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13 条记录 (耗时 0.022 秒)

    Pretreatment method and system for enhancing transdermal drug delivery
    2.
    发明申请
    Pretreatment method and system for enhancing transdermal drug delivery 审中-公开
    增强透皮药物输送的预处理方法和系统

    公开(公告)号：US20050106226A1

    公开(公告)日：2005-05-19

    申请号：US10970901

    申请日：2004-10-21

    申请人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    发明人： Michel Cormier ,  WeiQi Lin ,  Juanita Johnson ,  Kofi Nyam

    IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61M20060101 ,  A61M37/00

    CPC分类号： A61K9/7084 ,  A61K9/0021 ,  A61K9/703 ,  A61M37/0015 ,  A61M2037/0023

    摘要： A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient's skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient's skin after the pretreatment patch is applied to and removed from the patient's skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.

    摘要翻译： 用于递送生物活性剂通过患者皮肤的药物递送系统包括（i）适于放置在患者皮肤上的预处理贴剂，所述预处理贴片具有背衬膜和微突出物阵列，所述微突出物阵列粘附到 所述背衬膜，所述微突出物阵列包括适于刺穿所述患者角质层的多个微突出物，所述预处理贴片包括在将所述预处理贴片施加到患者皮肤并从患者皮肤移除之后残留在患者皮肤上的皮肤模板，以及 （ii）具有顶部和底部表面的凝胶贴片，所述凝胶贴片包括含有水凝胶制剂的储存器，所述凝胶贴片具有在约0.5-30cm 2范围内的皮肤接触面积。

    Drug delivery and method having coated microprojections incorporating vasoconstrictors
    4.
    发明申请
    Drug delivery and method having coated microprojections incorporating vasoconstrictors 审中-公开
    具有包含血管收缩剂的包被微粒体的药物递送和方法

    公开(公告)号：US20080226687A1

    公开(公告)日：2008-09-18

    申请号：US12154373

    申请日：2008-05-21

    申请人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    发明人： Michel Cormier ,  James Matriano ,  WeiQi Lin ,  Wendy Young

    IPC分类号： A61K9/00 ,  A61K39/00 ,  A61K31/135 ,  A61K38/38

    CPC分类号： A61K9/0021 ,  A61K45/06

    摘要： A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.

    摘要翻译： 提供了用于经皮透皮递送生物活性剂的装置和方法。 使用已知的涂覆技术将含有生物活性剂和血管收缩剂的包衣制剂施用于皮肤刺穿元件，然后干燥。 将该装置应用于活的动物的皮肤，导致微突出物刺穿角质层并向动物输送有效剂量的生物活性剂和血管收缩剂。

    Ultrasound assisted transdermal vaccine delivery method and system
    6.
    发明申请
    Ultrasound assisted transdermal vaccine delivery method and system 审中-公开
    超声辅助透皮疫苗递送方法和系统

    公开(公告)号：US20050112135A1

    公开(公告)日：2005-05-26

    申请号：US10971338

    申请日：2004-10-21

    申请人： Michel Cormier ,  WeiQi Lin ,  Georg Widera

    发明人： Michel Cormier ,  WeiQi Lin ,  Georg Widera

    IPC分类号： A61B17/20 ,  A61K39/00 ,  A61K39/12 ,  A61K39/29 ,  A61M37/00 ,  A61M31/00

    CPC分类号： A61B17/205 ,  A61K9/0009 ,  A61K9/0021 ,  A61K39/00 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61M37/0092 ,  C12N2730/10134

    摘要： An apparatus and method for transdermally delivering a vaccine comprising a delivery system having (i) a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers and (ii) an ultrasonic device. In one embodiment, the vaccine is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a vaccine-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the vaccine is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于经皮递送疫苗的装置和方法，包括递送系统，该递送系统具有（i）包括多个微突出物（或阵列）的微突出物构件（或系统），所述微突出物构件（或系统）适于穿透角质层进入下面的表皮层， 或表皮和真皮层，和（ii）超声波装置。 在一个实施方案中，疫苗被包含在施加到微喷射构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有含疫苗的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，疫苗包含在包衣和水凝胶制剂中。