Patent search ap:("Richard R. Tidwell" OR "James Edwin Hall") AND inv:"Richard R. Tidwell" Page 3

21.

发明授权
Methods of treating retroviral infection and compounds useful therefor 失效
Title translation: 治疗逆转录病毒感染的方法及其有用的化合物

公开(公告)号：US5935982A

公开(公告)日：1999-08-10

申请号：US808321

申请日：1997-02-28

Applicant: Christine C. Dykstra , David Boykin , Richard R. Tidwell

Inventor： Christine C. Dykstra , David Boykin , Richard R. Tidwell

IPC: A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61P31/18 , A61P37/04 , C07D235/20 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , A61K31/415

CPC classification number: C07D403/14 , C07D235/20 , C07D405/14 , C07D413/14

Abstract: The present invention provides methods for treating retroviral infection and methods of treating HIV infection. The methods of the present invention include administering compounds of the general Formula I: ##STR1## wherein L, R.sub.1, R.sub.2, R.sub.3, R.sub.4 are defined herein.

Abstract translation: 本发明提供了治疗逆转录病毒感染的方法和治疗HIV感染的方法。本发明的方法包括施用通式I的化合物：其中L，R 1，R 2，R 3，R 4在本文中定义。

22.

发明授权
Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor 失效
Title translation: 使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法，以及可用于其的试剂盒

公开(公告)号：US5723288A

公开(公告)日：1998-03-03

申请号：US238766

申请日：1994-05-06

Applicant: Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar

Inventor： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson , Jaroslaw Spychala , Bijan P. Das , Arvind Kumar

IPC: G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58

CPC classification number: G01N33/52 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , Y10S435/808 , Y10S435/81

Abstract: Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis�4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl! furan; 2,5-bis{�4-(N-isopropyl) amidino! phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.

Abstract translation: 公开了一种荧光检测核酸的方法。该方法包括使双酸性芳基呋喃化合物如2,5-双[4-（4,5,6,7-四氢-1H-1,3-二氮杂-2-基）苯基 ]呋喃 2,5-双{[4-（N-异丙基）脒基]苯基}呋喃; 和其生理上可接受的盐，并且以一定的频率使核酸暴露以诱导化合物的荧光。还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。

23.

发明授权
Methods of treating pneumocystis carinii pneumonia 失效
Title translation: 治疗卡氏肺囊虫肺炎的方法

公开(公告)号：US5686456A

公开(公告)日：1997-11-11

申请号：US564879

申请日：1995-11-28

Applicant: David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar

Inventor： David W. Boykin , Christine C. Dykstra , Richard R. Tidwell , James E. Hall , W. David Wilson , Arvind Kumar

IPC: G01N33/50 , A61K31/505 , A61K31/506 , C07D239/26 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58

CPC classification number: C07D239/26 , A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52

Abstract: The present invention provides methods for treating Pneumocystis carinii pneumonia in a subject in need of such treatment. The methods comprise administering to a subject in need thereof, a pyrimidine of Formula I. ##STR1## wherein the variables are as defined in the specification.

Abstract translation: 本发明提供了在需要这种治疗的个体中治疗卡氏肺囊虫肺炎的方法。所述方法包括向有需要的受试者施用式I的嘧啶。其中变量如说明书中所定义。

24.

发明授权
Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans 失效
Title translation: 使用双阳离子芳基呋喃荧光检测核酸和细胞骨架元件的方法

公开(公告)号：US5667975A

公开(公告)日：1997-09-16

申请号：US485381

申请日：1995-06-07

Applicant: Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson

Inventor： Christine C. Dykstra , Richard R. Tidwell , David W. Boykin , W. David Wilson

IPC: G01N33/50 , A61K31/505 , A61K31/506 , C07D307/52 , C07D307/54 , C07D307/58 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/01 , C12Q1/68 , G01N21/78 , G01N33/52 , G01N33/58

CPC classification number: A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52 , Y10S435/81

Abstract: Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.

Abstract translation: 公开了一种荧光检测核酸的方法。所述方法包括使所述核酸与双阳离子芳基呋喃接触，并将所述核酸以一定频率曝光以诱导所述化合物的荧光。还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。

25.

发明授权
Methods of combating Pneumocystis carinii pneumonia and compounds useful therefor 失效
Title translation: 抵抗卡氏肺囊虫肺炎的方法及其有用的化合物

公开(公告)号：US5578631A

公开(公告)日：1996-11-26

申请号：US427597

申请日：1995-04-24

Applicant: Richard R. Tidwell , Christine C. Dykstra , James E. Hall

Inventor： Richard R. Tidwell , Christine C. Dykstra , James E. Hall

IPC: C07D235/14 , A61K31/415 , A61K31/4184 , A61P11/00 , A61P29/00 , A61P33/02 , A61P43/00 , C07D403/14 , A61K31/55 , A61K31/505

CPC classification number: C07D403/14 , A61K31/415

Abstract: Disclosed is a method of combating Pneumocystis carinii Pneumonia in a subject in need of such treatment. The method comprises administering to to the subject an effective Pneumocystis carinii-combating amount of a bis-benzimidazole compound such as bis[5-(2-imidazolyl)-2-benzimidazolyl]methane, 1,4-bis[5-2-imidazolyl)-2-benzimidazolyl]butane, or a pharmaceutically acceptable salt thereof. Pharmaceutical formulations for carrying out the method and novel compounds are also disclosed, along with methods of combating Giardia lamblia.

Abstract translation: 公开了一种在需要这种治疗的受试者中对抗卡氏肺囊虫肺炎的方法。该方法包括向受试者施用有效的卡氏肺囊虫抗性量的双苯并咪唑化合物，例如双[5-（2-咪唑基）-2-苯并咪唑基]甲烷，1,4-双[5-2-咪唑基）-2-苯并咪唑基]丁烷或其药学上可接受的盐。还公开了用于实施该方法和新化合物的药物制剂，以及与贾第鞭毛虫抗性的方法。

26.

发明授权
Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles 失效
Title translation: 阳离子3,5-二苯基异恶唑的合成和抗原虫活性

公开(公告)号：US07951827B2

公开(公告)日：2011-05-31

申请号：US11415982

申请日：2006-05-02

Applicant: Richard R. Tidwell , Svetlana M. Bakunova , Stanislav Bakunov , Donald A. Patrick

Inventor： Richard R. Tidwell , Svetlana M. Bakunova , Stanislav Bakunov , Donald A. Patrick

IPC: A61K31/42 , C07D261/06 , C07D413/02

CPC classification number: C07D261/08 , C07D413/10 , C07D413/14

Abstract: Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

Abstract translation: 描述了新型的阳离子3,5-二苯基异恶唑化合物。提供了这些新化合物的合成路线。几种化合物显示体外活性与布鲁斯氏锥虫和恶性疟原虫相当，与呋喃丹相当。大多数新型化合物对VERO细胞的毒性相对于呋脒更少。

27.

发明授权
Synthesis and antimicrobial activity of novel dicationic “reversed amidines” 有权
Title translation: 新型双阳离子“反脒”的合成与抗菌活性

公开(公告)号：US07745456B2

公开(公告)日：2010-06-29

申请号：US11825786

申请日：2007-07-09

Applicant: David W. Boykin , Richard R. Tidwell , W. David Wilson , John R. Perfect , Chad F. Stephens

Inventor： David W. Boykin , Richard R. Tidwell , W. David Wilson , John R. Perfect , Chad F. Stephens

IPC: A61K31/435 , A61K43/08 , A61K31/40 , A61K31/38 , A61K31/47 , C07D405/12 , C07D295/04 , C07D333/38 , C07D307/34 , C07D307/02

CPC classification number: C07D307/10 , C07D307/14 , C07D307/52 , C07D333/20 , C07D405/12 , C07D405/14 , C07D409/12

Abstract: The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.

Abstract translation: 本发明涉及通式的新的2,5-双{[烷基（或芳基）亚氨基]氨基苯基}呋喃和噻吩，其中R 1，R 2，R 3和R 4各自独立地选自H，烷基烷氧基，卤化物和卤代烷基; R5是H，烷基或芳基; R6是H，烷基，芳基或NR7R8，其中R7和R8各自独立地选自H，烷基和芳基; 并且X是O，S或NR 9，其中R 9是H或烷基，以及这些化合物的用途。

28.

发明申请
Cationic substituted benzofurans as antimicrobial agents 审中-公开
Title translation: 阳离子取代的苯并呋喃作为抗微生物剂

公开(公告)号：US20080221191A1

公开(公告)日：2008-09-11

申请号：US11982229

申请日：2007-10-31

Applicant: Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov

Inventor： Richard R. Tidwell , Karl Werbovetz , Scott Gary Franzblau , Svetlana Bakunova , Stanislav Bakunov

IPC: A61K31/4178 , C07D307/78 , A61K31/343 , C07D407/02 , A61P31/04

CPC classification number: C07D307/80

Abstract: A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.

Abstract translation: 一种通过向受试者施用有效量的阳离子取代的苯并呋喃化合物来治疗有需要的受试者的结核分枝杆菌感染的方法。治疗微生物感染的方法，包括原生动物病原体的感染，例如杜氏利什曼原虫，罗非鱼锥虫，克氏锥虫和恶性疟原虫，以及真菌病原体，例如白色念珠菌，烟曲霉和新型隐球酵母，需要的受试者其通过向受试者施用有效量的阳离子取代的苯并呋喃化合物。合成新型阳离子取代苯并呋喃化合物和新化合物本身的方法。