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公开(公告)号：US11959914B2
公开(公告)日：2024-04-16
申请号：US16652698
申请日：2019-01-29
Inventor： Tatsuki Takakura , Kenta Imai , Takaaki Hagiwara , Yoshihiro Yamashita , Taku Sakazume , Beatus Ofenloch-Haehnle , Michaela Windfuhr , Ursula Pauselius-Fuchs , Rita Haerteis
IPC: G01N33/543 , G01N35/02
CPC classification number: G01N33/543 , G01N35/02
Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.
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公开(公告)号：US11740254B2
公开(公告)日：2023-08-29
申请号：US16646622
申请日：2018-11-29
Inventor： Yuichiro Ota , Takaaki Hagiwara , Yoshihiro Yamashita , Koshin Hamasaki , Michaela Windfuhr , Heike Guggemos , Johannes Stoeckel , Guenter Ziegler , Michael Kuehnl
IPC: G01N35/10
CPC classification number: G01N35/1011 , G01N35/1016 , G01N2035/1025
Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.
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Patent Agency Ranking
公开(公告)号：US11125695B2
公开(公告)日：2021-09-21
申请号：US16111646
申请日：2018-08-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Herbert Andres , Michaela Windfuhr , Oliver Larbolette , Stefan Quint
IPC: G01N21/76 , G01N21/66 , G01N33/543 , C07F15/00 , G01N27/30
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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4.发明授权公开(公告)号：US09341575B2
公开(公告)日：2016-05-17
申请号：US13844778
申请日：2013-03-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andreas Finke , Bernhard Hauptmann , Johannes Stoeckel , Michaela Windfuhr
CPC classification number: G01N21/76 , B01L3/502715 , B01L3/502761 , G01N21/66
Abstract: The application provides methods for the detection of an analyte in a sample by electrochemiluminescence using certain reagent compositions. Reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the reagent compositions are disclosed. In particular, the application relates to the use of novel combinations of compounds, which can be used in said measurements to provide improved ECL assay performance.
Abstract translation: 该应用提供了使用某些试剂组合物通过电化学发光检测样品中的分析物的方法。 公开了试剂组合物，用于测量电化学发光的试剂盒（ECL）和使用该试剂组合物的电化学发光检测方法。 特别地，本申请涉及化合物的新组合的使用，其可用于所述测量以提供改进的ECL测定性能。
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公开(公告)号：US11517636B2
公开(公告)日：2022-12-06
申请号：US16640971
申请日：2018-09-10
Inventor： Hisashi Yabutani , Takeshi Ishida , Yoshihiro Yamashita , Taku Sakazume , Michaela Windfuhr , Bernhard Hauptmann , Andreas Finke
Abstract: An analyzer that has a simple configuration, that is inexpensive, that can improve safety, and that can inhibit proliferation of microorganisms using ultraviolet light is realized. A first electric power switch, a second electric power switch, and a third electric power switch are connected in series between an ultraviolet LED that irradiates an interior of a shared reagent storage container with ultraviolet light and a power supply that supplies electric power to the ultraviolet LED. The first electric power switch, the second electric power switch, and the third electric power switch are configured with two contact points and a connection section that connects and disconnects the two contact points. The first electric power switch is opened when a reagent storage door is opened, and the second electric power switch is opened in response to an action of extracting an ultraviolet irradiation section from a shared reagent storage container. The third electric power switch is opened when an amount of the reagent within the shared reagent storage container is equal to or smaller than a constant value. When one of the first electric power switch, the second electric power switch, and the third electric power switch is opened, supply of the electric power to the ultraviolet LED is intercepted.
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公开(公告)号：US11293934B2
公开(公告)日：2022-04-05
申请号：US16307787
申请日：2017-04-24
Inventor： Takeshi Ishida , Sakuichiro Adachi , Yoshihiro Yamashita , Shunichirou Nobuki , Hisashi Yabutani , Isao Yamazaki , Michaela Windfuhr , Bernhard Hauptmann , Simon Kuester
Abstract: An automatic analyzer is equipped with a sterilization mechanism removably attached to an opening of a container that holds a reagent and having an ultraviolet light generation section that radiates ultraviolet light; a suction nozzle removably attached, together with the sterilization mechanism, to the opening of the container; an analysis section adding the reagent drawn in by suction from the container via the suction nozzle to the reagent, and executing an analysis operation; and a control section exercising variable control over an irradiation light intensity of the ultraviolet light generated by the ultraviolet light generation section.
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公开(公告)号：US20180364175A1
公开(公告)日：2018-12-20
申请号：US16111646
申请日：2018-08-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans-Peter Josel , Herbert Andres , Michaela Windfuhr , Oliver Larbolette , Stefan Quint
Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
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