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    Methods For Producing Heterologous Polypeptides In Mutants Of Trichoderma
    22.
    发明申请
    Methods For Producing Heterologous Polypeptides In Mutants Of Trichoderma 审中-公开

    公开(公告)号：US20180312849A1

    公开(公告)日：2018-11-01

    申请号：US16033618

    申请日：2018-07-12

    Applicant: Novozymes, Inc.

    Inventor： Sandra Merino ,  Judilee Quintos ,  Debbie Yaver

    IPC: C12N15/52 ,  C12N9/00 ,  C12P21/00 ,  C12P21/02 ,  C12N9/88

    CPC classification number: C12N15/52 ,  C12N9/88 ,  C12N9/93 ,  C12P21/00 ,  C12P21/02

    Abstract: The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more genes selected from the group consisting of a peptaibol synthetase gene, a paracelsin synthetase gene, a first terpene cyclase gene, a second terpene cyclase gene, and a third terpene cyclase gene, wherein one or more of the genes are modified rendering the mutant strain deficient in the production of one or more of the enzymes selected from the group consisting of a peptaibol synthetase, a paracelsin synthetase, a first terpene cyclase, a second terpene cyclase, and a third terpene cyclase compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.

    Polypeptides Having Xylanase Activity And Polynucleotides Thereof
    26.
    发明申请
    Polypeptides Having Xylanase Activity And Polynucleotides Thereof 审中-公开
    具有木聚糖酶活性的多肽及其多核苷酸

    公开(公告)号：US20150197737A1

    公开(公告)日：2015-07-16

    申请号：US14668599

    申请日：2015-03-25

    Applicant: Novozymes, Inc.

    Inventor： Debbie Yaver ,  Paul Harris ,  Suzanne Otani ,  Janine Lin ,  Hanshu Ding

    IPC: C12N9/24

    CPC classification number: C12N9/2482 ,  C12N9/248 ,  C12Y302/01008

    Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

    Abstract translation: 本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用多肽的方法。

    Promoter Variants For Expressing Genes In A Fungal Cell
    27.
    发明申请
    Promoter Variants For Expressing Genes In A Fungal Cell 审中-公开
    在真菌细胞中表达基因的启动子变体

    公开(公告)号：US20140099669A1

    公开(公告)日：2014-04-10

    申请号：US14097659

    申请日：2013-12-05

    Applicant: Novozymes, Inc.

    Inventor： Debbie Yaver ,  Peter Nham

    IPC: C12N15/113 ,  C12P21/00

    CPC classification number: C12N15/80 ,  C12N9/0044 ,  C12N9/20 ,  C12N9/58 ,  C12N9/93 ,  C12N15/113 ,  C12P1/02 ,  C12P21/00 ,  C12Y107/01003 ,  C12Y301/01003 ,  C12Y304/21004 ,  C12Y603/04002

    Abstract: The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances.

    Abstract translation: 本发明涉及生物体的制造方法，其特征在于，包括：（a）在有助于生物生物的培养基中培养真菌宿主细胞，其中所述真菌宿主细胞可操作地包含编码生物物质的第一核酸序列 连接到第二核酸序列，其包含选自SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6，SEQ ID NO： ：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：11和SEQ ID NO：12; 及其后果; 及其杂交和串联启动子; 和（b）从培养基中分离生物物质。 本发明还涉及分离的启动子变体和构建体，载体和真菌宿主细胞，其包含可操作地连接于编码生物物质的核酸序列的启动子变体。

    Methods for Improved C4-Dicarboxylic Acid Production in Filamentous Fungi
    28.
    发明申请
    Methods for Improved C4-Dicarboxylic Acid Production in Filamentous Fungi 审中-公开
    丝状真菌中C4-二羧酸改良方法

    公开(公告)号：US20130288321A1

    公开(公告)日：2013-10-31

    申请号：US13926421

    申请日：2013-06-25

    Applicant: Novozymes, Inc.

    Inventor： Sheryl Luttringer ,  Debbie Yaver

    IPC: C12P7/46

    CPC classification number: C12P7/46 ,  C07K14/38

    Abstract: The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides.

    Abstract translation: 本发明涉及生产C4-二羧酸如苹果酸的方法，其包括：（a）培养包含编码C4-二羧酸转运蛋白的多核苷酸的宿主细胞; 和（b）回收C4-二羧酸。 本发明还涉及增加C4-二羧酸产生的方法以及包含多核苷酸的宿主细胞。

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