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公开(公告)号：US20100081791A1
公开(公告)日：2010-04-01
申请号：US12605028
申请日：2009-10-23
IPC分类号： C07K14/435
CPC分类号： A61K38/4846 , A61K47/549 , A61K47/60 , C12N9/644 , C12Y304/21022
摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。
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公开(公告)号：US20090081188A1
公开(公告)日：2009-03-26
申请号：US12184956
申请日：2008-08-01
CPC分类号： A61K38/4846 , A61K47/549 , A61K47/60 , Y02A50/471
摘要： The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译： 本发明提供因子IX和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。
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公开(公告)号：US08063015B2
公开(公告)日：2011-11-22
申请号：US12496595
申请日：2009-07-01
申请人： Shawn DeFrees , David A. Zopf , Robert J. Bayer , David James Hakes , Caryn L. Bowe , Xi Chen
发明人： Shawn DeFrees , David A. Zopf , Robert J. Bayer , David James Hakes , Caryn L. Bowe , Xi Chen
IPC分类号： A01N37/18
CPC分类号： A61K47/48215 , A61K38/1793 , A61K38/1816 , A61K38/185 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/24 , A61K38/36 , A61K38/40 , A61K38/465 , A61K38/47 , A61K38/482 , A61K38/4846 , A61K38/57 , A61K39/3955 , A61K47/549 , A61K47/60 , C07K5/1013 , C07K5/1016 , C07K9/00 , C07K9/008 , C07K14/00 , C07K16/241 , C07K2317/24 , C12N9/6424 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/96 , C12P21/005 , C12Y301/27005 , C12Y302/01045 , C12Y304/21021 , C12Y304/21022 , C12Y304/21068
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
摘要翻译： 本发明包括用于重组肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或向肽中加入修饰基团。
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公开(公告)号：US07842661B2
公开(公告)日：2010-11-30
申请号：US11440839
申请日：2006-05-25
IPC分类号： C07K14/00 , C07K14/505 , A61K38/00 , A61K38/16
CPC分类号： C07K14/505 , A61K38/1816 , A61K47/549 , A61K47/60
摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。
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公开(公告)号：US20080305992A1
公开(公告)日：2008-12-11
申请号：US11982273
申请日：2007-10-31
申请人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
发明人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
IPC分类号： C07K14/505 , A61K38/22 , C12P21/02 , A61P7/06 , A61P17/02
CPC分类号： C12P21/005 , A61K38/00 , A61K38/22
摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译： 本发明提供红细胞生成素和PEG部分之间的缀合物。 缀合物通过插入和共价连接到肽和修饰基团之间的完整糖基连接基团连接。 通过糖基转移酶的作用，由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。
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公开(公告)号：US08633157B2
公开(公告)日：2014-01-21
申请号：US11144223
申请日：2005-06-02
申请人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
发明人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
IPC分类号： A61K38/18 , A61P7/06 , C07K14/505
CPC分类号： A61K38/1816
摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
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公开(公告)号：US06030815A
公开(公告)日：2000-02-29
申请号：US628543
申请日：1996-04-10
申请人： Shawn DeFrees , Robert J. Bayer , Murray Ratcliffe
发明人： Shawn DeFrees , Robert J. Bayer , Murray Ratcliffe
CPC分类号： C07H15/04 , C12P19/26 , Y02P20/582
摘要： The present invention provides improved methods for the preparation of sialyl galactosides. The methods use sialyl transferase cycle in which the reaction conditions are optimized to provide increased yields.
摘要翻译： 本发明提供了制备唾液酰半乳糖苷的改进方法。 该方法使用唾液酸转移酶循环，其中优化反应条件以提高产率。
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公开(公告)号：US5728554A
公开(公告)日：1998-03-17
申请号：US419669
申请日：1995-04-11
申请人： Robert J. Bayer , Shawn DeFrees , Murray Ratcliffe
发明人： Robert J. Bayer , Shawn DeFrees , Murray Ratcliffe
CPC分类号： C12P19/26 , C12P19/18 , Y02P20/582
摘要： The present invention provides improved methods for the formation of glycosidic linkages. These methods are useful for the preparation of compounds of formula: NeuAc.alpha.(2.fwdarw.3)Gal.beta.(1.fwdarw.4)(Fuc.alpha. 1.fwdarw.3)GlcN(R').beta.(1.fwdarw.3)Gal.beta.-OR
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公开(公告)号：US20100330645A1
公开(公告)日：2010-12-30
申请号：US12784323
申请日：2010-05-20
申请人： Shawn DeFrees , David A. Zopf , Susann Taudte , Walter Scott Willett , Robert J. Bayer , Matthew Kalo
发明人： Shawn DeFrees , David A. Zopf , Susann Taudte , Walter Scott Willett , Robert J. Bayer , Matthew Kalo
IPC分类号： C12N9/96
CPC分类号： C12P21/005 , A61K38/4846
摘要： The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
摘要翻译： 本发明提供肽和PEG部分之间的缀合物。 缀合物经由完整的糖基连接基团连接，该基团介于并共价连接到肽和修饰基团之间。 通过糖基转移酶的作用，缀合物由糖基化和未糖基化的肽形成。 糖基转移酶将修饰的糖部分连接到肽上的氨基酸或糖基残基上。 还提供了包括缀合物的药物制剂。 缀合物的制备方法也在本发明的范围内。
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公开(公告)号：US07405198B2
公开(公告)日：2008-07-29
申请号：US10997405
申请日：2004-11-24
申请人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
发明人： Shawn DeFrees , Robert J. Bayer , David A. Zopf
CPC分类号： C07K14/505 , A61K38/00 , A61K47/60 , C07H19/10
摘要： The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
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