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公开(公告)号：US20140141417A1
公开(公告)日：2014-05-22
申请号：US13683756
申请日：2012-11-21
申请人： Graham P. Lidgard
发明人： Graham P. Lidgard
IPC分类号： G06F19/10
CPC分类号： G06F19/20 , C12Q1/6851 , C12Q1/686 , C12Q2537/143 , C12Q2537/164 , C12Q2561/109 , G06F19/18 , G06F19/24
摘要： Provided herein is technology relating to evaluating the state of nucleic acids and particularly, but not exclusively, to methods for measuring variations between DNAs, including differences in methylation and mutation.
摘要翻译： 本文提供了与评估核酸状态有关的技术，特别但并非排他地涉及用于测量DNA之间变化的方法，包括甲基化和突变的差异。
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公开(公告)号：US6162608A
公开(公告)日：2000-12-19
申请号：US357898
申请日：1999-07-21
IPC分类号： C07K14/47 , C07K16/18 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/68 , G01N33/531 , G01N33/567
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
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公开(公告)号：US5840503A
公开(公告)日：1998-11-24
申请号：US444821
申请日：1995-05-18
IPC分类号： C07K14/47 , C07K16/18 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/68 , G01N33/567 , C12Q1/00
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for evaluating the efficacy of a therapy associated with cell death in a patient undergoing such a therapy. The method involves providing at least two body fluid samples drawn from the patient, wherein a second sample is drawn from the patient after a first sample, and measuring the quantity per unit volume of a body-fluid soluble interior nuclear matrix protein in each of the samples. By comparing the quantity per unit volume of the body fluid-soluble interior nuclear matrix protein in the first sample with the quantity per unit volume of the body fluid-soluble interior nuclear matrix protein in the second sample, it is possible to determine whether there has been an increase or decrease of cell death in the patient during therapy.
摘要翻译： 公开了一种用于评估在接受这种治疗的患者中与细胞死亡相关的疗法的功效的方法。 该方法包括提供从患者抽取的至少两个体液样品，其中在第一样品之后从患者抽出第二样品，并测量每个体液溶液内核核基质蛋白的每单位体积的量 样品。 通过比较第一样品中体液可溶性内部核基质蛋白的单位体积量与第二样品中体液可溶性内部核基质蛋白的单位体积量，可以确定是否存在 是治疗期间患者细胞死亡的增加或减少。
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24.发明授权Binding proteins to malignant cell type markers of the interior nuclear matrix 失效将蛋白结合到内部核基质的恶性细胞型标记物中
公开(公告)号：US5780596A
公开(公告)日：1998-07-14
申请号：US467781
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , A61K39/395
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US5686562A
公开(公告)日：1997-11-11
申请号：US466390
申请日：1995-06-06
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , A61K38/16 , C07K5/00 , C07K7/00
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
摘要翻译： 公开了用作两种内部核基质蛋白的遗传序列及其编码的氨基酸序列，其用作恶性细胞类型的标志物。 本发明提供了蛋白质的一级和二级结构分析以及其重组生产的方法，以及在临床测定和癌症治疗中使用这些标记物的组合物和方法。
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公开(公告)号：US06410247B1
公开(公告)日：2002-06-25
申请号：US09687188
申请日：2000-10-12
IPC分类号： G01N3353
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
摘要翻译： 公开了一种用于检测和定量体液和细胞外介质中的可溶性核基质蛋白的方法。 该方法可用于监测细胞和组织的活力，用于评估疾病进展或其治疗，以及评估未知化合物的细胞毒性。 还公开了诱导从细胞释放可溶形式的核基质蛋白质的方法。
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公开(公告)号：US5965376A
公开(公告)日：1999-10-12
申请号：US443630
申请日：1995-05-18
IPC分类号： C07K14/47 , C07K16/18 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/68 , G01N33/567 , G01N33/531
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed are methods for determining the degree of cell death in a tissue by detecting and quantitating soluble interior nuclear matrix proteins and protein fragments in body fluids and extracellular media. The methods are useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of interior nuclear matrix proteins and protein fragment in soluble form from cells.
摘要翻译： 公开了通过检测和定量体液和细胞外介质中的可溶性内部核基质蛋白质和蛋白质片段来确定组织中细胞死亡程度的方法。 该方法可用于监测细胞和组织的活力，用于评估疾病进展或其治疗，以及评估未知化合物的细胞毒性。 还公开了诱导从细胞释放可溶形式的内部核基质蛋白质和蛋白质片段的方法。
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公开(公告)号：US06740494B2
公开(公告)日：2004-05-25
申请号：US10151717
申请日：2002-05-20
IPC分类号： G01N3353
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
摘要翻译： 公开了一种用于检测和定量体液和细胞外介质中可溶性核基质蛋白的方法。 该方法可用于监测细胞和组织的活力，用于评估疾病进展或其治疗，以及评估未知化合物的细胞毒性。 还公开了诱导从细胞释放可溶形式的核基质蛋白质的方法。
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公开(公告)号：US5989826A
公开(公告)日：1999-11-23
申请号：US456620
申请日：1995-06-01
IPC分类号： C07K14/47 , C07K16/18 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/68 , G01N33/531 , G01N33/567
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed are methods for determining the degree of cell death in a tissue by detecting and quantitating soluble interior nuclear matrix proteins and protein fragments in body fluids and extracellular media. The methods are is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of interior nuclear matrix proteins and protein fragments in soluble form from cells.
摘要翻译： 公开了通过检测和定量体液和细胞外介质中的可溶性内部核基质蛋白质和蛋白质片段来确定组织中细胞死亡程度的方法。 该方法对于监测细胞和组织的活力，用于评估疾病进展或其治疗以及评估未知化合物的细胞毒性是有用的。 还公开了用于诱导从细胞释放可溶形式的内部核基质蛋白质和蛋白质片段的方法。
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公开(公告)号：US5783403A
公开(公告)日：1998-07-21
申请号：US195487
申请日：1994-02-14
申请人： Gary Toukatly , Graham P. Lidgard
发明人： Gary Toukatly , Graham P. Lidgard
IPC分类号： G01N33/574 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/19 , C12P21/08
摘要： Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.
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