公开(公告)号：US11542552B2

公开(公告)日：2023-01-03

申请号：US16909827

申请日：2020-06-23

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Kim Yang Lee ,  Thomas Young Chang ,  David S. Kuo ,  ShuaiGang Xiao ,  Xiaomin Yang ,  Koichi Wago

IPC: B81C1/00 ,  B01L3/00 ,  G01N27/327 ,  C12Q1/6869 ,  G01N27/447

Abstract: A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.

公开(公告)号：US11377686B2

公开(公告)日：2022-07-05

申请号：US16935111

申请日：2020-07-21

Applicant: Seagate Technology LLC

Inventor： Thomas Young Chang

IPC: C12Q1/6869 ,  G01N33/487

Abstract: A DNA sequencing device having a first conductor electrically insulated from a second conductor, a voltage source and an amplifier electrically connected in series with the first conductor and the second conductor, a DNA polymerase attached to the first conductor and to the second conductor with matching biotinylated tag molecules, and an electric current monitor. A non-discriminating electrical signal is provided by the polymerase during pairing, which signal can be used as a marker to indicate that transcription is occurring between a single-type of free nucleotide and a base nucleotide of a template DNA strand.

公开(公告)号：US11320397B2

公开(公告)日：2022-05-03

申请号：US16940486

申请日：2020-07-28

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Thomas Young Chang ,  David S. Kuo ,  Kim Yang Lee ,  Koichi Wago

IPC: G01N27/447 ,  B01L3/00 ,  G01N33/487 ,  C12Q1/6869 ,  B82Y15/00 ,  B82Y30/00

Abstract: A DNA sequencing device, and related method, which include an electrode and a plurality of spaced apart alignment structures. The electrode defines an electrode gap, the electrode being operable to detect a change in tunneling current as a DNA strand passes through the electrode gap. The plurality of spaced apart alignment structures are arranged to position nucleotides of the DNA strand in a predetermined orientation as the DNA strand passes through the electrode gap.

公开(公告)号：US10889857B2

公开(公告)日：2021-01-12

申请号：US15886533

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Xiaomin Yang ,  ShuaiGang Xiao ,  David S. Kuo ,  Koichi Wago ,  Thomas Young Chang

IPC: C12Q1/6869 ,  B82Y15/00 ,  C12M1/34

Abstract: Apparatus and methods relating to DNA sequencing are provided. In one embodiment, a DNA sequencing device includes a nanochannel having a width that is approximately 0.3 nm to approximately 20 nm. A pair of electrodes having portions exposed to the nanochannel may form a tunneling current electrode (TCE) with an electrode gap of approximately 0.1 nm to approximately 2 nm, and more particularly about 0.3 nm to about 1 nm. In one embodiment, at least one of the pair of electrodes is formed as a suspended electrode. An actuator may be associated with the suspended electrode to displace it relative to the other electrode. In various embodiments, the nanochannel and/or the electrodes may be formed using thermal reflow processes to reduce the size of such features.

公开(公告)号：US10731210B2

公开(公告)日：2020-08-04

申请号：US15886511

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Kim Yang Lee ,  Thomas Young Chang ,  David S. Kuo ,  ShuaiGang Xiao ,  Xiaomin Yang ,  Koichi Wago

IPC: G01N27/327 ,  C12Q1/6869 ,  B81C1/00 ,  G01N27/447 ,  B01L3/00

Abstract: A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode, and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.

公开(公告)号：US09245566B2

公开(公告)日：2016-01-26

申请号：US14154018

申请日：2014-01-13

Applicant: Seagate Technology LLC

Inventor： Shuaigang Xiao ,  Thomas Young Chang ,  Yingguo Peng ,  David S. Kuo ,  Kaizhong Gao ,  Thomas P. Nolan ,  Ganping Ju

IPC: G11B5/66 ,  G11B5/73 ,  G11B5/855 ,  G11B5/84

CPC classification number: G11B5/7325 ,  G11B5/84 ,  G11B5/855

Abstract: A perpendicular magnetic media includes a substrate, a patterned template, a seed layer and a magnetic layer. The patterned template is formed on the substrate and includes a plurality of growth sites that are evenly spaced apart from each other. The seed layer is formed over the patterned template and the exposed areas of the substrate. Magnetic material is sputter deposited onto the seed layer with one grain of the magnetic material nucleated over each of the growth sites. The grain size distribution of the magnetic material is reduced by controlling the locations of the growth sites which optimizes the performance of the perpendicular magnetic media.

Abstract translation: 垂直磁性介质包括衬底，图案化模板，种子层和磁性层。 图案化模板形成在基板上并且包括彼此均匀间隔开的多个生长位点。 种子层形成在图案化模板和基板的暴露区域上。 将磁性材料溅射沉积到种子层上，其中一颗磁性材料成核在每个生长位点上。 通过控制优化垂直磁性介质性能的生长部位的位置来减小磁性材料的粒度分布。