公开(公告)号：US20080095736A1

公开(公告)日：2008-04-24

申请号：US11985588

申请日：2007-11-16

Applicant: Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

Inventor： Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

IPC: A61K31/74 ,  A61P43/00

CPC classification number: A61K9/0024 ,  A61K31/74 ,  A61K47/34 ,  A61K47/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  C08G63/08 ,  C08G63/912

Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

Abstract translation: 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。