公开(公告)号：US20230404446A1

公开(公告)日：2023-12-21

申请号：US18460271

申请日：2023-09-01

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145

CPC classification number: A61B5/1468 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US20210251525A1

公开(公告)日：2021-08-19

申请号：US17176976

申请日：2021-02-16

Applicant: Medtronic, Inc.

Inventor： David Probst ,  Randal Schulhauser ,  Patrick W. Kinzie ,  Jadin C. Jackson ,  Daniel Hahn

IPC: A61B5/1468 ,  A61B5/00 ,  A61N1/36 ,  A61N1/05 ,  A61K31/662 ,  A61M5/142

Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.

公开(公告)号：US11589785B2

公开(公告)日：2023-02-28

申请号：US17176976

申请日：2021-02-16

Applicant: Medtronic, Inc.

Inventor： David Probst ,  Randal Schulhauser ,  Patrick W. Kinzie ,  Jadin C. Jackson ,  Daniel Hahn

IPC: A61B5/1468 ,  A61B5/00 ,  A61N1/05 ,  A61K31/662 ,  A61M5/142 ,  A61N1/36

Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.

公开(公告)号：US20200072782A1

公开(公告)日：2020-03-05

申请号：US16116306

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: G01N27/327

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

公开(公告)号：US20200038671A1

公开(公告)日：2020-02-06

申请号：US16050928

申请日：2018-07-31

Applicant: Medtronic, Inc.

Inventor： Randal C. Schulhauser ,  Jian Cao ,  David Probst ,  Daniel Hahn ,  Eric C. Maass ,  Patrick W. Kinzie

IPC: A61N1/39 ,  A61N1/04 ,  A61B5/00 ,  A61B5/145 ,  A61B5/0476 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11

Abstract: In some examples, an apparatus configured to be worn by a patient for cardiac defibrillation comprises sensing electrodes configured to sense a cardiac signal of the patient, defibrillation electrodes, therapy delivery circuitry configured to deliver defibrillation therapy to the patient via the defibrillation electrodes, communication circuitry configured to receive data of at least one physiological signal of the patient from at least one sensing device separate from the apparatus, a memory configured to store the data, the cardiac signal, and a machine learning algorithm, and processing circuitry configured to apply the machine learning algorithm to the data and the cardiac signal to probabilistically-determine at least one state of the patient and determine whether to control delivery of the defibrillation therapy based on the at least one probabilistically-determined patient state.

公开(公告)号：US10852268B2

公开(公告)日：2020-12-01

申请号：US16116306

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: G01N27/327 ,  G01N33/483

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a plurality of respective work electrodes. Each respective work electrode of the plurality of respective work electrodes may be electrically coupled to the common reference electrode and include a respective reagent substrate configured to react with a respective analyte to produce a signal indicative of a concentration of the respective analyte.

公开(公告)号：US20200069226A1

公开(公告)日：2020-03-05

申请号：US16116346

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/145 ,  A61B5/053

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US12138050B2

公开(公告)日：2024-11-12

申请号：US18460271

申请日：2023-09-01

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/30 ,  G01N27/327

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US11744492B2

公开(公告)日：2023-09-05

申请号：US16116346

申请日：2018-08-29

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Mohsen Askarinya ,  James K. Carney ,  Patrick W. Kinzie ,  Jennifer Lorenz Marckmann ,  Randal C. Schulhauser ,  Santhisagar Vaddiraju ,  Akhil Srinivasan ,  David Probst ,  Alejo Chavez Gaxiola

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/30 ,  G01N27/327

CPC classification number: A61B5/1468 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  G01N27/301 ,  G01N27/3271

Abstract: A biocompatible medical device may include an electrochemical sensor including a common reference electrode; at least one counter electrode; and a work electrode platform comprising a plurality of respective work electrodes, each respective work electrode electrically coupled to the common reference electrode and comprising a respective reagent substrate configured to react with a respective analyte to produce a respective signal indicative of a concentration of the respective analyte; and processing circuitry operatively coupled to the electrochemical sensor, and configured to receive from the electrochemical sensor a plurality of signals from the plurality of respective work electrodes; identify the respective signal corresponding to a respective selected work electrode; and process the identified signal to determine the concentration of the respective analyte associated with the respective selected work electrode.

公开(公告)号：US20230201612A1

公开(公告)日：2023-06-29

申请号：US18178423

申请日：2023-03-03

Applicant: Medtronic, Inc.

Inventor： Randal C. Schulhauser ,  Jian Cao ,  David Probst ,  Daniel Hahn ,  Eric C. Maass ,  Patrick W. Kinzie

IPC: A61N1/39 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11 ,  A61B5/145 ,  A61N1/04 ,  A61B5/369

CPC classification number: A61N1/3904 ,  A61B5/0031 ,  A61B5/021 ,  A61B5/024 ,  A61B5/08 ,  A61B5/11 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/7275 ,  A61N1/046 ,  A61B5/369

Abstract: In some examples, an apparatus configured to be worn by a patient for cardiac defibrillation comprises sensing electrodes configured to sense a cardiac signal of the patient, defibrillation electrodes, therapy delivery circuitry configured to deliver defibrillation therapy to the patient via the defibrillation electrodes, communication circuitry configured to receive data of at least one physiological signal of the patient from at least one sensing device separate from the apparatus, a memory configured to store the data, the cardiac signal, and a machine learning algorithm, and processing circuitry configured to apply the machine learning algorithm to the data and the cardiac signal to probabilistically-determine at least one state of the patient and determine whether to control delivery of the defibrillation therapy based on the at least one probabilistically-determined patient state.