公开(公告)号：US20060171980A1

公开(公告)日：2006-08-03

申请号：US11048147

申请日：2005-02-01

Applicant: Michael Helmus ,  Paul Valint ,  Shrirang Ranade

Inventor： Michael Helmus ,  Paul Valint ,  Shrirang Ranade

IPC: A61F13/00

CPC classification number: A61L27/26 ,  A61L27/50

Abstract: An implantable or insertable medical device is provided that contains at least one polymeric region which comes into contact with a subject upon implantation or insertion of the device into the subject. The polymeric region(s) contain at least one bulk polymer moiety and at least one surface-active polymer moiety that (a) is covalently attached to the bulk polymer moiety/moieties or admixed with the bulk polymer moiety/moieties and (b) is provided in an amount that is effective in providing the polymeric region(s) with a critical surface energy that is between 20 dynes/cm and 30 dynes/cm upon implantation or insertion of the device into the subject.

Abstract translation: 提供了一种可植入或可插入的医疗装置，其包含至少一个聚合物区域，该聚合物区域在将装置植入或插入受试者时与受试者接触。 聚合物区域包含至少一个本体聚合物部分和至少一个表面活性聚合物部分，（a）共价连接到本体聚合物部分/部分或与本体聚合物部分/部分混合，（b） 提供的量可以有效地在聚合物区域植入或插入到受试者中时提供在20达因/厘米至30达因/厘米之间的临界表面能。

公开(公告)号：US20060089705A1

公开(公告)日：2006-04-27

申请号：US11296764

申请日：2005-12-06

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F2/90

CPC classification number: A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/236 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/606 ,  C08L83/04

Abstract: The present invention is directed to an expandable stent for implantation in a patient comprising a tubular metal body having open ends and a sidewall structure having openings therein and a coating disposed on a surface of said sidewall structure, said coating comprising a hydrophobic biostable elastomeric material and a biologically active material, wherein said coating continuously conforms to said structure in a manner that preserves said openings.

公开(公告)号：US20060030936A1

公开(公告)日：2006-02-09

申请号：US10914012

申请日：2004-08-05

Applicant: Jan Weber ,  Gordon Kocur ,  Michael Helmus ,  Maria Palasis

Inventor： Jan Weber ,  Gordon Kocur ,  Michael Helmus ,  Maria Palasis

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2250/0068 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

Abstract: Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at least one pocket containing a biologically active material are disclosed. The composition may be injected using a nanometer- or micrometer-sized needle. Methods for making such medical devices are also disclosed. Using this method, a precise amount of the biologically active material may be disposed accurately and efficiently on the medical device at predefined locations.

公开(公告)号：US20070280987A1

公开(公告)日：2007-12-06

申请号：US11442773

申请日：2006-05-30

Applicant: Michael Helmus ,  Paul Valint ,  Shrirang Ranade

Inventor： Michael Helmus ,  Paul Valint ,  Shrirang Ranade

IPC: A61K38/08 ,  A61K38/06 ,  A61K38/05 ,  C08G63/91 ,  A61K31/727

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/236 ,  A61L2300/25

Abstract: According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the hydrophilic bioactive portion by a covalent linkage that contains a chain transfer agent residue. According to another aspect of the present invention, medical articles are provided with bioactive surface by coating them with a coating material that contains such bioactive polymers.

Abstract translation: 根据本发明的一个方面，提供了生物活性聚合物，其具有（a）亲水性生物活性部分和（b）通过含有链转移剂的共价键与亲水生物活性部分连接的至少一个疏水性聚合物基团 残留物 根据本发明的另一方面，通过用包含这种生物活性聚合物的涂层材料涂覆医疗制品来提供生物活性表面。

公开(公告)号：US20070224235A1

公开(公告)日：2007-09-27

申请号：US11388604

申请日：2006-03-24

Applicant: Barron Tenney ,  Yixin Xu ,  Michael Helmus

Inventor： Barron Tenney ,  Yixin Xu ,  Michael Helmus

IPC: A61F2/06

CPC classification number: A61F2/02 ,  A61F2/30767 ,  A61F2/82 ,  A61F2/91 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/3084 ,  A61F2210/0076 ,  A61F2250/0068 ,  A61L29/146 ,  A61L29/16 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  A61N1/375 ,  B82Y30/00

Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含（a）含有至少一种治疗剂的一种或多种凹陷，和（b）在含治疗剂的凹陷上设置的纳米多孔涂层 ，其调节物质在含治疗剂的凹陷和装置的外部之间的运输。 可植入或可插入的装置被配置为预防仅仅药物递送的作用，例如在体内提供机械和/或电功能等功能。 本发明的一个优点是可以提供医疗装置，其释放的量远远超过纳米多孔涂层内的空隙体积，同时提供延伸超出药物递送的功能。 这种释放可以进一步接近或实现零级动力学药物释放曲线。

公开(公告)号：US20060204545A1

公开(公告)日：2006-09-14

申请号：US11079621

申请日：2005-03-14

Applicant: Shrirang Ranade ,  Michael Helmus ,  Robert Richard

Inventor： Shrirang Ranade ,  Michael Helmus ,  Robert Richard

IPC: A61F2/02

CPC classification number: A61L27/50 ,  A61L27/54 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/602

Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.

Abstract translation: 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。 聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。 治疗剂设置在聚合物释放区域的下方或内部。

公开(公告)号：US20060129215A1

公开(公告)日：2006-06-15

申请号：US11007867

申请日：2004-12-09

Applicant: Michael Helmus ,  Yixin Xu ,  Shrirang Ranade

Inventor： Michael Helmus ,  Yixin Xu ,  Shrirang Ranade

IPC: A61N1/05

CPC classification number: B82Y30/00 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/45 ,  A61L2300/624 ,  A61N1/05 ,  B82Y5/00

Abstract: According to certain aspects of the invention, implantable or insertable medical devices are provided that contain one or more nanoporous regions, which may further comprise interconnected nanopores. Other aspects of the invention are directed to implantable or insertable medical devices that contain one or more nanostructured regions, which are formed by a variety of methods. Still other aspects of the invention are directed to implantable or insertable medical devices having nanotextured surface regions, in which cell-adhesion-promoting biomolecules (e.g., glycosaminoglycans, proteoglycans, cell adhesion peptides, and adhesive proteins) are provided on, within or beneath the nanotextured surface regions.

Abstract translation: 根据本发明的某些方面，提供了可植入或可插入的医疗装置，其包含一个或多个纳米多孔区域，其可以进一步包括互连的纳米孔。 本发明的其它方面涉及含有一个或多个纳米结构区域的可植入或可插入的医疗装置，其通过多种方法形成。 本发明的另外其它方面涉及具有纳米纹理表面区域的可植入或可插入的医疗装置，其中提供细胞粘附促进生物分子（例如，糖胺聚糖，蛋白聚糖，细胞粘附肽和粘合蛋白），其中， 纳米纹理表面区域。

公开(公告)号：US20060124466A1

公开(公告)日：2006-06-15

申请号：US11007297

申请日：2004-12-09

Applicant: Yixin Xu ,  Michael Helmus

Inventor： Yixin Xu ,  Michael Helmus

IPC: C25D15/00

CPC classification number: A61L31/10 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/02 ,  C09D5/4492 ,  C25D9/00 ,  C25D9/02 ,  C25D15/00

Abstract: Methods and apparatuses for coating surfaces of medical devices by electroplating are disclosed. In one embodiment, the invention includes a coating method in which a mixture of a therapeutic agent, and a plating material are electroplated onto the surface of the medical device. The electroplating method may be performed at a relatively low temperature to avoid destruction of the therapeutic agent. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in an electrolytic solution and electroplating a plating material onto the medical device wherein the plating material carries the suspended therapeutic agent. Thus, the coating of plating material contains the suspended therapeutic agent. These methods and apparatuses are used to apply one or more coating materials, simultaneously or in sequence by varying the electroplating voltage. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.

Abstract translation: 公开了通过电镀来涂覆医疗装置的表面的方法和装置。 在一个实施方案中，本发明包括将治疗剂和电镀材料的混合物电镀在医疗装置的表面上的涂布方法。 电镀方法可以在相对低的温度下进行以避免治疗剂的破坏。 在另一个实施方案中，公开了一种涂覆方法，其中通过将治疗剂悬浮在电解液中并将电镀材料电镀到医疗装置上而形成涂层，其中电镀材料携带悬浮的治疗剂。 因此，电镀材料的涂层含有悬浮治疗剂。 这些方法和装置用于通过改变电镀电压同时或依次施加一种或多种涂层材料。 在本发明的某些实施方案中，涂层材料包括治疗剂和阳离子药物。

公开(公告)号：US20050080040A1

公开(公告)日：2005-04-14

申请号：US10959549

申请日：2004-10-05

Applicant: Crystal Cunanan ,  Tan Dinh ,  Christine Loshbaugh ,  H. Sarner ,  Michael Helmus

Inventor： Crystal Cunanan ,  Tan Dinh ,  Christine Loshbaugh ,  H. Sarner ,  Michael Helmus

IPC: A61L2/16 ,  A61L27/36 ,  A61K31/737 ,  A61K31/727

CPC classification number: A61L27/3687 ,  A61L2/16

Abstract: The present invention provides methods of inactivating and removing infectious agents from tissues of use in bioprosthetic devices. The methods include the removal and blockage of binding sites on the tissues for the infectious agents. Also provided are methods for blocking a site on an infectious agent that binds to a site on the tissue.

Abstract translation: 本发明提供从生物假体装置中使用的组织中灭活和除去感染因子的方法。 所述方法包括去除和阻断感染剂组织上的结合位点。 还提供了用于阻断结合于组织上的部位的感染剂上的部位的方法。

公开(公告)号：US20070110786A1

公开(公告)日：2007-05-17

申请号：US11274538

申请日：2005-11-15

Applicant: Barron Tenney ,  Michael Helmus

Inventor： Barron Tenney ,  Michael Helmus

IPC: A61K48/00 ,  A61F2/02

CPC classification number: A61L31/10 ,  A61K47/58 ,  A61K47/59 ,  A61K47/60 ,  A61K47/645 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/80 ,  A61L2400/12

Abstract: According to an aspect of the present invention, medical articles are provided which comprise the following (a) a polymeric region having a first charge, and (b) a charged therapeutic agent having a second charge that is opposite in sign to that of the first charge. In certain beneficial embodiments, the medical articles are high surface area articles, for example, articles formed using small diameter (e.g., 10 microns or less) fibers.

Abstract translation: 根据本发明的一个方面，提供了医疗制品，其包括以下（a）具有第一电荷的聚合物区域，和（b）具有与第一电荷符号相反的第二电荷的带电治疗剂 收费。 在某些有益的实施方案中，医疗制品是高表面积制品，例如使用小直径（例如10微米或更小）纤维形成的制品。