公开(公告)号：US06763607B2

公开(公告)日：2004-07-20

申请号：US10353746

申请日：2003-01-28

Applicant: Ronald A. Beyerinck ,  Heather L. M. Deibele ,  Dan E. Dobry ,  Roderick J. Ray ,  Dana M. Settell ,  Ken R. Spence

Inventor： Ronald A. Beyerinck ,  Heather L. M. Deibele ,  Dan E. Dobry ,  Roderick J. Ray ,  Dana M. Settell ,  Ken R. Spence

IPC: F26B312

CPC classification number: A61K9/1682 ,  A61J3/02 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/404 ,  A61K31/47 ,  B01J2/04

Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

公开(公告)号：US07887844B2

公开(公告)日：2011-02-15

申请号：US11004168

申请日：2004-12-03

Applicant: Leah E. Appel ,  Roderick J. Ray ,  David K. Lyon ,  James B. West ,  Scott B. McCray ,  Marshall D. Crew ,  Dwayne T. Friesen ,  Scott M. Herbig ,  Julian B. Lo

Inventor： Leah E. Appel ,  Roderick J. Ray ,  David K. Lyon ,  James B. West ,  Scott B. McCray ,  Marshall D. Crew ,  Dwayne T. Friesen ,  Scott M. Herbig ,  Julian B. Lo

IPC: A61K9/14 ,  A61K9/16

CPC classification number: A61K31/7032 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1694 ,  A61K31/4422

Abstract: A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.

Abstract translation: 用于药物的控制释放的多颗粒包括结晶药物，具有至少一个至少16个碳原子的烷基化物取代基的甘油酯和泊洛沙姆，其中至少70重量％的多颗粒中的药物是结晶的。

公开(公告)号：US20090142404A1

公开(公告)日：2009-06-04

申请号：US11747468

申请日：2005-08-18

Applicant: Leah E. Appel ,  Walter C. Babcock ,  Dwayne T. Friesen ,  Roderick J. Ray ,  Daniel T. Smithey ,  Sheri L. Shamblin ,  Ravi M. Shanker

Inventor： Leah E. Appel ,  Walter C. Babcock ,  Dwayne T. Friesen ,  Roderick J. Ray ,  Daniel T. Smithey ,  Sheri L. Shamblin ,  Ravi M. Shanker

IPC: A61K9/14 ,  A61K31/501

CPC classification number: A61K9/1682 ,  A61K9/0004 ,  A61K9/1629 ,  A61K9/1652 ,  A61K9/205 ,  A61K9/2846 ,  A61K31/496 ,  A61K31/505

Abstract: A dosage form comprises a low-solubility drug, and a precipitation-inhibiting polymer. The drug is in a solubility-improved form and in the form of particles at least partially coated with the precipitation-inhibiting polymer. Exemplified low-solubility drugs are ziprasidone and sildenafil. Exemplified precipitation-inhibiting polymer is HPMCAS.

Abstract translation: 剂型包含低溶解度药物和沉淀抑制聚合物。 该药物具有溶解度改善的形式，并且至少部分地涂有沉淀抑制聚合物的颗粒形式。 示例性低溶解度药物是齐拉西酮和西地那非。 示例性的沉淀抑制聚合物是HPMCAS。

公开(公告)号：US06986844B2

公开(公告)日：2006-01-17

申请号：US10607722

申请日：2003-06-27

Applicant: Robert P. Barss ,  Dwayne T. Friesen ,  Scott B. McCray ,  Kendall R. Pearson ,  Roderick J. Ray ,  Delores R. Sidwell ,  James B. West

Inventor： Robert P. Barss ,  Dwayne T. Friesen ,  Scott B. McCray ,  Kendall R. Pearson ,  Roderick J. Ray ,  Delores R. Sidwell ,  James B. West

IPC: B01D63/02 ,  B01D71/52

CPC classification number: B01D67/0093 ,  B01D67/0006 ,  B01D67/0011 ,  B01D69/08 ,  B01D69/12 ,  B01D69/125 ,  B01D71/56 ,  B01D71/62 ,  B01D2323/08 ,  B01D2323/30 ,  B65D85/812 ,  B65D2205/02

Abstract: Solvent-resistant polybenzimidazole membranes, methods of making them and crosslinking them and composite membranes and hollow fiber membrane modules from them are disclosed.

Abstract translation: 公开了耐溶剂聚苯并咪唑膜，制备它们并交联它们的方法以及复合膜和中空纤维膜组件。

公开(公告)号：US5041227A

公开(公告)日：1991-08-20

申请号：US595241

申请日：1990-10-09

Applicant: Paul van Eikeren ,  Daniel J. Brose ,  Roderick J. Ray

Inventor： Paul van Eikeren ,  Daniel J. Brose ,  Roderick J. Ray

IPC: A23L2/74 ,  B01D11/04 ,  B01D61/00 ,  B01D61/02 ,  B01D61/14 ,  B01D61/24 ,  B01D61/36 ,  B01D61/38 ,  B01D61/58 ,  C12M1/12 ,  C12P41/00

CPC classification number: B01D61/025 ,  A23L2/74 ,  B01D11/0415 ,  B01D61/027 ,  B01D61/145 ,  B01D61/243 ,  B01D61/246 ,  B01D61/362 ,  B01D61/364 ,  B01D61/38 ,  B01D61/58 ,  C12P41/004 ,  C12P41/007

Abstract: An improvement to processes for the selective extractation of organic solutes from organic solvents by water-based extractants is disclosed, the improvement comprising coupling various membrane separation processes with the organic extraction process, the membrane separation process being utilized to continuously recycle the water-based extractant and at the same time selectively remove or concentrate organic solute from the water-based extractant.

Abstract translation: 公开了通过水性萃取剂从有机溶剂中选择性萃取有机溶质的方法的改进，其改进包括将各种膜分离方法与有机萃取方法结合，膜分离方法用于连续再循环水基萃取剂 并且同时选择性地从水基萃取剂中除去或浓缩有机溶质。