公开(公告)号：US11125695B2

公开(公告)日：2021-09-21

申请号：US16111646

申请日：2018-08-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Herbert Andres ,  Michaela Windfuhr ,  Oliver Larbolette ,  Stefan Quint

IPC: G01N21/76 ,  G01N21/66 ,  G01N33/543 ,  C07F15/00 ,  G01N27/30

Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

公开(公告)号：US20210063363A1

公开(公告)日：2021-03-04

申请号：US16996225

申请日：2020-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marc Kaminski ,  Stefan Quint ,  Benjamin Tiemann

IPC: G01N30/88 ,  G06F16/28 ,  G01N30/20

Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.

公开(公告)号：US20180348140A1

公开(公告)日：2018-12-06

申请号：US16044897

申请日：2018-07-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stefan Quint ,  Klaus Bauer-Espindola

IPC: G01N21/66 ,  G01N35/00 ,  G01N35/10 ,  G01N27/416 ,  G01N27/327

CPC classification number: C12Q1/00 ,  G01N33/5438 ,  G01N33/582

Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.