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30 条记录 (耗时 0.044 秒)

    Methods and Processes for Attaching Compounds to Matrices
    22.
    发明申请
    Methods and Processes for Attaching Compounds to Matrices 有权
    将化合物连接到基质的方法和方法

    公开(公告)号：US20100096251A1

    公开(公告)日：2010-04-22

    申请号：US12641002

    申请日：2009-12-17

    申请人： Seetharamaiyer Padmanabhan ,  Radhakrishnan P. Iyer

    发明人： Seetharamaiyer Padmanabhan ,  Radhakrishnan P. Iyer

    IPC分类号： C07C67/00

    CPC分类号： B05D3/06 ,  C07K1/1077 ,  C07K1/22 ,  G01N33/54353 ,  Y02P20/582

    摘要： The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.

    摘要翻译： 本发明描述了通过使用微波技术将化学部分附着到基质上的非常快速和有效的方法。 本发明的方法可以以各种方式应用于制备用于各种应用的不同类型的基质，包括但不限于各种固体支持物的功能化，以及粉末，珠粒，片状物的形式的基质， 和其他合适的表面，用于包括但不限于寡核苷酸合成，肽合成，环境清洁（去除有毒物质），免疫测定，亲和层析，组合化学，微阵列，蛋白质组学和医学诊断等应用。

    Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
    24.
    发明授权
    Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages 失效
    用于合成含有二硫代磷酸核苷间键的寡核苷酸的试剂和方法

    公开(公告)号：US6117992A

    公开(公告)日：2000-09-12

    申请号：US920087

    申请日：1997-08-26

    申请人： Radhakrishnan P. Iyer

    发明人： Radhakrishnan P. Iyer

    IPC分类号： C07H1/02 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00

    CPC分类号： C07H21/00 ,  Y02P20/55

    摘要： The invention provides new methods for synthesizing oligonucleotides containing at least one, and preferably all phosphorodithioate internucleoside linkages with less than 5% phosphoromonothioate contamination. This level of purity in the synthesis of phosphorodithoates has previously been very difficult to achieve with all existing methods. The invention further provides phosphorothioamidite nucleoside synthons comprising a sulfur protecting group that is stable under normal oligonucleotide synthesis conditions.

    摘要翻译： 本发明提供了用于合成寡核苷酸的新方法，所述寡核苷酸含有少于5％的硫代磷酸酯污染物的至少一种，优选全部是二硫代磷酸酯核苷间键。 以前，使用所有现有方法难以实现磷酸二酯合成中的这种纯度。 本发明还提供了包含在正常寡核苷酸合成条件下稳定的硫保护基团的硫代亚甲酰胺核苷合成体。

    DESIGN OF OLIGONUCLEOTIDE ANALOGS AS THERAPEUTIC AGENTS
    26.
    发明申请
    DESIGN OF OLIGONUCLEOTIDE ANALOGS AS THERAPEUTIC AGENTS 审中-公开
    作为治疗剂的寡核苷酸类似物的设计

    公开(公告)号：US20150329864A1

    公开(公告)日：2015-11-19

    申请号：US14691019

    申请日：2015-04-20

    申请人： Radhakrishnan P. Iyer ,  John Edward Coughlin

    发明人： Radhakrishnan P. Iyer ,  John Edward Coughlin

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1131 ,  A61K31/7084 ,  A61K31/713 ,  C07H21/04 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2320/30

    摘要： The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention.It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.

    摘要翻译： 本发明涉及可用于各种治疗应用的短寡核苷酸及其类似物（例如，二核苷酸和三核苷酸化合物）的设计。 据信本发明的化合物可以用作抗病毒剂，抗癌剂等。 在某些实施方案中，本发明的化合物可以调节免疫刺激途径和非TLR途径。 本发明还涉及用于治疗应用的设计修饰的寡核苷酸，通过从经修饰的寡核苷酸排除具有脱靶效应的核苷酸区段。 另一方面，本发明提供包含一种或多种本发明化合物的药物组合物。 据信本文所述的化合物和组合物具有针对各种疾病（包括病毒性疾病，自身免疫性疾病（例如过敏，哮喘和炎性疾病））和癌症的治疗效用。

    METHODS AND PROCESSES FOR ATTACHING COMPOUNDS TO MATRICES
    27.
    发明申请
    METHODS AND PROCESSES FOR ATTACHING COMPOUNDS TO MATRICES 审中-公开
    将化合物连接到基质的方法和方法

    公开(公告)号：US20130078390A1

    公开(公告)日：2013-03-28

    申请号：US13627170

    申请日：2012-09-26

    申请人： Seetharamaiyer Padmanabhan ,  Radhakrishnan P. Iyer

    发明人： Seetharamaiyer Padmanabhan ,  Radhakrishnan P. Iyer

    IPC分类号： B05D3/06

    CPC分类号： B05D3/06 ,  C07K1/1077 ,  C07K1/22 ,  G01N33/54353 ,  Y02P20/582

    摘要： The present invention describes extremely rapid and efficient methods for the attachment of chemical moieties to matrices by the use of microwave technology. The methods of the invention can be applied in a variety of ways for the preparation of different types of matrices for a variety of applications including but not limited to the functionalization of various solid supports, and matrices in the form of powder, beads, sheets, and other suitable surfaces for use in applications including but not limited to oligonucleotide synthesis, peptide synthesis, environmental clean up (removal of toxic materials), immunoassays, affinity chromatography, combinatorial chemistry, microarrays, proteomics and medical diagnostics.

    摘要翻译： 本发明描述了通过使用微波技术将化学部分附着到基质上的非常快速和有效的方法。 本发明的方法可以以各种方式应用于制备用于各种应用的不同类型的基质，包括但不限于各种固体支持物的功能化，以及粉末，珠粒，片状物的形式的基质， 和其他合适的表面，用于包括但不限于寡核苷酸合成，肽合成，环境清洁（去除有毒物质），免疫测定，亲和层析，组合化学，微阵列，蛋白质组学和医学诊断等应用。

    COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    29.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS 有权
    用于治疗病毒感染的组合物和方法

    公开(公告)号：US20110207690A1

    公开(公告)日：2011-08-25

    申请号：US12897389

    申请日：2010-10-04

    申请人： Radhakrishnan P. Iyer ,  Seetharamaiyer Padmanabhan

    发明人： Radhakrishnan P. Iyer ,  Seetharamaiyer Padmanabhan

    IPC分类号： A61K31/7084 ,  A61P31/14

    CPC分类号： A61K31/7076 ,  A61K31/70 ,  A61K31/7056 ,  A61K31/7084 ,  C07H19/04 ,  C07H19/052 ,  Y02A50/385 ,  Y02A50/393

    摘要： The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such as HBV and/or HIV. In one embodiment, the present invention provides compositions having the formula (I) and their use in treating viral infections: or a pharmaceutically acceptable salt, ester, stereoisomer, tautomers, solvate, prodrug, or combination thereof.

    摘要翻译： 本发明提供用于治疗易感病毒感染，特别是丙型肝炎病毒（HCV）感染以及HCV与其它病毒如HBV和/或HIV的共感染的组合物方法。 在一个实施方案中，本发明提供具有式（I）的组合物及其在治疗病毒感染中的用途：或其药学上可接受的盐，酯，立体异构体，互变异构体，溶剂合物，前药或其组合。