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公开(公告)号：US09885090B2
公开(公告)日：2018-02-06
申请号：US14485488
申请日：2014-09-12
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C07K16/28 , C07K14/705 , C07K16/30 , A61K39/395 , C07K14/725 , C12Q1/68 , C12N15/86 , C12N7/00 , G01N33/574
CPC分类号： C12Q1/6897 , C12N7/00 , C12N15/86 , C12N2710/10045 , C12N2710/10331 , C12N2710/10343 , C12N2830/008 , C12N2830/85 , G01N33/57415 , G01N33/57492 , G01N2800/7028
摘要： Compositions and methods for detecting a cancer in a subject using a recombinant reporter adenovirus are described. In particular, recombinant adenovirus is used to diagnose a cancer in a patient and further used for screening compounds effective in treating the cancer in said patient.
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公开(公告)号：US20150017127A1
公开(公告)日：2015-01-15
申请号：US14485472
申请日：2014-09-12
CPC分类号： A61K35/761 , C07K2319/20 , C12N7/00 , C12N15/86 , C12N2710/10034 , C12N2710/10052 , C12N2710/10345
摘要： Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic acid comprising a capsid-dimerizing agent binder conjugate and a ligand-dimerizing agent binder conjugate is provided.
摘要翻译： 描述了使用化学二聚体将腺病毒重新靶向细胞的组合物和方法。 特别地，提供了包含包含衣壳二聚化剂粘合剂缀合物和配体 - 二聚体粘合剂缀合物的核酸的重组腺病毒。
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公开(公告)号：US20150005397A1
公开(公告)日：2015-01-01
申请号：US14485488
申请日：2014-09-12
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12Q1/68 , C12N7/00 , G01N33/574 , C12N15/86
CPC分类号： C12Q1/6897 , C12N7/00 , C12N15/86 , C12N2710/10045 , C12N2710/10331 , C12N2710/10343 , C12N2830/008 , C12N2830/85 , G01N33/57415 , G01N33/57492 , G01N2800/7028
摘要： Compositions and methods for detecting a cancer in a subject using a recombinant reporter adenovirus are described. In particular, recombinant adenovirus is used to diagnose a cancer in a patient and further used for screening compounds effective in treating the cancer in said patient.
摘要翻译： 描述了使用重组报告基因腺病毒检测受试者的癌症的组合物和方法。 特别地，重组腺病毒用于诊断患者的癌症，并进一步用于筛选有效治疗所述患者的癌症的化合物。
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公开(公告)号：US20240342231A1
公开(公告)日：2024-10-17
申请号：US18426803
申请日：2024-01-30
IPC分类号： A61K35/761 , C12N7/00 , C12N15/86
CPC分类号： A61K35/761 , C12N7/00 , C12N15/86 , C07K2319/20 , C12N2710/10034 , C12N2710/10052 , C12N2710/10345
摘要： Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic acid comprising a capsid-dimerizing agent binder conjugate and a ligand-dimerizing agent binder conjugate is provided.
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公开(公告)号：US20220090123A1
公开(公告)日：2022-03-24
申请号：US17459095
申请日：2021-08-27
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/85 , C07K14/005 , C12N7/00 , C07K14/075 , C12N15/62
摘要： Recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in high-throughput assays to measure virus replication kinetics. Methods for measuring replication kinetics of a recombinant adenovirus are also described.
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26.发明申请公开(公告)号：US20200325492A1
公开(公告)日：2020-10-15
申请号：US16916764
申请日：2020-06-30
发明人： Clodagh O'Shea , William Partlo , Colin Powers
IPC分类号： C12N15/86
摘要： Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.
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公开(公告)号：US09913866B2
公开(公告)日：2018-03-13
申请号：US14485472
申请日：2014-09-12
IPC分类号： A61K35/76 , C12N7/00 , C12N15/861 , A61K35/761 , C12N15/86
CPC分类号： A61K35/761 , C07K2319/20 , C12N7/00 , C12N15/86 , C12N2710/10034 , C12N2710/10052 , C12N2710/10345
摘要： Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic acid comprising a capsid-dimerizing agent binder conjugate and a ligand-dimerizing agent binder conjugate is provided.
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公开(公告)号：US20130243729A1
公开(公告)日：2013-09-19
申请号：US13768933
申请日：2013-02-15
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12N7/04
CPC分类号： C12N7/04 , A61K35/761 , C12N7/00 , C12N2710/10322 , C12N2710/10332
摘要： Anti-cancer adenoviruses, methods of use and methods of making the same are provided herein.
摘要翻译： 本文提供抗癌腺病毒，使用方法及其制备方法。
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公开(公告)号：US20130231267A1
公开(公告)日：2013-09-05
申请号：US13769025
申请日：2013-02-15
发明人： Clodagh O'Shea , Colin Powers
IPC分类号： C12N15/861
CPC分类号： C12N7/00 , C12N15/86 , C12N15/861 , C12N2710/10043 , C12N2710/10051 , C12N2710/10351 , C12N2800/30 , C12N2800/70
摘要： Methods of assembling modified adenoviruses, libraries of adenoviral gene modules and compositions thereof are provided herein.
摘要翻译： 本文提供了组装修饰的腺病毒的方法，腺病毒基因模块的文库及其组合物。
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