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21.发明授权Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 有权取代的苯甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08796295B2
公开(公告)日：2014-08-05
申请号：US12885378
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A61K31/505 , A61K31/44 , C07D239/02 , C07D417/12
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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22.发明授权MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 失效MGLUR4变构增强剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08779157B2
公开(公告)日：2014-07-15
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： C07D233/00
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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![Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction](/abs-image/US/2014/02/25/US08658650B2/abs.jpg.150x150.jpg)
23.发明授权Substituted 1,1,3,1-tetraoxidobenzo[D][1,3,2]dithiazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的1,1,3,1-四氧化苯并[D] [1,3,2]二噻唑作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08658650B2
公开(公告)日：2014-02-25
申请号：US13146909
申请日：2010-01-28
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
IPC分类号： A61K31/41 , A61K31/4439 , A61K31/506 , A61K31/444 , C07D417/12 , C07D419/14 , C07D285/01
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物和使用该化合物的方法。
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24.发明授权Substituted heteroarylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 失效取代的杂芳基胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08569308B2
公开(公告)日：2013-10-29
申请号：US12885245
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates
IPC分类号： A01N37/30 , A61K31/205
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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25.发明申请ARYL AND HETEROARYL SULFONES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权ARYL和HETEROARYL SULFONES作为MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245185A1
公开(公告)日：2012-09-27
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , C07D417/04 , A61K31/427 , C07D213/81 , C12N5/02 , C07D307/68 , A61K31/341 , C07D239/28 , A61K31/505 , C07D401/04 , A61K31/4402
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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26.发明申请SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS 审中-公开作为MGLUR4电位的替代的杀伤甾烷酰胺和取代的吲哚磺酰胺公开(公告)号：US20120184556A1
公开(公告)日：2012-07-19
申请号：US13386651
申请日：2010-07-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： A61K31/53 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/427 , A61K31/506 , A61K31/422 , A61K31/454 , C07D235/18 , C07D401/04 , C07D409/04 , C07D403/04 , C07D417/04 , C07D413/04 , C07D405/04 , A61K31/404 , A61K31/437 , A61K31/5025 , A61K31/4985 , A61K31/519 , C07D471/04 , C07D209/08 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/04 , A61P25/08 , A61P35/00 , A61P3/00 , A61P29/00 , A61P25/28 , C12N5/071 , C07D235/08 , C07D401/12 , C07D405/10 , A61K31/4545 , C07D401/14 , A61K31/4184
CPC分类号： A61K31/415 , A61K31/404 , A61K45/06 , C07D235/06 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04 , A61K2300/00
摘要： Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
摘要翻译： 公开了取代的苯并咪唑磺酰胺和取代的吲唑磺酰胺作为mGluR4增效剂。
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![SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION](/abs-image/US/2011/12/29/US20110319429A1/abs.jpg.150x150.jpg)
27.发明申请SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 有权取代1,1,3,1-三羟基苯并[D] [1,3,2]二甲氧基硅烷作为MGLUR4不同位置电位，组合物和治疗神经功能障碍的方法公开(公告)号：US20110319429A1
公开(公告)日：2011-12-29
申请号：US13146909
申请日：2010-01-28
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Rocco D. Gogliotti , Darren W. Engers
IPC分类号： A61K31/41 , C07D417/12 , C07D419/14 , A61K31/4439 , A61K31/506 , A61K31/444 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/04 , A61P3/00 , A61P25/08 , A61P35/00 , A61P29/00 , A61P3/10 , A61P25/14 , C07D285/01
CPC分类号： C07D285/01 , C07D403/12 , C07D417/12 , C07D417/14
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物和使用该化合物的方法。
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28.发明授权Aryl and heteroaryl sulfones as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权芳基和杂芳基砜作为mGluR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08912336B2
公开(公告)日：2014-12-16
申请号：US13508535
申请日：2010-11-08
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Yiu-Yin Cheung
IPC分类号： C07D401/04 , C07D417/04 , C07D213/81 , C07D239/28 , C07D307/56
CPC分类号： C07D401/04 , C07D213/81 , C07D239/28 , C07D307/56 , C07D417/04
摘要： In one aspect, the invention relates to sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的砜化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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29.发明授权Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权取代的二氧代哌啶和二氧代吡咯烷作为MGLUR4变构增效剂，组合物和治疗神经功能障碍的方法公开(公告)号：US08759377B2
公开(公告)日：2014-06-24
申请号：US12952640
申请日：2010-11-23
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers
IPC分类号： A61K31/4439 , C07D401/12
摘要： In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及具有一般结构的化合物：其中变量在本文中定义，其可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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30.发明申请MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION 失效MGLUR4 ALLOSTERIC电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20120245153A1
公开(公告)日：2012-09-27
申请号：US13394309
申请日：2010-09-07
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Charles David Weaver , Colleen M. Niswender , Darren W. Engers , Patrick R. Gentry , Yiu-Yin Cheung , James M. Salovich , Rocco D. Gogliotti
IPC分类号： A61K31/542 , A61K31/4985 , A61K31/506 , A61K31/437 , A61K31/4439 , C07D513/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D401/12 , A61P25/18 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/16 , A61P25/28 , A61K31/5377
CPC分类号： C07D487/04 , C07D401/10 , C07D471/04 , C07D498/04 , C07D513/04
摘要： Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/阳性变构调节剂的化合物及其用途。
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