A1
公开(公告)日：2018-12-06
申请号：US16057417
申请日：2018-08-07
Applicant: Medtronic, Inc.
Inventor： Robert A. Corey , Gregory J. Loxtercamp , Heather Diane Orser , Scott R. Stanslaski , Jadin C. Jackson
Abstract: Techniques are described for real-time phase detection. For the phase detection, a signal is correlated with a frequency component of a frequency band whose phase is being detected, and the correlation includes predominantly decreasing weighting of past portions of the signals.
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公开(公告)号：US12168133B2
公开(公告)日：2024-12-17
申请号：US18298179
申请日：2023-04-10
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Scott R. Stanslaski , Jadin C. Jackson , Christopher L Pulliam , Eric J. Panken , Michelle A. Case , Abbey Beuning Holt Becker
Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
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公开(公告)号：US11975200B2
公开(公告)日：2024-05-07
申请号：US17651500
申请日：2022-02-17
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Rene A. Molina , Christopher L. Pulliam
CPC classification number: A61N1/36192 , A61N1/0534 , A61N1/36135 , A61N1/36164 , A61N1/36171 , A61N1/36175 , A61N1/3727
Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive, for each electrode combination of a plurality of electrode combinations, information representing a signal sensed in response to first electrical stimulation delivered to a patient via a lead, wherein the plurality of electrode combinations comprise different electrode combinations comprising electrode disposed at different positions around a perimeter of the lead implanted in the patient. The system may also be configured to determine, based on the information for each electrode combination of the plurality of electrode combinations, values for a threshold at different locations around the perimeter of the lead and determine, based on the values for the threshold, one or more stimulation parameter values that at least partially define second electrical stimulation deliverable to the patient via the lead.
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公开(公告)号：US20230241400A1
公开(公告)日：2023-08-03
申请号：US18298179
申请日：2023-04-10
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Scott R. Stanslaski , Jadin C. Jackson , Christopher L. Pulliam , Eric J. Panken , Michelle A. Case , Abbey Beuning Holt Becker
CPC classification number: A61N1/36139 , A61N1/36135 , A61N1/36067 , A61N1/36171 , A61N1/0534 , A61N1/3615
Abstract: Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
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