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公开(公告)号：US20080039784A1
公开(公告)日：2008-02-14
申请号：US11877222
申请日：2007-10-23
申请人： David Quinn , Ashish Varma
发明人： David Quinn , Ashish Varma
IPC分类号： A61M25/10
CPC分类号： A61M25/0029 , A61M25/0023 , A61M25/0032 , A61M25/0051 , A61M25/0053 , A61M2025/0036
摘要： A multi-lumen catheter with a generally circular cross-section having a central guidewire lumen, partially circumscribed by an inflation lumen having a generally C-shaped cross-section defining a web and a guidewire access cut extending radially through that web from the outer surface of the multi-lumen catheter to the central guidewire lumen. The guidewire access cut allowing access to an indwelling guidewire for direct control over axial translation, or ingress and egress of the guidewire.
摘要翻译： 具有大致圆形横截面的多腔导管，其具有中心导丝管腔，部分地由具有限定腹板的大致C形横截面的充气腔内接，以及从外表面径向穿过该腹板的导丝通路切口 的多腔导管连接到中心导丝管腔。 引导线进入切割允许访问留置导丝，以直接控制轴向平移，或导丝的进入和流出。
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公开(公告)号：US20050069452A1
公开(公告)日：2005-03-31
申请号：US10671946
申请日：2003-09-29
申请人： Ashish Varma , Frank Clarke
发明人： Ashish Varma , Frank Clarke
CPC分类号： A61L2/087 , A61L2/081 , A61L29/14 , A61L2202/24 , B32B27/12 , B32B27/34 , B32B27/36 , B32B2250/40 , B32B2307/74 , B32B2439/80 , B65B55/16
摘要： A sterilization process that preserves the mechanical properties of dilatation balloons and balloon catheters manufactured from polymers susceptible to the degradation reactions induced by ionizing radiation. The advantages of the sterilization process contemplated by this invention results from a reduced oxygen environment during sterilization, thereby preventing the degeneration process initiated in polymers during irradiation. Additionally, a balloon or balloon dilatation catheter sterilized by the process of the invention is provided.
摘要翻译： 一种灭菌方法，其保持由对由电离辐射引起的降解反应敏感的聚合物制造的膨胀气囊和球囊导管的机械性能。 本发明考虑的灭菌方法的优点是由于灭菌过程中的氧气环境减少，从而防止在照射期间在聚合物中引发的退化过程。 另外，提供了通过本发明的方法消毒的球囊或球囊扩张导管。
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公开(公告)号：US20070191767A1
公开(公告)日：2007-08-16
申请号：US11695697
申请日：2007-04-03
申请人： Joe Hennessy , Ashish Varma , Robert Murray , Gerry Clarke , Terry Guinan , Patrick Duane
发明人： Joe Hennessy , Ashish Varma , Robert Murray , Gerry Clarke , Terry Guinan , Patrick Duane
CPC分类号： A61M25/0009 , A61F2/95 , A61F2240/001 , A61M25/0023 , A61M25/0029 , A61M25/0032 , A61M25/10 , A61M2025/0183 , A61M2025/1045
摘要： A rapid exchange catheter includes an exchange joint that is coupled between a proximal shaft and first and second distal shafts. The exchange joint includes a proximal end that is configured to be coupled to the proximal shaft, and a distal end that is configured to be coupled to the first distal shaft and the second distal shaft. The distal end includes a first portion that includes a first guidewire lumen, and a second portion that includes a second guidewire lumen. The exchange joint also includes a guidewire port that is configured to provide access for a first guidewire into the first distal inner lumen via the first guidewire lumen and a second guidewire into the second distal inner lumen via the second guidewire lumen.
摘要翻译： 快速交换导管包括耦合在近端轴和第一和第二远端轴之间的交换接头。 交换接头包括构造成联接到近侧轴的近端，以及构造成联接到第一远端轴和第二远端轴的远端。 远端包括包括第一导丝管腔的第一部分和包括第二导丝管腔的第二部分。 所述交换接头还包括导丝端口，所述导丝端口被构造成经由所述第一导丝管线将第一导丝提供到所述第一远端内腔中，并且经由所述第二导丝管线将第二导丝提供到所述第二远端内腔中。
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公开(公告)号：US20060135948A1
公开(公告)日：2006-06-22
申请号：US11015272
申请日：2004-12-16
申请人： Ashish Varma
发明人： Ashish Varma
IPC分类号： A61M25/00
CPC分类号： A61M25/09041 , A61M25/0029 , A61M25/0032 , A61M2025/09116 , A61M2025/09125
摘要： A catheter and a guidewire exchange system includes a catheter and a guide member. The catheter includes a lumen extending through the shaft and sized to receive the guidewire, and a longitudinal guideway enabling transverse access from the shaft exterior surface to the lumen. The guide member includes a housing, a catheter passageway extending through the housing and adapted to slidably receive the catheter, a guidewire passageway extending from one end of the housing into the catheter passageway and including a tube adapted to merge the guidewire transversely through the guideway and into the first lumen, and a user-activated device positioned in the guidewire passageway and including a clamping body adapted to clamp the guidewire and thereby secure the guidewire in the guidewire passageway.
摘要翻译： 导管和导丝交换系统包括导管和引导构件。 导管包括延伸穿过轴并且尺寸适于接纳导丝的腔，以及能够从轴外表面到内腔的横向进入的纵向导轨。 引导构件包括壳体，延伸穿过壳体并适于滑动地容纳导管的导管通道，从壳体的一端延伸到导管通道中并且包括适于将导丝横穿导轨并入导管的导管， 以及位于导丝通道中的用户激活的装置，并且包括适于夹紧导丝的夹持主体，从而将导丝固定在导丝通道中。
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5.发明申请Hyper-elastic, high strength dilatation balloon made from multi-block copolymers 审中-公开由多嵌段共聚物制成的超弹性高强度膨胀球囊公开(公告)号：US20050118370A1
公开(公告)日：2005-06-02
申请号：US10920457
申请日：2004-08-18
申请人： Ashish Varma , Kimberly Chaffin
发明人： Ashish Varma , Kimberly Chaffin
IPC分类号： A61L29/00 , A61L29/04 , A61M25/00 , B29C47/00 , B29C55/04 , B29C55/12 , B29C71/00 , B65D1/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A self-wrapping dilatation balloon comprising a multiblock copolymer having high elasticity and elastic recovery from nominal strains greater than about 30% is described. Also described herein, is a polymeric extrudate for making a dilatation balloon comprising a multiblock copolymer having tensile strength in the range of about 50 MPa to about 450 MPa, strain at break in the range of about 50% to about 600% and substantially complete elastic recovery from nominal strains of at least about 30%. The extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. Also described herein is a process for producing a polymeric extrudate for use as a dilatation balloon. The process comprises extruding a multiblock copolymer mixture or composition to form an extrudate. The extruding is done such that the extrudate has phase-separated microdomains that are macroscopically aligned in parallel, perpendicular, transverse or a combination thereof. After extrusion, the process optionally comprises the steps of drawing and coagulating the extrudate.
摘要翻译： 描述了包含具有高于约30％的标称应变的高弹性和弹性恢复的多嵌段共聚物的自包裹膨胀气球。 本文还描述了一种用于制造膨胀气囊的聚合物挤出物，其包含具有约50MPa至约450MPa范围内的拉伸强度，约50％至约600％范围内的拉伸应变和基本上完全弹性的多嵌段共聚物 从名义菌株中恢复至少约30％。 挤出物具有相分离的微区域，它们在宏观上对齐，平行，垂直，横向或其组合。 本文还描述了用于生产用作膨胀气球的聚合物挤出物的方法。 该方法包括挤出多嵌段共聚物混合物或组合物以形成挤出物。 进行挤出使得挤出物具有相互分离的微区域，其宏观地对准在平行，垂直，横向或其组合。 挤出后，该方法任选地包括拉伸和凝结挤出物的步骤。
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公开(公告)号：US20050070880A1
公开(公告)日：2005-03-31
申请号：US10808440
申请日：2004-03-25
申请人： Ashish Varma , Noel Coyle , Richard Gribbons
发明人： Ashish Varma , Noel Coyle , Richard Gribbons
CPC分类号： A61M25/0023 , A61M25/0052 , A61M25/0053 , A61M25/0054 , A61M2025/0063 , A61M2025/0183 , A61M2025/107
摘要： A catheter having a proximal shaft defining a guidewire lumen and an inflation lumen. The inflation lumen is arcuate shaped and reinforced with a tube having an arcuate shaped cross-section or another reinforcing means. The catheter also has a distal shaft, with a greater flexibility than the proximal shaft. The catheter also has a transition section. A proximal end of the transition section communicates with the proximal shaft, and a distal end communicating with the distal shaft. The transition section has a gradually increased flexibility from its proximal end to its distal end. The transition section includes a transition means creating the increased flexibility.
摘要翻译： 具有限定导丝管腔和充气腔的近端轴的导管。 充气腔是弧形的，并用具有弓形截面的管或另一个加强装置加强。 导管还具有远端轴，其具有比近侧轴更大的灵活性。 导管还具有过渡部分。 过渡部分的近端与近侧轴连通，远端与远侧轴连通。 过渡部分从其近端到其远端具有逐渐增加的柔性。 过渡部分包括产生增加的灵活性的过渡装置。
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公开(公告)号：US09292266B2
公开(公告)日：2016-03-22
申请号：US13641279
申请日：2010-04-30
申请人： Giovanni Motta , Sait Can Saydag , Ashish Varma , Fu Jun Wu
发明人： Giovanni Motta , Sait Can Saydag , Ashish Varma , Fu Jun Wu
摘要： A method for updating a computer the includes converting a first computer the to executable byte code and receiving a second computer the that includes a change that distinguishes the second computer file from the first computer file. The method also includes converting the second computer the to executable byte code and comparing at least a portion of the executable byte code of the second computer file with at least a portion of the executable byte code of the first computer file. The method further includes inserting, into the executable byte code the first computer file, a modification that causes at least a portion of the executable byte code of the first computer the to resemble the executable byte code of the second computer file.
摘要翻译： 一种用于更新计算机的方法包括将第一计算机转换为可执行字节代码，并接收包括将第二计算机文件与第一计算机文件区分开的改变的第二计算机。 该方法还包括将第二计算机转换为可执行字节码，并将第二计算机文件的可执行字节码的至少一部分与第一计算机文件的可执行字节代码的至少一部分进行比较。 该方法还包括将第一计算机文件的可执行字节码的至少一部分与第二计算机文件的可执行字节码类似的修改，将第一计算机文件的可执行字节代码插入。
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公开(公告)号：US20130039252A1
公开(公告)日：2013-02-14
申请号：US13641279
申请日：2010-04-30
申请人： Giovanni Motta , Sait Can Saydag , Ashish Varma , Fu Jun Wu
发明人： Giovanni Motta , Sait Can Saydag , Ashish Varma , Fu Jun Wu
摘要： A method for updating a computer the includes converting a first computer the to executable byte code and receiving a second computer the that includes a change that distinguishes the second computer file from the first computer file. The method also includes converting the second computer the to executable byte code and comparing at least a portion of the executable byte code of the second computer file with at least a portion of the executable byte code of the first computer file. The method further includes inserting, into the executable byte code the first computer file, a modification that causes at least a portion of the executable byte code of the first computer the to resemble the executable byte code of the second computer file.
摘要翻译： 一种用于更新计算机的方法包括将第一计算机转换为可执行字节代码，并接收包括将第二计算机文件与第一计算机文件区分开的改变的第二计算机。 该方法还包括将第二计算机转换为可执行字节码，并将第二计算机文件的可执行字节码的至少一部分与第一计算机文件的可执行字节代码的至少一部分进行比较。 该方法还包括将第一计算机文件的可执行字节码的至少一部分与第二计算机文件的可执行字节码类似的修改，将第一计算机文件的可执行字节代码插入。
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9.发明授权Process for producing a hyper-elastic, high strength dilatation balloon made from multi-block copolymers 有权用于生产由多嵌段共聚物制成的超弹性高强度膨胀气球的方法公开(公告)号：US07879270B2
公开(公告)日：2011-02-01
申请号：US12869273
申请日：2010-08-26
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp transition from the first zone to the second zone.
摘要翻译： 通过挤出多嵌段共聚物组合物以形成包含相分离的玻璃状，橡胶和半结晶微区的挤出物的方法，所述挤出物以垂直对准的宏观顺序排列。 通过该过程形成的气球在充气过程中证明了真实应力与标称应变响应曲线，其包括代表低模量球囊的第一区域，代表高强度球囊的第二区域以及从第一区域到第 第二区。
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10.发明申请Process for Producing a Hyper-Elastic, High Strength Dilatation Balloon Made From Multi-Block Copolymers 有权用于生产由多嵌段共聚物制成的超弹性，高强度膨胀气球的方法公开(公告)号：US20100320634A1
公开(公告)日：2010-12-23
申请号：US12869273
申请日：2010-08-26
申请人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
发明人： Ashish Varma , Kimberly A. Chaffin , Frank Bates , Marc Hillmyer , Lisa Lim
IPC分类号： B29C47/00
CPC分类号： A61L29/04 , A61L29/049 , C08L53/00 , Y10T428/1352
摘要： A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp transition from the first zone to the second zone.
摘要翻译： 通过挤出多嵌段共聚物组合物以形成包含相分离的玻璃状，橡胶和半结晶微区的挤出物的方法，所述挤出物以垂直对准的宏观顺序排列。 通过该过程形成的气球在充气过程中证明了真实应力与标称应变响应曲线，其包括代表低模量球囊的第一区域，代表高强度球囊的第二区域以及从第一区域到第 第二区。
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