公开(公告)号：US20160068061A1

公开(公告)日：2016-03-10

申请号：US14943438

申请日：2015-11-17

申请人： Sean Whelan ,  Robert Tate ,  Brian Scott

发明人： Sean Whelan ,  Robert Tate ,  Brian Scott

IPC分类号： B60K15/035 ,  B60K15/04

CPC分类号： B60K15/03519 ,  B60K15/0406 ,  B60K2015/03585 ,  F02M37/0076 ,  Y10T29/49826 ,  Y10T29/4998

摘要： Pressure relief apparatus for use with fuel delivery systems are described herein. An example pressure relief apparatus includes a body defining a cavity and an annular wall projecting from a lower surface of the cavity. A first valve includes a first valve body defining a first flow passage between a first inlet to be oriented toward atmospheric pressure and a first outlet to be oriented toward a fuel tank. The first valve body houses a first flow control member to control fluid flow through the first flow passage between the first inlet and the first outlet. The first valve body projects from the lower surface of the cavity and toward an upper surface of the annular wall a distance substantially equal to a depth between the lower surface and the upper surface of the annular wall.

摘要翻译： 本文描述了用于燃料输送系统的压力释放装置。 示例性压力释放装置包括限定空腔的主体和从空腔的下表面突出的环形壁。 第一阀包括第一阀体，其在朝向大气压的第一入口和朝向燃料箱的第一出口之间限定第一流动通道。 第一阀体容纳第一流量控制构件以控制通过第一入口和第一出口之间的第一流动通道的流体流动。 第一阀体从空腔的下表面突出到环形壁的上表面，该距离基本上等于环形壁的下表面和上表面之间的深度。

公开(公告)号：US09234885B2

公开(公告)日：2016-01-12

申请号：US13979179

申请日：2012-01-24

申请人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

发明人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

IPC分类号： G01N33/50 ,  A61K31/55 ,  A61K31/566 ,  C12Q1/70 ,  G01N33/569 ,  A61K31/5685

CPC分类号： G01N33/5035 ,  A61K31/55 ,  A61K31/566 ,  A61K31/5685 ,  C12N2760/14034 ,  C12N2760/14111 ,  C12N2760/14211 ,  C12N2760/20243 ,  C12Q1/70 ,  G01N33/56983

摘要： Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.

摘要翻译： 使用抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4的药物治疗患有病毒感染的受试者的方法和测定法。 用于筛选治疗和/或预防患有病毒感染受试者的药剂的方法，其中所述方法包括确定该药物是否抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39中的一种或多种 ，VPS41。 BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4，其中抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4中的一种或多种的药剂是 治疗和/或预防感染病毒，并且其中不抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A的药剂。 VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4不是用于治疗和/或预防感染病毒的候选物。

公开(公告)号：US09096124B2

公开(公告)日：2015-08-04

申请号：US12061183

申请日：2008-04-02

申请人： Sean Whelan ,  Steven E. Hovinga

发明人： Sean Whelan ,  Steven E. Hovinga

IPC分类号： B65D51/16 ,  B60K15/04 ,  B60K15/035

CPC分类号： B60K15/0406 ,  B60K15/035 ,  B60K15/03504 ,  B60K2015/03509 ,  B60K2015/03547 ,  B60K2015/0451

摘要： Fuel cap apparatus for use with fuel venting systems are described. An example fuel cap apparatus includes a body having a central cavity and a flange. A membrane is coupled to the body to form a passageway therethrough and coated with a material to substantially prevent the flow of liquid and permit the flow of gas through the passageway.

摘要翻译： 描述了与燃油排放系统一起使用的燃油盖装置。 一个示例性燃料盖装置包括具有中心腔体和凸缘的主体。 膜连接到主体以形成穿过其中的通道并涂覆有材料，以基本上防止液体的流动并允许气体流过通道。

公开(公告)号：US20140018338A1

公开(公告)日：2014-01-16

申请号：US13979179

申请日：2012-01-24

申请人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

发明人： Kartik Chandran ,  Sean Whelan ,  Thijn Brummelkamp ,  Jan Carette ,  Matthijs Raaben

IPC分类号： G01N33/50 ,  A61K31/55 ,  A61K31/566 ,  C12Q1/70 ,  G01N33/569

CPC分类号： G01N33/5035 ,  A61K31/55 ,  A61K31/566 ,  A61K31/5685 ,  C12N2760/14034 ,  C12N2760/14111 ,  C12N2760/14211 ,  C12N2760/20243 ,  C12Q1/70 ,  G01N33/56983

摘要： Methods and assays for treating a subject with a filovirus infection using an agent that inhibits Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4. Methods for screening for an agent that treats and/or prevents infection of a subject with a filovirus, where the methods comprise determining whether the agent inhibits one or more of Niemann-Pick CI (NPCI), VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41. BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4, wherein an agent that inhibits one or more of NPCI, VPSII, VPSI6, VPSI8, VPS33A, VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is a candidate for treating and/or preventing an infection with a filovirus and wherein an agent that does not inhibit NPCI, VPSII, VPSI6, VPSI8, VPS33A. VPS39, VPS41, BLOCISI, BLOCIS2, GNPTAB, PIKFYVE, ARHGAP23 or FIG4 is not a candidate for treating and/or preventing an infection with a filovirus.

摘要翻译： 使用抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4的药物治疗患有病毒感染的受试者的方法和测定法。 用于筛选治疗和/或预防患有病毒感染受试者的药剂的方法，其中所述方法包括确定该药物是否抑制Niemann-Pick CI（NPCI），VPSII，VPSI6，VPSI8，VPS33A，VPS39中的一种或多种 ，VPS41。 BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4，其中抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A，VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4中的一种或多种的药剂是 治疗和/或预防感染病毒，并且其中不抑制NPCI，VPSII，VPSI6，VPSI8，VPS33A的药剂。 VPS39，VPS41，BLOCISI，BLOCIS2，GNPTAB，PIKFYVE，ARHGAP23或FIG4不是用于治疗和/或预防感染病毒的候选物。

公开(公告)号：US20110084073A1

公开(公告)日：2011-04-14

申请号：US12793009

申请日：2010-06-03

申请人： Sean Whelan ,  Robert Tate ,  Brian Scott

发明人： Sean Whelan ,  Robert Tate ,  Brian Scott

IPC分类号： B65D41/04 ,  B23P11/00

CPC分类号： B60K15/03519 ,  B60K15/0406 ,  B60K2015/03585 ,  F02M37/0076 ,  Y10T29/49826 ,  Y10T29/4998

摘要： Apparatus and methods for mounting fuel delivery system components to fuel tanks are described herein. An example fuel tank includes a housing having a cavity to store a liquid fuel and a boss integrally formed with and protruding from a surface of the housing to receive a fuel delivery system component. The boss receives a threaded fastener to couple the fuel delivery system component to the surface of the fuel tank.

摘要翻译： 这里描述了用于将燃料输送系统组件安装到燃料箱的装置和方法。 一个示例性的燃料箱包括具有空腔以存储液体燃料的壳体和与壳体的表面一体地形成并从壳体的表面突出以接收燃料输送系统部件的凸台。 凸台接收螺纹紧固件以将燃料输送系统部件连接到燃料箱的表面。

公开(公告)号：US20110083989A1

公开(公告)日：2011-04-14

申请号：US12793005

申请日：2010-06-03

申请人： Sean Whelan ,  Robert Tate ,  Brian Scott

发明人： Sean Whelan ,  Robert Tate ,  Brian Scott

IPC分类号： B65D85/84 ,  B23P17/00

CPC分类号： B60K15/03519 ,  B60K15/0406 ,  B60K2015/03585 ,  F02M37/0076 ,  Y10T29/49826 ,  Y10T29/4998

摘要： Apparatus and methods to permanently attach fuel delivery system components to fuel tanks are described herein. An example apparatus includes an insert material integrally formed with at least a portion of the fuel tank. The insert material includes a first layer material having a low permeation characteristic and a second layer material adjacent the first layer material having a relatively lower melting point than a melting point of the first layer material to enable permanent attachment of a coupling apparatus to a surface of the fuel tank by melting at least a portion of the second layer material.

摘要翻译： 本文描述了将燃料输送系统部件永久地附接到燃料箱的装置和方法。 示例性装置包括与燃料箱的至少一部分一体形成的插入材料。 插入材料包括具有低渗透特性的第一层材料和邻近第一层材料的第二层材料，其具有比第一层材料的熔点相对较低的熔点，以使得能够将耦合装置永久地附接到 所述燃料箱通过熔化所述第二层材料的至少一部分。

公开(公告)号：US20110083772A1

公开(公告)日：2011-04-14

申请号：US12793001

申请日：2010-06-03

申请人： Sean Whelan ,  Robert Tate ,  Brian Scott

发明人： Sean Whelan ,  Robert Tate ,  Brian Scott

IPC分类号： B65B1/04 ,  B23P11/00 ,  B65D90/00

CPC分类号： B60K15/03519 ,  B60K15/0406 ,  B60K2015/03585 ,  F02M37/0076 ,  Y10T29/49826 ,  Y10T29/4998

摘要： Apparatus and methods to couple fuel delivery system components to fuel tanks are described herein. An example liquid containment apparatus includes a fuel tank having a cavity to store a liquid fuel. The fuel tank includes only one opening in fluid communication with the cavity. A coupling apparatus is coupled to a portion of the fuel tank to provide a passage between an exterior surface of the fuel tank and the cavity. The coupling receives a plurality of components of a fuel delivery system.

摘要翻译： 这里描述了将燃料输送系统组件连接到燃料箱的装置和方法。 示例性液体容纳设备包括具有用于存储液体燃料的空腔的燃料箱。 燃料箱仅包括与空腔流体连通的一个开口。 联接装置联接到燃料箱的一部分，以在燃料箱的外表面和空腔之间提供通道。 联接器接收燃料输送系统的多个部件。

公开(公告)号：US20100010393A1

公开(公告)日：2010-01-14

申请号：US12169448

申请日：2008-07-08

申请人： Niall Duffy ,  Richard Houben ,  Ashish Varma ,  Sean Whelan

发明人： Niall Duffy ,  Richard Houben ,  Ashish Varma ,  Sean Whelan

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B17/22004 ,  A61B2017/00106 ,  A61B2017/00703

摘要： An apparatus for treating an occlusion in a vessel inside of a patient. The apparatus includes an external high intensity focused ultrasound transducer configured to be positioned outside of the vessel and to emit ultrasonic waves of energy to the occlusion and to detect ultrasonic waves of energy, an internal ultrasound transducer configured to be positioned inside of the vessel at a position adjacent to or inside the occlusion and to emit ultrasonic waves of energy for detection by the external high intensity focused ultrasound transducer, and a controller configured to control the ultrasonic waves of energy emitted by the external high intensity focused ultrasound transducer based on an electrocardiogram of the patient.

摘要翻译： 一种用于治疗患者体内血管闭塞的装置。 该装置包括外部高强度聚焦超声波换能器，其被配置为位于血管外部并且向闭塞发射能量的超声波并检测能量的超声波;内部超声波换能器被配置为定位在血管内部 位于与闭塞相邻或内部的位置，并且发射超声波能量以供外部高强度聚焦超声波换能器检测;以及控制器，被配置为基于外部高强度聚焦超声波换能器的心电图 患者。

公开(公告)号：US5976181A

公开(公告)日：1999-11-02

申请号：US934703

申请日：1997-09-22

申请人： Sean Whelan ,  Neil Purcell ,  Thomas Fitzmaurice

发明人： Sean Whelan ,  Neil Purcell ,  Thomas Fitzmaurice

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61M29/00

CPC分类号： A61F2/958 ,  A61F2002/9583 ,  A61M2025/1086

摘要： The present invention concerns a mechanism for securely mounting an expandable stent onto a balloon catheter for intraluminal delivery within a patient. The stent is secured to the balloon of the delivery catheter by forming the surface of the balloon to project into the interstices of the stent. To mount the stent it first is slid over an evacuated and wrapped balloon while in its compact delivery diameter. A rigid tube then is placed over the stent and balloon assembly and the balloon is pressurized while a solvent is applied to the balloon. The rigid tube prevents the stent from expanding but allows the balloon to deform so that its surface projects slightly through either or both of the interstices and ends of the stent. The solvent causes the balloon material to take a permanent set into the stent such that once pressure is removed, the stent is interlocked with the surface of the balloon. The engagement of the stent with the balloon prevents unintended axial sliding of the stent with respect to the balloon during delivery through the vessel of the patient.

摘要翻译： 本发明涉及一种用于将可扩张支架牢固地安装到气囊导管上以用于在患者体内进行腔内输送的机构。 通过形成气囊的表面将支架固定到输送导管的球囊，以投射到支架的间隙中。 为了安装支架，它首先在其紧凑的输送直径的同时在真空和包裹的气囊上滑动。 然后将刚性管放置在支架和球囊组件上方，并且在将溶剂施加到气囊的同时对气囊进行加压。 刚性管防止支架膨胀，但允许气囊变形，使得其表面略微突出穿过支架的间隙和末端。 溶剂导致气囊材料将永久性固定装置固定在支架中，使得一旦除去压力，则支架与气囊的表面互锁。 支架与气囊的接合防止在通过患者血管的输送期间支架相对于气囊的意外轴向滑动。