公开(公告)号：US20060127443A1

公开(公告)日：2006-06-15

申请号：US11007877

申请日：2004-12-09

Applicant: Michael Helmus

Inventor： Michael Helmus

IPC: A61F2/06

CPC classification number: B82Y30/00 ,  A61L27/20 ,  A61L27/28 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/608 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/375

Abstract: The present invention is directed to medical devices which comprise the following: (a) an underlying region that comprises a therapeutic agent and (b) a vapor deposited nanoporous coating (e.g., a polymeric, ceramic or metallic nanoporous coating) over the underlying region, which regulates the release of the therapeutic agent from the medical device when it is placed into a subject.

Abstract translation: 本发明涉及包括以下的医疗器械：（a）包含治疗剂的下层区域和（b）在下面区域上的气相沉积纳米多孔涂层（例如，聚合物，陶瓷或金属纳米多孔涂层） 其调节当治疗剂放入受试者时从医疗装置释放治疗剂。

公开(公告)号：US20060089709A1

公开(公告)日：2006-04-27

申请号：US10970264

申请日：2004-10-21

Applicant: Michael Helmus

Inventor： Michael Helmus

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/0077 ,  A61F2/915 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2250/0001 ,  A61F2250/0067 ,  A61N1/32

Abstract: A medical device for implantation into a host organism is disclosed. The device comprises a surface adapted for contact with body tissue of the host organism and an electrode disposed on at least a portion of the surface. Also the device comprises a power source in direct or indirect electrical communication with the electrode. The power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue or create other desired biological effects.

Abstract translation: 公开了用于植入宿主生物体的医疗装置。 该装置包括适于与宿主生物体的身体组织接触的表面和设置在表面的至少一部分上的电极。 该装置还包括与电极直接或间接电连通的电源。 电源能够向电极提供电流以在表面上产生有效促进表面与身体组织的生物相容性或产生其他期望的生物效应的平均表面电荷密度。

公开(公告)号：US20050240098A1

公开(公告)日：2005-10-27

申请号：US10826960

申请日：2004-04-15

Applicant: Sheng-Ping Zhong ,  Michael Helmus ,  Scott Smith ,  Bruce Hammer

Inventor： Sheng-Ping Zhong ,  Michael Helmus ,  Scott Smith ,  Bruce Hammer

IPC: G01R33/28 ,  A61B5/05

CPC classification number: G01R33/285

Abstract: Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.

Abstract translation: 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。

公开(公告)号：US20050238684A1

公开(公告)日：2005-10-27

申请号：US10830772

申请日：2004-04-23

Applicant: Michael Helmus ,  Shrirang Ranade

Inventor： Michael Helmus ,  Shrirang Ranade

IPC: A61F2/00 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L29/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  A61L2400/18

Abstract: Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between 20 and 30 dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced throboresistance, relative to other surfaces.

Abstract translation: 可植入或可插入的医疗装置包括通过共价地将分子种类（或分子种类的组合）共价连接到其上的表面区域。 选择分子种类，使得所得到的改性表面区域具有20至30达因/厘米的临界表面能。 在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。 本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已被证明显示出增强的生物相容性，包括相对于其它表面增强的阻抗。

公开(公告)号：US20050208107A1

公开(公告)日：2005-09-22

申请号：US10801228

申请日：2004-03-16

Applicant: Michael Helmus ,  Barron Tenney

Inventor： Michael Helmus ,  Barron Tenney

IPC: A61L27/16 ,  D01F6/30 ,  D01F6/42 ,  A61F2/06 ,  A61K9/70

CPC classification number: D01F6/30 ,  D01F6/42 ,  Y10T442/2525

Abstract: According to an aspect of the present invention, a fiber comprising a styrene-isobutylene copolymer is formed by via a dry spinning process. Specific examples of copolymers for the practice of the present invention include copolymers comprising a polyisobutylene block and a polystyrene block, for instance, a polystyrene-polyisobutylene-polystyrene triblock copolymer. Other aspects of the present invention relate to medical articles which comprise the above dry spun fibers. Specific examples include medical articles comprising a woven region formed from the dry spun fibers, and medical articles comprising a non-woven region formed from the dry spun fibers.

Abstract translation: 根据本发明的一个方面，通过干法纺丝法形成包含苯乙烯 - 异丁烯共聚物的纤维。 用于实施本发明的共聚物的具体实例包括包含聚异丁烯嵌段和聚苯乙烯嵌段的共聚物，例如聚苯乙烯 - 聚异丁烯 - 聚苯乙烯三嵌段共聚物。 本发明的其它方面涉及包含上述干纺纤维的医疗制品。 具体实例包括包含由干燥纺丝纤维形成的织造区域的医疗制品和包含由干燥纺丝纤维形成的无纺织物区域的医疗制品。

公开(公告)号：US20050187611A1

公开(公告)日：2005-08-25

申请号：US11116256

申请日：2005-04-27

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61K9/00 ,  A61K47/32 ,  A61K47/34 ,  A61L27/00 ,  A61L27/22 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/10 ,  A61M37/00 ,  A61F2/06

CPC classification number: A61L33/0011 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/08 ,  C08L71/02 ,  C08L5/00 ,  C08L83/00 ,  C08L83/04

Abstract: A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed herein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

Abstract translation: 公开了用于涂覆可植入装置或假体的涂层和方法。 该涂层包括聚合材料的底涂层，其含有一定量的生物活性材料，特别是在此分散的肝素。 涂层还包括覆盖低于底涂层整个表面的面漆，并且其中面漆包含基本上不含孔隙和孔隙体的聚合材料。 面漆的聚合材料可以是生物稳定的生物相容性材料，其在生物活性材料释放过程中和之后提供了对器件部分的长期非血栓形成。