公开(公告)号：US11589785B2

公开(公告)日：2023-02-28

申请号：US17176976

申请日：2021-02-16

Applicant: Medtronic, Inc.

Inventor： David Probst ,  Randal Schulhauser ,  Patrick W. Kinzie ,  Jadin C. Jackson ,  Daniel Hahn

IPC: A61B5/1468 ,  A61B5/00 ,  A61N1/05 ,  A61K31/662 ,  A61M5/142 ,  A61N1/36

Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.

公开(公告)号：US20220176026A1

公开(公告)日：2022-06-09

申请号：US17541736

申请日：2021-12-03

Applicant: Medtronic, Inc. ,  Bellco S.r.l.

Inventor： Vijaya Kumar Parari ,  Christopher M. Hobot ,  Kaustubh R. Patil ,  Fabrizio Puviani ,  Daniel Hahn

IPC: A61M1/28 ,  F16L1/06

Abstract: A flexible pipe routing accessory for routing a flexible tube between a preparator and an automatic cycler of a peritoneal dialysis system, comprising: a guide pipe through which the flexible tube is to be routed; a guide wire configured to pass through the guide pipe and selectively connect to the flexible tube; and a winding mechanism configured to move the guide wire through the guide pipe.

公开(公告)号：US20200072782A1

公开(公告)日：2020-03-05

申请号：US16116306

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: G01N27/327

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

公开(公告)号：US10852268B2

公开(公告)日：2020-12-01

申请号：US16116306

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: G01N27/327 ,  G01N33/483

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

公开(公告)号：US20200069226A1

公开(公告)日：2020-03-05

申请号：US16116346

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/145 ,  A61B5/053

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US20230404446A1

公开(公告)日：2023-12-21

申请号：US18460271

申请日：2023-09-01

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145

CPC classification number: A61B5/1468 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US20210251525A1

公开(公告)日：2021-08-19

申请号：US17176976

申请日：2021-02-16

Applicant: Medtronic, Inc.

Inventor： David Probst ,  Randal Schulhauser ,  Patrick W. Kinzie ,  Jadin C. Jackson ,  Daniel Hahn

IPC: A61B5/1468 ,  A61B5/00 ,  A61N1/36 ,  A61N1/05 ,  A61K31/662 ,  A61M5/142

Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.

公开(公告)号：US20240268721A1

公开(公告)日：2024-08-15

申请号：US18626074

申请日：2024-04-03

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Akhil Srinivasan ,  Patrick W. Kinzie ,  Randal C. Schulhauser ,  Jennifer L. Marckmann ,  Mohsen Askarinya ,  James K. Carney ,  David L. Probst ,  Santhisagar Vaddiraju ,  Alejo Chavez Gaxiola ,  Richard J. O'Brien ,  Anna M. Tycon ,  Omid Mahdavi ,  Shawn C. Kelley ,  David A. Anderson

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/30 ,  G01N27/327

CPC classification number: A61B5/1468 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  G01N27/301 ,  G01N27/3271

Abstract: Techniques are disclosed for measuring an analyte in a biological system. A system may include a medical device with an electrochemical sensor configured to sense the concentration of a plurality of analytes present in a biological system. Processing circuitry of the system may retrieve, identify, and process a respective signal from a respective work electrode to determine the concentration of a respective analyte. The system may further include an implantable medical device configured to sense a cardiac electrogram (EGM). In some examples, the system may be configured to determine one or more patient-specific relationships between the respective signals of the electrochemical sensor and the cardiac EGM during a first period of time. Based on the patient-specific relationships, the system may estimate concentrations of the one or more analytes corresponding to the respective signals based on the cardiac EGM of the patient collected over a second period of time.

公开(公告)号：US20200038671A1

公开(公告)日：2020-02-06

申请号：US16050928

申请日：2018-07-31

Applicant: Medtronic, Inc.

Inventor： Randal C. Schulhauser ,  Jian Cao ,  David Probst ,  Daniel Hahn ,  Eric C. Maass ,  Patrick W. Kinzie

IPC: A61N1/39 ,  A61N1/04 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0476 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11

Abstract: In some examples, an apparatus configured to be worn by a patient for cardiac defibrillation comprises sensing electrodes configured to sense a cardiac signal of the patient, defibrillation electrodes, therapy delivery circuitry configured to deliver defibrillation therapy to the patient via the defibrillation electrodes, communication circuitry configured to receive data of at least one physiological signal of the patient from at least one sensing device separate from the apparatus, a memory configured to store the data, the cardiac signal, and a machine learning algorithm, and processing circuitry configured to apply the machine learning algorithm to the data and the cardiac signal to probabilistically-determine at least one state of the patient and determine whether to control delivery of the defibrillation therapy based on the at least one probabilistically-determined patient state.

公开(公告)号：US12138050B2

公开(公告)日：2024-11-12

申请号：US18460271

申请日：2023-09-01

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/30 ,  G01N27/327

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.