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49 条记录 (耗时 0.033 秒)

    System and method for transdermal delivery
    23.
    发明申请
    System and method for transdermal delivery 审中-公开
    用于透皮给药的系统和方法

    公开(公告)号：US20060036209A1

    公开(公告)日：2006-02-16

    申请号：US10978806

    申请日：2004-11-01

    申请人： Janardhanan Subramony ,  Georg Widera ,  Joseph Phipps ,  Michel Cormier

    发明人： Janardhanan Subramony ,  Georg Widera ,  Joseph Phipps ,  Michel Cormier

    IPC分类号： A61N1/30

    CPC分类号： A61N1/303 ,  A61M37/0015 ,  A61M2037/0023 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/306 ,  A61N1/327

    摘要： A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.

    摘要翻译： 一种用于透皮递送生物活性剂的系统和方法，所述生物活性剂包括一个或多个具有角质层刺穿突起的电极和将电信号传递到电极以电穿孔细胞膜的电路。 优选地，该系统被配置为产生均匀的电场，并且更优选地，以产生球形或半对称电场。 本发明的方法包括施加第一电信号以促进试剂的透皮转运并施加第二电信号以促进试剂的细胞内运输。

    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
    24.
    发明申请
    Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition 有权
    透皮电运输装置包括抗微生物相容的储存器组合物

    公开(公告)号：US20050187511A1

    公开(公告)日：2005-08-25

    申请号：US11084628

    申请日：2005-03-18

    申请人： Wendy Young ,  Michel Cormier

    发明人： Wendy Young ,  Michel Cormier

    IPC分类号： A61B10/02 ,  A61N1/30

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。 水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。 丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。 还提供了一种制备透皮电转运药物递送装置的方法。

    Intravitreal injection device and system
    28.
    发明申请
    Intravitreal injection device and system 有权
    玻璃体内注射装置和系统

    公开(公告)号：US20100100054A1

    公开(公告)日：2010-04-22

    申请号：US12456439

    申请日：2009-06-16

    申请人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    发明人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    IPC分类号： A61M5/32

    CPC分类号： A61F9/0017 ,  A61M5/24 ,  A61M5/46 ,  A61M2005/2407 ,  A61M2005/2488

    摘要： An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

    摘要翻译： 一种玻璃体内注射系统，用于向眼睛的玻璃体腔内施用药物制剂，其包含（i）与适于在其中接受和容纳其药理学制剂的内部制剂室耦合或包含的注射构件（ii） ）具有与制剂室和第二注射端连通的第一端的针，以及（iii）用于将系统定位在眼睛上的引导针，并且将针的穿入深度限制到 眼。

    Stable Therapeutic Formulations
    29.
    发明申请
    Stable Therapeutic Formulations 有权
    稳定的治疗配方

    公开(公告)号：US20070184096A1

    公开(公告)日：2007-08-09

    申请号：US11617639

    申请日：2006-12-28

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    IPC分类号： A61K48/00 ,  A61K9/70 ,  A61K31/716

    CPC分类号： A61K9/0021 ,  A61K9/703 ,  A61K31/716 ,  A61K38/2242 ,  A61K38/29 ,  A61K48/00 ,  A61K2039/54 ,  A61M37/0015 ,  A61M2037/0023 ,  B65B7/02 ,  B65B31/00 ,  B65B51/10 ,  B65B55/00 ,  B65D81/20 ,  B65D81/266 ,  Y02A50/471 ,  Y02A50/478

    摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

    摘要翻译： 用于配制和递送具有增强的物理稳定性的生物活性剂制剂的组合物和方法，并且其中由氧和/或水的存在引起的劣化被最小化和/或控制，以产生稳定的制剂。 用于配制和递送本发明的生物活性剂的组合物和方法进一步促进它们掺入生物相容性涂层中，所述生物相容性涂层可用于涂覆角质层刺穿的微喷射体，或多个角质层刺穿的输送装置的微突出物 ，用于通过受试者的皮肤递送生物相容性涂层，从而提供递送生物活性剂的有效手段。

    Microprojection array immunization patch and method
    30.
    发明申请
    Microprojection array immunization patch and method 审中-公开
    微量阵列免疫贴片及方法

    公开(公告)号：US20060074377A1

    公开(公告)日：2006-04-06

    申请号：US11267563

    申请日：2005-11-04

    申请人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  Peter Daddona ,  Juanita Johnson ,  Wendy Young

    IPC分类号： A61B17/20 ,  A61M37/00

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0061 ,  Y02A50/401

    摘要： Skin patches (20) having a microprojection array (10), a reservoir (18) containing an antigenic agent and an immune response augmenting adjuvant, and methods of using same to vaccinate animals (e.g., humans) is disclosed. In a preferred embodiment, the microprojection arrays (10) are composed of a photoetched and micro-punched titanium foil (14). The microprojections (12) are coated with a liquid formulation containing a vaccine antigen and an adjuvant such as glucosaminyl muramyl dipeptide, dried, and applied to skin of the animal to be vaccinated using an impact applicator. The microprojections (12) create superficial pathways through the stratum corneum to facilitate permeation of antigenic agent and adjuvant. Antigen dose and depth of penetration can be controlled. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy, and convenience of use.

    摘要翻译： 公开了具有微喷射阵列（10）的皮肤贴片（20），含有抗原剂和免疫应答增强佐剂的储液器（18）及其使用方法来接种动物（例如人）。 在优选实施例中，微喷射阵列（10）由光刻和微冲压钛箔（14）组成。 微注射物（12）用含有疫苗抗原和佐剂（例如葡糖胺基胞壁酰二肽）的液体制剂包衣，干燥，并使用冲击施加器施用于待接种疫苗的皮肤。 微突出物（12）产生通过角质层的浅表通路以促进抗原剂和佐剂的渗透。 可以控制抗原剂量和穿透深度。 该技术广泛适用于各种各样的治疗性疫苗，以提高功效和使用方便。