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公开(公告)号：US20050123565A1
公开(公告)日：2005-06-09
申请号：US10971877
申请日：2004-10-21
CPC分类号： A61B17/205 , A61B2017/00765 , A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： A system and method for transdermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.
摘要翻译： 一种用于向患者透皮递送疫苗的系统和方法，包括具有供体电极的离子电渗递送装置，对电极和用于向电极提供离子电渗能量的电路，以及具有多个角质层的非电活性微突出物构件 从其延伸的微喷射。 疫苗可以包含在设置在供体电极附近的药剂容器中的水凝胶制剂中，该生物相容性涂层设置在微喷射体上或两者中。
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公开(公告)号：US20060036209A1
公开(公告)日：2006-02-16
申请号：US10978806
申请日：2004-11-01
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61M37/0015 , A61M2037/0023 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306 , A61N1/327
摘要： A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.
摘要翻译： 一种用于透皮递送生物活性剂的系统和方法，所述生物活性剂包括一个或多个具有角质层刺穿突起的电极和将电信号传递到电极以电穿孔细胞膜的电路。 优选地，该系统被配置为产生均匀的电场，并且更优选地，以产生球形或半对称电场。 本发明的方法包括施加第一电信号以促进试剂的透皮转运并施加第二电信号以促进试剂的细胞内运输。
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3.发明申请Methods for preparing polymeric buffer formulations for electrotransport applications 审中-公开制备用于电转运应用的聚合物缓冲剂配方的方法公开(公告)号：US20050129655A1
公开(公告)日：2005-06-16
申请号：US10994004
申请日：2004-11-19
CPC分类号： A61N1/0448 , A61K9/0095 , A61N1/0412
摘要： The present invention provides methods for preparing compositions for use in electrotransport delivery systems that comprise providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a first ion exchange material; separating the first ion exchange material from the pH-adjusted drug solution; adding the pH-adjusted drug solution to a reservoir of an electrotransport delivery system; and contacting the pH-adjusted drug solution with a second ion exchange material.
摘要翻译： 本发明提供了用于制备用于电转运递送系统的组合物的方法，其包括提供包含药物离子和相关抗衡离子的药物溶液; 通过使药液与第一离子交换材料接触来调节药液的pH; 将第一离子交换材料与pH调节药液分离; 将pH调节的药物溶液加入到电转运递送系统的储存器中; 并将pH调节的药物溶液与第二离子交换材料接触。
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公开(公告)号：US20070060861A1
公开(公告)日：2007-03-15
申请号：US11513761
申请日：2006-08-30
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448
摘要： A cathode for an electrotransport drug delivery system for the delivery of anionic drugs. The cathode has a composite structure that contains an electroactive species that upon reduction does not generate any gas or an anion that competes with the anionic drug during electrotransport.
摘要翻译： 用于递送阴离子药物的电转运药物递送系统的阴极。 阴极具有包含电活性物质的复合结构，其在还原时不产生在电输运期间与阴离子药物竞争的任何气体或阴离子。
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公开(公告)号：US20070149916A1
公开(公告)日：2007-06-28
申请号：US11613327
申请日：2006-12-20
IPC分类号： A61N1/30 , A61K38/16 , A61K31/573 , A61K31/473 , A61K31/445 , A61K31/24
CPC分类号： A61N1/30 , A61N1/0448
摘要： The present invention provides methods and devices for the electrotransport delivery of beneficial agents that utilize polymer electrolyte matrices as drug reservoirs. In certain aspects of the invention, the beneficial agents are hydrolytically unstable, and methods are provided for enhancing the stability of the hydrolytically unstable beneficial agents during long-term storage of devices for the electrotransport delivery of the hydrolytically unstable beneficial agents and during electrotransport delivery of the hydrolytically unstable beneficial agents.
摘要翻译： 本发明提供了利用聚合物电解质基质作为药物储库的有益药物的电转运递送方法和装置。 在本发明的某些方面，有益试剂是水解不稳定的，并且提供了用于增强水解不稳定有益试剂在长期储存用于电转移递送水解不稳定有益剂的装置和在电输送期间的稳定性的方法 水解不稳定的有益剂。
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公开(公告)号：US20050273047A1
公开(公告)日：2005-12-08
申请号：US11144005
申请日：2005-06-01
IPC分类号： A61K9/00 , A61K9/70 , A61K31/155 , A61K31/455 , A61N1/30 , A61N1/32 , A61P7/02
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/7023 , A61K31/155 , A61K31/455 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： A device for transdermally delivering an anticoagulant agent by electrotransport. Preferably, the anticoagulant comprises a benzamidine or a naphthamidine derivative. A particularly preferred benzamidine derivative is a 2-[3-[4-(4-piperidinyloxy)anilino]-1-propenyl]benzamidine derivative. The devices are configured to maintain a plasma concentration of 20-80 ng/mL or providing a flux in the range of approximately 20-40 mg/day. Suitable current densities include 0.050 and 0.10 mA/cm2. Methods of the invention include delivering the anticoagulants to precisely maintain the desired plasma concentrations. The invention also comprises treating thromboembolic disease and inhibiting Factor Xa.
摘要翻译： 用于通过电转运透皮递送抗凝血剂的装置。 优选地，抗凝血剂包含苯甲脒或萘啶脒衍生物。 特别优选的苯甲脒衍生物是2- [3- [4-（4-哌啶基氧基）苯胺基] -1-丙烯基]苯甲脒衍生物。 这些装置被配置为维持20-80ng / mL的血浆浓度或提供约20-40mg /天范围内的通量。 合适的电流密度包括0.050和0.10mA / cm 2。 本发明的方法包括递送抗凝剂以精确地保持所需血浆浓度。 本发明还包括治疗血栓栓塞性疾病和抑制因子Xa。
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7.发明申请Peptidically buffered formulations for electrotransport applications and methods of making 审中-公开用于电转运应用的肽缓冲制剂和制备方法公开(公告)号：US20050142531A1
公开(公告)日：2005-06-30
申请号：US10993649
申请日：2004-11-19
申请人： David Rauser , Rama Padmanabhan , Joseph Phipps , Michel Cormier
发明人： David Rauser , Rama Padmanabhan , Joseph Phipps , Michel Cormier
CPC分类号： A61N1/0448 , A61K9/0095 , A61N1/0412
摘要： Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.
摘要翻译： 制备用于电转运系统的组合物的方法。 该方法包括提供包含药物离子和相关联的抗衡离子的药物溶液; 首先通过使药液与离子交换材料接触来调节药液的pH值; 将离子交换材料与pH调节药液分离; 并用缓冲液缓冲pH调节的药物溶液。 优选使用肽缓冲剂。 该方法导致组合物适用于电转运递送系统。
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8.发明申请Electrotransport delivery device having improved safety and reduced abuse potential 失效电传输装置具有改进的安全性和降低的滥用潜力公开(公告)号：US20060116662A1
公开(公告)日：2006-06-01
申请号：US11334001
申请日：2006-01-18
申请人： Larry McNichols , John Badzinski , William Reining , Gary Lattin , Ronald Haak , Joseph Phipps
发明人： Larry McNichols , John Badzinski , William Reining , Gary Lattin , Ronald Haak , Joseph Phipps
IPC分类号： A61K9/22
CPC分类号： A61N1/0436 , A61N1/0412 , A61N1/0428 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： An electrotransport device for delivering one or more therapeutic agents through the skin includes electrodes for contacting the skin, at least one electrode containing the agent, a power source for generating electrical current (IL) for delivering the agent, a current generating and controlling means and a disabling means for permanently and irreversibly disabling the current. The disabling means may include a timer means, a counter means, or a body parameter sensor and limit comparator to effect permanent disabling. The disabling means may be a permanent transition to a disabled logic state, a permanent discharge of a power supply source, or a permanent diversion of electrotransport current from the electrodes, or a combination of the above. The permanent disabling means may include a circuit connection means having a frangible conducting member which permanently fractures and causes an irreversible open circuit in the connection to the electrodes upon removing a disposable/single use electrode assembly from a reusable portion of an electrotransport device.
摘要翻译： 用于通过皮肤递送一种或多种治疗剂的电输送装置包括用于接触皮肤的电极，至少一个含有药剂的电极，用于产生电流（I L L L）的用于输送药剂的电源 ，电流产生和控制装置和用于永久地和不可逆地禁用电流的禁用装置。 禁用装置可以包括定时器装置，计数器装置或身体参数传感器和限制比较器以实现永久禁用。 禁用装置可以是永久性转换到禁用的逻辑状态，电源的永久放电，或者电极的电输送电流的永久转移，或上述的组合。 永久性禁用装置可以包括电路连接装置，该电路连接装置具有永久性断裂的易碎导电构件，并且在从电输送装置的可重复使用部分移除一次性/单次使用电极组件时，在与电极的连接中引起不可逆的开路。
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9.发明申请公开(公告)号：US20050131337A1
公开(公告)日：2005-06-16
申请号：US11051174
申请日：2005-02-03
申请人： Joseph Phipps , Mary Southam , Keith Bernstein , Henk Noorduin
发明人： Joseph Phipps , Mary Southam , Keith Bernstein , Henk Noorduin
IPC分类号： A61K9/00 , A61K31/4468 , A61K31/4535 , A61N1/30 , A61P25/04
CPC分类号： A61N1/0436 , A61N1/0448
摘要： The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (eg, fentanyl hydrochloride) dispersed in a hydrogel formulation for use in an electrotransport device (10). In accordance with one aspect of the invention, the concentration of fentanyl/sufentanil in the donor reservoir (26) solution is above a predetermined minimum concentration, whereby the transdermal electrotransport flux of fentanyl/sufentanil is maintained independent of the concentration of fentanyl/sufentanil in solution. In accordance with a second aspect of the present invention, the donor reservoir (26) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) contains a predetermined “excess” loading of fentanyl/sufentanil halide to prevent silver ion migration with attendant skin discoloration. In accordance with a third aspect of the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (eg, adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
摘要翻译： 本发明提供了一种用于镇痛药物，即芬太尼和舒芬太尼的改进的电转运药物递送系统。 芬太尼/舒芬太尼作为分散在用于电转运装置（10）的水凝胶制剂中的水溶性盐（例如盐酸芬太尼）提供。 根据本发明的一个方面，供体储存器（26）溶液中芬太尼/舒芬太尼的浓度高于预定的最小浓度，由此芬太尼/舒芬太尼的透皮电转运通量与芬太尼/舒芬太尼的浓度无关 解。 根据本发明的第二方面，电运输输送装置（10）的供体储存器（26）由银组成，供体储存器（26）含有预定的“过量”负荷的芬太尼/舒芬太尼卤化物以防止 银离子迁移伴随皮肤变色。 根据本发明的第三方面，提供透皮电转运量的芬太尼/舒芬太尼，其足以在与主要外科手术相关的中度至重度疼痛的（例如成人）人类患者中诱发镇痛。
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公开(公告)号：US20050010192A1
公开(公告)日：2005-01-13
申请号：US10875032
申请日：2004-06-23
申请人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Joseph Phipps
发明人： Ying Sun , Jeffrey Wu , Jue-Chen Liu , Joseph Phipps
CPC分类号： A61N1/0492 , A61K8/19 , A61K8/20 , A61K8/27 , A61K8/365 , A61K8/368 , A61K2800/28 , A61K2800/83 , A61N1/0428 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/205 , A61N1/30 , A61N1/303 , A61N1/325 , A61Q19/008 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： The present invention features a method of treating pores on the skin by applying to skin in need of such treatment a device including a housing having a skin contacting surface, a first conductive electrode, a second conductive electrode, and a carrier; wherein the first conductive electrode is in electric communication with the second conductive electrode, wherein the first conductive electrode is in ionic communication with the carrier, wherein the carrier is in communication with the skin contacting surface, and wherein the skin contacting surface is placed in contact with the skin.
摘要翻译： 本发明的特征在于一种通过向需要这种治疗的皮肤施加皮肤处理孔的方法，该装置包括具有皮肤接触表面的壳体，第一导电电极，第二导电电极和载体; 其中所述第一导电电极与所述第二导电电极电连通，其中所述第一导电电极与所述载体离子连通，其中所述载体与所述皮肤接触表面连通，并且其中所述皮肤接触表面接触 与皮肤。
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