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26 条记录 (耗时 0.02 秒)

    Apoptosis inhibitor
    21.
    发明授权
    Apoptosis inhibitor 失效
    凋亡抑制剂

    公开(公告)号：US06399639B1

    公开(公告)日：2002-06-04

    申请号：US09519274

    申请日：2000-03-07

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    摘要翻译： 一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

    Apoptosis inhibitor
    23.
    发明授权
    Apoptosis inhibitor 失效

    公开(公告)号：US06555565B2

    公开(公告)日：2003-04-29

    申请号：US10047816

    申请日：2002-01-15

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    Apoptosis inhibitor
    24.
    发明授权
    Apoptosis inhibitor 有权
    凋亡抑制剂

    公开(公告)号：US6087384A

    公开(公告)日：2000-07-11

    申请号：US272747

    申请日：1999-03-15

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  C07D413/02 ,  C07D413/14 ,  C07D417/02 ,  C07D417/14 ,  A01K31/426 ,  A01K31/427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R.sup.1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R.sup.1 ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    摘要翻译： 一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

    Process for enantioselective hydrolysis of .alpha.-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces
    26.
    发明授权
    Process for enantioselective hydrolysis of .alpha.-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces 失效
    使用芽孢杆菌，假单胞菌或链霉菌的α-（2-氨基）苯基 - 苯甲醇酯型化合物的对映选择性水解方法

    公开(公告)号：US5770438A

    公开(公告)日：1998-06-23

    申请号：US550643

    申请日：1995-10-31

    申请人： Kazuo Nakahama ,  Motowo Izawa ,  Yoichi Nagano ,  Naoki Tarui ,  Kiyoharu Matsumoto ,  Masakuni Kori ,  Tsuneo Kanamaru ,  Toshiaki Nagata

    发明人： Kazuo Nakahama ,  Motowo Izawa ,  Yoichi Nagano ,  Naoki Tarui ,  Kiyoharu Matsumoto ,  Masakuni Kori ,  Tsuneo Kanamaru ,  Toshiaki Nagata

    IPC分类号： C12P7/22 ,  C12P17/10 ,  C12P41/00

    CPC分类号： C12P17/10 ,  C12P41/004 ,  C12P41/005 ,  C12P7/22

    摘要： A process for producing an optically active form of a compound of formula (I) ##STR1## wherein R.sub.1 represents hydrogen or a hydrocarbon group that may be substituted; R.sub.2 and R.sub.3 independently represent hydrogen, a hydrocarbon group that may be substituted, or a heteroaromatic group that may be substituted; X' represents a substituent comprising an esterified carboxyl group or an acylated hydroxyl group; ring A represents a benzene ring that may be substituted or a heteroaromatic ring that may be substituted; ring J' represents a 7- or 8-membered heterocyclic ring containing at most 3 hetero-atoms as ring-constituent members, which may have a further substituent or substituents in addition to R.sub.1, R.sub.2, R.sub.3 and X', and C* denotes a chiral carbon atom or a salt thereof, which comprises subjecting the racemic compound of the formula (I) or a salt thereof, or alternatively a racemic starting compound for synthesizing the compound of the formula (I) to enzymatically enantioselective hydrolysis to provide an optically active form thereof.

    摘要翻译： 一种制备光学活性形式的式（I）化合物的方法其中R 1表示氢或可被取代的烃基; R2和R3独立地表示氢，可以被取代的烃基或可以被取代的杂芳基; X'表示包含酯化羧基或酰化羟基的取代基; 环A表示可被取代的苯环或可被取代的杂芳环; 环J'表示含有至多3个杂原子作为环构成成员的7或8元杂环，除R1，R2，R3和X'之外，还可以具有另外的取代基或取代基，C *表示 手性碳原子或其盐，其包括使式（I）的外消旋化合物或其盐或外消旋起始化合物合成式（I）化合物进行酶对映选择性水解以提供光学 其活性形式。