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21.发明授权Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof 有权制备含有4-和5-咪唑基环的细胞因子抑制化合物的方法及其中间体公开(公告)号：US07858804B2
公开(公告)日：2010-12-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the intermediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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22.发明申请Process for Making Cytokine Inhibiting Compounds Containing 4- and 5-Imidazolyl Rings and the Intermediates Thereof 有权制备含有4-和5-咪唑环的细胞因子抑制化合物及其中间体的方法公开(公告)号：US20090137815A1
公开(公告)日：2009-05-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07F7/02 , C07D403/04 , C07D233/54
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the inter-mediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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![Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides](/abs-image/US/2008/12/30/US07470795B2/abs.jpg.150x150.jpg)
23.发明授权Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides 有权6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酸酰胺的合成公开(公告)号：US07470795B2
公开(公告)日：2008-12-30
申请号：US11188377
申请日：2005-07-25
申请人： Xiao-jun Wang , Thomas Wirth , Thomas Nicola , Li Zhang , Rogelio Perez Frutos , Yibo Xu , Dhileepkumar Krishnamurthy , Laurence John Nummy , Richard J. Varsolona , Chris Hugh Senanayake , Jutta Kroeber , Diana Reeves
发明人： Xiao-jun Wang , Thomas Wirth , Thomas Nicola , Li Zhang , Rogelio Perez Frutos , Yibo Xu , Dhileepkumar Krishnamurthy , Laurence John Nummy , Richard J. Varsolona , Chris Hugh Senanayake , Jutta Kroeber , Diana Reeves
IPC分类号： C07D235/00
CPC分类号： C07D487/04 , C07C275/24 , C07D239/06
摘要： Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
摘要翻译： 公开了制备式I化合物的多步法：其中R 1至R 3如本文所定义。 式I的化合物抑制人细胞间粘附分子与白血球素结合。 结果，这些化合物可用于治疗炎性和免疫细胞介导的疾病。
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公开(公告)号：US20080214870A1
公开(公告)日：2008-09-04
申请号：US12032727
申请日：2008-02-18
IPC分类号： C07C251/00
CPC分类号： C07D291/04 , C07B2200/07 , C07C209/52 , C07C249/02 , C07C303/34 , C07C2601/04 , C07D453/04 , C07C307/02 , C07C211/29 , C07C251/16
摘要： This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
摘要翻译： 本发明提供了可用于制备胺立体异构体的方法的中间体。 它还提供了使用某些中间体制备亚砜和亚磺酰胺立体异构体的方法。
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公开(公告)号：US07256297B2
公开(公告)日：2007-08-14
申请号：US11340551
申请日：2006-01-27
申请人： Chris Hugh Senanayake , Zhengxu Han , Dhileepkumar Krishnamurthy , Derek Pflum , Harold Scott Wilkinson
发明人： Chris Hugh Senanayake , Zhengxu Han , Dhileepkumar Krishnamurthy , Derek Pflum , Harold Scott Wilkinson
IPC分类号： C07D291/04
CPC分类号： C07D291/04 , C07B2200/07 , C07C303/36 , C07C313/04 , C07C315/00 , C07C317/04 , C07C2602/08 , C07D235/28 , C07D291/08 , C07D401/12 , C07C317/14 , C07C311/03
摘要： This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
摘要翻译： 本发明包括制备亚磺酰胺和亚砜，特别是立体异构纯的亚磺酰胺和亚砜的新方法。 本发明还包括可以制备亚磺酰胺和亚砜的新化合物。
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公开(公告)号：US20060287539A1
公开(公告)日：2006-12-21
申请号：US11514141
申请日：2006-09-01
IPC分类号： C07D207/30
CPC分类号： C07D291/04 , C07B2200/07 , C07C209/52 , C07C249/02 , C07C303/34 , C07C2601/04 , C07D453/04 , C07C307/02 , C07C211/29 , C07C251/16
摘要： This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
摘要翻译： 本发明提供了可用于制备胺立体异构体的方法的中间体。 它还提供了使用某些中间体制备亚砜和亚磺酰胺立体异构体的方法。
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公开(公告)号：US20060128767A1
公开(公告)日：2006-06-15
申请号：US11340551
申请日：2006-01-27
IPC分类号： C07D291/02 , A61K31/433
CPC分类号： C07D291/04 , C07B2200/07 , C07C303/36 , C07C313/04 , C07C315/00 , C07C317/04 , C07C2602/08 , C07D235/28 , C07D291/08 , C07D401/12 , C07C317/14 , C07C311/03
摘要： This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
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公开(公告)号：US20050165240A1
公开(公告)日：2005-07-28
申请号：US10508941
申请日：2003-04-07
IPC分类号： A61K31/137 , A61P3/04 , A61P43/00 , C07B53/00 , C07C209/30 , C07C209/52 , C07C211/29 , C07C249/02 , C07C251/16 , C07C301/00 , C07C303/34 , C07C307/02 , C07C311/17 , C07C313/04 , C07C313/06 , C07C315/00 , C07C317/04 , C07C317/14 , C07C317/44 , C07D291/04 , C07D453/04 , C07D285/14
CPC分类号： C07D291/04 , C07B2200/07 , C07C209/52 , C07C249/02 , C07C303/34 , C07C2601/04 , C07D453/04 , C07C307/02 , C07C211/29 , C07C251/16
摘要： This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.
摘要翻译： 本发明提供一种制备胺立体异构体的方法，其包括立体选择性还原亚磺酰亚胺，其在亚磺酰基上具有醇，硫醇或胺的残基，或使亚磺酰基上的亚硫酰亚胺立体异构体与醇的残基反应，硫醇 或具有亲核试剂来源的胺，得到亚磺酰胺立体异构体，然后使亚磺酰胺立体异构体与适合于硫 - 氮键切割的试剂接触，得到胺立体异构体。 它还提供了可用于该方法的新型中间体，以及某些中间体在制备亚砜和亚磺酰胺立体异构体中的用途。
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