公开(公告)号：US08876758B2

公开(公告)日：2014-11-04

申请号：US13089884

申请日：2011-04-19

申请人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

发明人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

IPC分类号： A61M5/30 ,  A61M31/00 ,  A61K9/00 ,  A61M5/20

CPC分类号： A61M5/30 ,  A61K9/0021 ,  A61K9/0024 ,  A61M5/2053 ,  A61M37/0069

摘要： Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

摘要翻译： 描述了粘稠的制剂，并且将在高驱动压力下从无针运送中获益。 通过皮下注射器常规递送这些粘稠制剂是不方便和痛苦的。 制剂包括在约20℃下具有约5cS或更高的粘度的那些，其可以在约0.1秒±0.02秒内通过无针注射器施用0.5ml或更多。

公开(公告)号：US20110196336A1

公开(公告)日：2011-08-11

申请号：US13089884

申请日：2011-04-19

申请人： Brooks M. BOYD ,  Sujata Mudumba ,  Stephen J. Farr

发明人： Brooks M. BOYD ,  Sujata Mudumba ,  Stephen J. Farr

IPC分类号： A61M5/30

CPC分类号： A61M5/30 ,  A61K9/0021 ,  A61K9/0024 ,  A61M5/2053 ,  A61M37/0069

摘要： Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

摘要翻译： 描述了粘稠的制剂，并且将在高驱动压力下从无针运送中受益。 通过皮下注射器常规递送这些粘稠制剂是不方便和痛苦的。 制剂包括在约20℃下具有约5cS或更高的粘度的那些，其可以在约0.1秒±0.02秒内通过无针注射器施用0.5ml或更多。

公开(公告)号：US20110118189A1

公开(公告)日：2011-05-19

申请号：US12937355

申请日：2009-04-24

申请人： Stephen J. Farr ,  John Turanin ,  Roger Hawley ,  Jeffrey A. Schuster

发明人： Stephen J. Farr ,  John Turanin ,  Roger Hawley ,  Jeffrey A. Schuster

IPC分类号： A61K38/16 ,  A61P25/06 ,  A61P1/08 ,  A61K31/404 ,  A61K31/403 ,  A61K31/454 ,  A61K31/48 ,  A61K31/616 ,  A61K31/485 ,  A61K31/5415 ,  A61K31/56 ,  A61P25/24 ,  A61K31/439

CPC分类号： A61M5/30 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/0024 ,  A61K9/16 ,  A61K31/4045 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/44 ,  A61K31/454 ,  A61K45/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36

摘要： Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting, which include sustained release formulations, and combination products. Also included are treatments for multiple symptoms of migraine, especially headache and nausea and vomiting. Systems that are self contained, portable, prefilled, and simple to self administer at the onset of a migraine attack are disclosed, and preferably include a needle-free injector and a high viscosity formulation, to eliminate such issues as fear of self administration with needles, and needle stick and cross contamination.

摘要翻译： 描述了用于治疗偏头痛和相关病症如丛集性头痛的不满足的医疗需求的系统和方法。 包括快速发作和长效的治疗，包括持续释放制剂和组合产品。 还包括治疗偏头痛的多种症状，特别是头痛，恶心和呕吐。 公开了在偏头痛发作开始时是自包含的，便携式的，预填充的和易于自我施用的系统，并且优选地包括无针注射器和高粘度制剂，以消除诸如担心自身给药的问题 ，针刺和交叉污染。

公开(公告)号：US5292499A

公开(公告)日：1994-03-08

申请号：US828195

申请日：1992-01-30

申请人： Richard M. Evans ,  Stephen J. Farr

发明人： Richard M. Evans ,  Stephen J. Farr

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K38/28 ,  A61K9/12

CPC分类号： A61K9/008 ,  A61K38/28 ,  A61K9/1075 ,  Y10S514/937

摘要： The present invention provides a method for the production of medicinal aerosol compositions which are made up of a homogenous solution of aerosol propellants, a surfactant and a pharmaceutically active compound, where the process comprises purifying the surfactant, removing the water from the surfactant, and dispersing the surfactant in an aerosol propellant with a hydrophilic pharmaceutical composition and a controlled amount of water. The present invention also provides medicinal aerosol compositions produced by this method which are a homogenous solution of the pharmaceutically active compound contained in reverse micelles made up of the surfactant; and methods of using the medicinal aerosols to provide an effective amount of a therapeutic agent.

摘要翻译： 本发明提供了一种药物气溶胶组合物的制备方法，其由气溶胶推进剂，表面活性剂和药物活性化合物的均匀溶液组成，其中该方法包括净化表面活性剂，从表面活性剂中除去水，并分散 具有亲水药物组合物和受控量的水的气溶胶推进剂中的表面活性剂。 本发明还提供了通过该方法制备的药物气溶胶组合物，其是由表面活性剂组成的反胶束中所含的药物活性化合物的均匀溶液; 以及使用药用气溶胶提供有效量的治疗剂的方法。

公开(公告)号：US09186461B2

公开(公告)日：2015-11-17

申请号：US13562596

申请日：2012-07-31

申请人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

发明人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

IPC分类号： A61M5/30 ,  A61K9/00 ,  A61M5/20

CPC分类号： A61M5/30 ,  A61K9/0021 ,  A61K9/0024 ,  A61M5/2053 ,  A61M37/0069

摘要： Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second ±0.02 seconds.

摘要翻译： 描述了粘稠的制剂，并且将在高驱动压力下从无针运送中获益。 通过皮下注射器常规递送这些粘稠制剂是不方便和痛苦的。 制剂包括在约20℃下具有约5cS或更高的粘度的那些，其可以在约0.1秒±0.02秒内通过无针注射器施用0.5ml或更多。

公开(公告)号：US08066661B2

公开(公告)日：2011-11-29

申请号：US12032044

申请日：2008-02-15

申请人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

发明人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

IPC分类号： A61M5/30

CPC分类号： A61M5/30 ,  A61K9/0021 ,  A61K9/0024 ,  A61M5/2053 ,  A61M37/0069

摘要： Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

摘要翻译： 描述了粘稠的制剂，并且将在高驱动压力下从无针运送中获益。 通过皮下注射器常规递送这些粘稠制剂是不方便和痛苦的。 制剂包括在约20℃下具有约5cS或更高的粘度的那些，其可以在约0.1秒±0.02秒内通过无针注射器施用0.5ml或更多。

公开(公告)号：US20120296270A1

公开(公告)日：2012-11-22

申请号：US13562596

申请日：2012-07-31

申请人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

发明人： Brooks M. Boyd ,  Sujata Mudumba ,  Stephen J. Farr

IPC分类号： A61M5/30

CPC分类号： A61M5/30 ,  A61K9/0021 ,  A61K9/0024 ,  A61M5/2053 ,  A61M37/0069

摘要： Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.

摘要翻译： 描述了粘稠的制剂，并且将在高驱动压力下从无针运送中获益。 通过皮下注射器常规递送这些粘稠制剂是不方便和痛苦的。 制剂包括在约20℃下具有约5cS或更高的粘度的那些，其可以在约0.1秒±0.02秒内通过无针注射器施用0.5ml或更多。

公开(公告)号：US20090241950A1

公开(公告)日：2009-10-01

申请号：US12464627

申请日：2009-05-12

申请人： Igor Gonda ,  Reid M. Rubasamen ,  Stephen J. Farr

发明人： Igor Gonda ,  Reid M. Rubasamen ,  Stephen J. Farr

IPC分类号： A61M15/00 ,  A61M16/10

CPC分类号： A61K9/007 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0445 ,  A61K9/0073 ,  A61K9/0075 ,  A61K38/28 ,  A61M11/001 ,  A61M15/00 ,  A61M15/0031 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0065 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M16/142 ,  A61M2016/0021 ,  A61M2016/0036 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2205/50 ,  A61M2205/8206

摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient=s breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release.

摘要翻译： 可以通过递送雾化的单体胰岛素制剂来减少或消除通过注射递送胰岛素的需要。 相对于常规胰岛素，给药的重复性更特别是血液浓度对时间曲线的重复性得到改善。 血液浓度对时间曲线基本上不受患者在分娩时呼吸机动的特定方面的影响。 此外，通过使用单体胰岛素来增加血糖降低的速度。 胰岛素的颗粒，特别是递送到肺组织表面的单体胰岛素将被吸收到循环系统中。 单体胰岛素可以是干粉，但是优选地是从手持式独立装置输送到患者的液体制剂，其自动释放雾化的制剂爆发。 该装置包括传感器，其优选是电子的，其测量吸气流量和体积，该测量可用于控制药物释放点。

公开(公告)号：US06874507B2

公开(公告)日：2005-04-05

申请号：US10913103

申请日：2004-08-06

申请人： Stephen J. Farr

发明人： Stephen J. Farr

IPC分类号： A24F47/00 ,  A61M15/00 ,  A61M15/06 ,  A61M16/10 ,  A16M16/00

CPC分类号： A24F47/002 ,  A61M15/009 ,  A61M15/06 ,  A61M16/10 ,  A61M2209/06

摘要： A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

公开(公告)号：US06799576B2

公开(公告)日：2004-10-05

申请号：US10147390

申请日：2002-05-15

申请人： Stephen J. Farr

发明人： Stephen J. Farr

IPC分类号： A61M1600

CPC分类号： A24F47/002 ,  A61M15/009 ,  A61M15/06 ,  A61M16/10 ,  A61M2209/06

摘要： A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

摘要翻译： 公开了一种系统，其使得患者随着时间逐渐递送尼古丁的量逐渐减少，从而允许患者逐渐脱离对尼古丁和戒烟的依赖。 该系统包括用于使制剂和制剂容器雾化的装置。 制剂由药学上可接受的载体中的尼古丁组成。 优选地，制造多个容器，其中不同容器或不同容器组中的尼古丁浓度降低。 患者首先使用浓度最高的容器，并逐渐转向使用浓度较低和较低浓度的尼古丁的容器，直到患者对尼古丁的依赖被消除。