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    Gonadal function improving agents
    2.
    发明申请
    Gonadal function improving agents 有权
    性腺功能改善剂

    公开(公告)号：US20060287227A1

    公开(公告)日：2006-12-21

    申请号：US10547974

    申请日：2004-03-11

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K48/00 ,  A61K38/24

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

    Process for producing 1,3-dithiol-2-ylidene malonates
    3.
    发明授权
    Process for producing 1,3-dithiol-2-ylidene malonates 失效
    1,3-二硫醇-2-亚基丙二酸酯的制备方法

    公开(公告)号：US4327223A

    公开(公告)日：1982-04-27

    申请号：US252004

    申请日：1981-04-07

    申请人： Hisanori Matsui ,  Hiroshi Tanaka ,  Kunihiro Yabutani ,  Hitoshi Kurono

    发明人： Hisanori Matsui ,  Hiroshi Tanaka ,  Kunihiro Yabutani ,  Hitoshi Kurono

    IPC分类号： C07D339/06

    CPC分类号： C07D339/06

    摘要： A 1,3-dithiol-2-ylidene malonic acid dialkyl ester which was known as useful agricultural or horticultural fungicide and also as therapeutic agent for treating hepatic diseases can be prepared by a new process which comprises reacting a dialkyloxycarbonylketene dimercaptide with a trihalogenoethane in the presence of a base.

    摘要翻译： 已知为有用的农业或园艺杀真菌剂以及用作治疗肝脏疾病的治疗剂的1,3-二硫醇-2-亚基丙二酸二烷基酯可以通过新方法制备，该方法包括使二烷氧基羰基烯酮二硫醇与三卤代乙烷反应 存在基地

    GONADAL FUNCTION IMPROVING AGENTS
    4.
    发明申请
    GONADAL FUNCTION IMPROVING AGENTS 审中-公开
    全功能改善剂

    公开(公告)号：US20110052563A1

    公开(公告)日：2011-03-03

    申请号：US12710864

    申请日：2010-02-23

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K39/395 ,  A61K38/16 ,  A61K31/7088 ,  A61K31/711 ,  A61P15/08 ,  A61P15/00 ,  A61P5/00

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

    Methods of inhibiting secretion of follicle-stimulating hormone and testosterone
    7.
    发明授权
    Methods of inhibiting secretion of follicle-stimulating hormone and testosterone 有权
    抑制促卵泡激素和睾丸激素分泌的方法

    公开(公告)号：US07754220B2

    公开(公告)日：2010-07-13

    申请号：US10547974

    申请日：2004-03-11

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K38/16 ,  A61K38/17

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

    Process for producing 1,2,4-triazolin-5-one derivatives, and intermediates therefor
    9.
    发明授权
    Process for producing 1,2,4-triazolin-5-one derivatives, and intermediates therefor 失效
    制备1,2,4-三唑啉-5-酮衍生物的方法及其中间体

    公开(公告)号：US4845232A

    公开(公告)日：1989-07-04

    申请号：US923935

    申请日：1986-10-24

    申请人： Hisanori Matsui ,  Keiji Sutoh ,  Moriharu Yamamoto ,  Kazuhiro Takagi ,  Kunihiro Yabutani ,  Kuniaki Taninaka ,  Mitsuru Kajioka

    发明人： Hisanori Matsui ,  Keiji Sutoh ,  Moriharu Yamamoto ,  Kazuhiro Takagi ,  Kunihiro Yabutani ,  Kuniaki Taninaka ,  Mitsuru Kajioka

    IPC分类号： C07D249/12

    CPC分类号： C07D249/12

    摘要： A process for producing 1,2,4-triazolin-5-one derivatives represented by the general formula (I) ##STR1## wherein R is a haloalkyl group of 1 to 5 carbon atoms and R.sup.1 is a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, an alkyl group of 1 to 6 carbon atoms having halogen atom substituents, a cycloalkyl group of 3 to 6 carbon atoms, a cycloalkyl group of 3 to 6 carbon atoms having halogen atom substituents, a cyanoalkyl group of 2 to 4 carbon atoms, an alkenyl group of w to 6 carbon atoms, an alkynyl group of 2 to 6 carbon atoms, a lower alkoxyalkyl group of 2 to 6 carbon atoms, a lower alkylthioalkyl group of 2 to 8 carbon atoms, a lower alkylsufinylalkyl group of 2 to 6 carbon atoms, a lower alkylsufonylalkyl group of 2 to 6 carbon atoms, a lower alkoxyalkoxyalkyl group of 3 to 8 carbon atoms, a hydroxycarbonylalkyl group of 2 to 3 carbon atoms, a lower alkoxycarbonylalkyl group of 3 to 6 carbon atoms, a benzylgroup, a benzyl group having 1 to 2 substituents (selected from a halogen atom, a lower alkyl group of 1 to 3 carbon atoms, a lower alkoxy group of 1 to 3 carbon atoms, a nitro group, a lower alkoxycarbonyl group of 2 to 4 carbon atoms, a hydroxycarbonyl group and a phenoxy group), an alpha-methylbenzyl group or a phenethyl group.

    摘要翻译： 一种由通式（I）表示的1,2,4-三唑啉-5-酮衍生物的方法，其中R是1至5个碳原子的卤代烷基，R 1是氢原子， 具有1至6个碳原子的烷基，具有卤素原子取代基的1至6个碳原子的烷基，3至6个碳原子的环烷基，具有卤素原子取代基的3至6个碳原子的环烷基，氰基烷基 2至4个碳原子的链烯基，2至6个碳原子的炔基，2至6个碳原子的低级烷氧基烷基，2至8个碳原子的低级烷硫基烷基， 2至6个碳原子的低级烷基磺酰基烷基，2至6个碳原子的低级烷基磺酰基烷基，3至8个碳原子的低级烷氧基烷氧基烷基，2至3个碳原子的羟基羰基烷基，3至6个低级烷氧基羰基烷基 碳原子，苄基，具有1〜2个取代基的苄基（选自a 卤素原子，1〜3个碳原子的低级烷基，1〜3个碳原子的低级烷氧基，硝基，2〜4个碳原子的低级烷氧基羰基，羟基羰基和苯氧基）， α-甲基苄基或苯乙基。