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    Biocompatible polymers and hydrogels and methods of use
    2.
    发明申请
    Biocompatible polymers and hydrogels and methods of use 有权
    生物相容性聚合物和水凝胶及其使用方法

    公开(公告)号：US20080095736A1

    公开(公告)日：2008-04-24

    申请号：US11985588

    申请日：2007-11-16

    申请人： Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

    发明人： Chandrashekhar Pathak ,  Amarpreet Sawhney ,  Peter Edelman

    IPC分类号： A61K31/74 ,  A61P43/00

    CPC分类号： A61K9/0024 ,  A61K31/74 ,  A61K47/34 ,  A61K47/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  C08G63/08 ,  C08G63/912

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。

    Methods for forming regional tissue adherent barriers and drug delivery systems
    6.
    发明申请
    Methods for forming regional tissue adherent barriers and drug delivery systems 审中-公开

    公开(公告)号：US20060177481A1

    公开(公告)日：2006-08-10

    申请号：US11375998

    申请日：2006-03-15

    申请人： Amarpreet Sawhney

    发明人： Amarpreet Sawhney

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0024 ,  A61K47/34 ,  A61L31/145 ,  A61L31/148 ,  Y10S514/944

    摘要： Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.

    Multifunctional organic polymers
    10.
    发明授权
    Multifunctional organic polymers 失效
    多功能有机聚合物

    公开(公告)号：US5462990A

    公开(公告)日：1995-10-31

    申请号：US132507

    申请日：1993-10-05

    申请人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    发明人： Jeffrey A. Hubbell ,  Donald Elbert ,  Jennifer L. Hill-West ,  Paul D. Drumheller ,  Sanghamitra Chowdhury ,  Amarpreet Sawhney

    IPC分类号： A61L27/00 ,  A61K9/50 ,  A61K47/48 ,  A61L31/06 ,  A61L33/00 ,  C08G63/91 ,  C08G73/00 ,  C08G81/00 ,  C08G81/02 ,  C08L77/00 ,  C08L79/00 ,  C08L101/00 ,  C09D187/00 ,  C08L1/00

    CPC分类号： C08G81/00 ,  A61K47/48238 ,  A61K47/48315 ,  A61K9/5031 ,  A61K9/5073 ,  A61L31/06

    摘要： Described herein is a multi-functional polymeric material for use in inhibiting adhesion and immune recognition between cells and cells, cells and tissues, and tissues and tissues. One component of the polymeric material adsorbs well to cells or tissue, and the other component of the polymeric material does not adsorb well to tissues. A water-soluble polymer that does not bear charge (polynonion) is used as the non-binding component, and a water soluble polymer that is positively charged at physiological pH (polycation) is used as the tissue binding component. When the bi-functional polymeric material contacts a tissue, the tissue-binding component binds and thus immobilizes the attached non-binding component, which will then extend generally away from the tissue surface and sterically block the attachment of other tissues. The method and compositions are useful in inhibiting formation of post-surgical adhesions, protecting damaged blood vessels from thrombosis and restenosis, and decreasing the extent of metastasis of attachment-dependent tumor cells.

    摘要翻译： 本文描述的是用于抑制细胞和细胞，细胞和组织以及组织和组织之间的粘附和免疫识别的多功能聚合物材料。 聚合物材料的一个组分很好地吸附到细胞或组织上，而聚合物材料的其它组分不能很好地吸附到组织上。 使用不带电荷的水溶性聚合物（多项式）作为非结合成分，使用在生理pH（聚阳离子）下带正电的水溶性聚合物作为组织结合成分。 当双官能聚合物材料接触组织时，组织结合组分结合并因此固定所连接的非结合组分，其然后将一般远离组织表面延伸，并空间阻断其它组织的附着。 该方法和组合物可用于抑制手术后粘连的形成，保护受损的血管免受血栓形成和再狭窄，并降低附着依赖性肿瘤细胞的转移程度。