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1.发明授权公开(公告)号：US06737440B2
公开(公告)日：2004-05-18
申请号：US10008535
申请日：2001-11-06
IPC分类号： A61K3127
CPC分类号： C07D307/10 , C07D307/14 , C07D307/52 , C07D333/20 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
摘要翻译： 本发明涉及一般形式的新的2,5-双{[烷基（或芳基）亚氨基]氨基苯基}呋喃和噻吩，其中R 1，R 2，R 3和R 4各自独立地选自H，烷基， 烷氧基，卤化物和烷基卤基团; R5是H，烷基或芳基; R6是H，烷基，芳基或NR7R8，其中R7和R8各自独立地选自H，烷基和芳基; 并且X是O，S或NR 9，其中R 9是H或烷基，以及这些化合物的用途。
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2.发明授权公开(公告)号：US07241795B2
公开(公告)日：2007-07-10
申请号：US10791425
申请日：2004-03-02
IPC分类号： A61K31/40 , A61K31/38 , C07D207/04 , C07D333/38 , C07D307/34
CPC分类号： C07D307/10 , C07D307/14 , C07D307/52 , C07D333/20 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino]aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
摘要翻译： 本发明涉及通式的新的2,5-双{[烷基（或芳基）亚氨基]氨基苯基}呋喃和噻吩，其中R 1，R 2， R 3和R 4各自独立地选自H，烷基，烷氧基，卤化物和烷基卤化物基团; R 5是H，烷基或芳基; R 6是H，烷基，芳基或NR 7 R 8，其中R 7和R 7， 各自独立地选自H，烷基和芳基; 并且X是O，S或NR 9，其中R 9是H或烷基，以及这些化合物的用途。
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3.发明授权公开(公告)号：US07745456B2
公开(公告)日：2010-06-29
申请号：US11825786
申请日：2007-07-09
IPC分类号： A61K31/435 , A61K43/08 , A61K31/40 , A61K31/38 , A61K31/47 , C07D405/12 , C07D295/04 , C07D333/38 , C07D307/34 , C07D307/02
CPC分类号： C07D307/10 , C07D307/14 , C07D307/52 , C07D333/20 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, or NR7R8, in which R7 and R8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR9, in which R9 is H or alkyl, and to the use of such compounds.
摘要翻译： 本发明涉及通式的新的2,5-双{[烷基（或芳基）亚氨基]氨基苯基}呋喃和噻吩，其中R 1，R 2，R 3和R 4各自独立地选自H，烷基 烷氧基，卤化物和卤代烷基; R5是H，烷基或芳基; R6是H，烷基，芳基或NR7R8，其中R7和R8各自独立地选自H，烷基和芳基; 并且X是O，S或NR 9，其中R 9是H或烷基，以及这些化合物的用途。
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公开(公告)号：US06326395B1
公开(公告)日：2001-12-04
申请号：US09396836
申请日：1999-09-15
IPC分类号： A61K3134
CPC分类号： A61K31/4184 , A61K31/00 , A61K31/341
摘要： Methods of treating fungal infections comprise administering a therapeutically effective amount of a compound described by Formulas [(I)-(VI)]. Examples of fungal infections include Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Fusarium solani, and combinations thereof.
摘要翻译： 治疗真菌感染的方法包括施用治疗有效量的式[（I） - （VI）]所述的化合物。 真菌感染的实例包括白色念珠菌，新型隐球酵母，烟曲霉，茄病镰刀菌及其组合。
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公开(公告)号：US20120077767A1
公开(公告)日：2012-03-29
申请号：US13322237
申请日：2010-05-26
IPC分类号： A61K31/7048 , C40B30/00 , C12Q1/68 , A61K31/4196 , A61P31/00 , A61K31/137 , A61K31/505 , A61K31/343 , A61P31/10 , C12Q1/04 , A61K31/496
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/56961 , G01N2333/40 , G01N2800/60
摘要： Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in Table 2A in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. In another aspect, subjects identified as being infected with fungal infection are treated with anti-fungals.
摘要翻译： 用于鉴定真菌感染的方法，用于鉴定真菌感染的基因组和蛋白质标记物的测定法以及用于诊断真菌感染的方法。 一方面，通过蛋白质组学测定鉴定真菌感染的方法涉及测量外周血细胞样品中表2A所列蛋白质的蛋白质水平，并将确定的蛋白质水平与标准蛋白质水平进行比较。 在另一方面，鉴定为感染真菌感染的受试者用抗真菌剂治疗。
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