公开(公告)号：US08483808B2

公开(公告)日：2013-07-09

申请号：US12879147

申请日：2010-09-10

申请人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

发明人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC分类号： A61N5/0472 ,  A61B5/0452

CPC分类号： A61B5/04525 ,  G06K9/00536

摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

摘要翻译： 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US08078272B2

公开(公告)日：2011-12-13

申请号：US11625432

申请日：2007-01-22

申请人： Yayun Lin

发明人： Yayun Lin

IPC分类号： A61B5/0402

CPC分类号： A61B5/7221 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/7264 ,  A61N1/3704 ,  A61N1/3718

摘要： Detecting or validating signals such as cardiac beats can be performed in the presence of myopotential or other noise. An amplitude peak, which can be a candidate for a detected beat, can be used in a normalized or other weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result, the amplitude peak is either deemed an actual beat (e.g., depolarization or repolarization), or noise. The described systems, devices, and methods can improve the accuracy of detecting an actual beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable device.

摘要翻译： 检测或验证心脏搏动等信号可以在有电位或其他噪声的情况下进行。 可以作为检测到的拍子的候选者的振幅峰值可以与归一化或其他加权平均值一起使用，以及前一个和后续的采样。 将加权平均值与噪声阈值进行比较。 基于该结果，振幅峰值被认为是实际的搏动（例如去极化或复极化）或噪声。 所描述的系统，装置和方法可以提高在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际搏动的准确性。 这反过来又提高了可植入装置输送或保留治疗的准确性。

公开(公告)号：US20070239218A1

公开(公告)日：2007-10-11

申请号：US11277773

申请日：2006-03-29

申请人： Gerrard Carlson ,  Yayun Lin

发明人： Gerrard Carlson ,  Yayun Lin

IPC分类号： A61N1/365

CPC分类号： A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

摘要： A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The IMD also includes a heart sound sensor interface circuit to produce a heart sound signal, a tachyarrhythmia detector, and a controller circuit. The controller circuit includes a hemodynamic stability assessment module configured to determine that at least one episode of ventricular tachyarrhythmia is detected in a subject and obtain a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal.

摘要翻译： 一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。 IMD还包括产生心脏声音信号的心脏声音传感器接口电路，快速心律失常检测器和控制器电路。 控制器电路包括血液动力学稳定性评估模块，其被配置为确定在受试者中检测到至少一次心室快速性心律失常发作，并且从心脏声音信号获得心室快速性心律失常的血液动力学稳定性的测量。

公开(公告)号：US07215993B2

公开(公告)日：2007-05-08

申请号：US10213364

申请日：2002-08-06

申请人： Yayun Lin

发明人： Yayun Lin

IPC分类号： A61B5/0456

CPC分类号： A61B5/7221 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/7264 ,  A61N1/3704 ,  A61N1/3718

摘要： This document describes systems, devices, and methods for detecting or validating cardiac beats, such as in the presence of myopotential or other noise. In one example, an amplitude peak, which is a candidate for a detected cardiac beat, is used in a weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result of comparison, the amplitude peak is either deemed an actual cardiac beat, or otherwise is deemed noise. The described systems, devices, and methods improve the accuracy of detecting an actual cardiac beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable cardiac rhythm management device. In one example, such as where the system includes a cardiac signal detector with automatic gain control (AGC) circuitry, the weighted average is normalized.

摘要翻译： 本文件描述了用于检测或验证心脏搏动的系统，设备和方法，例如在存在神经或其他噪声的情况下。 在一个示例中，作为检测到的心跳的候选者的振幅峰值与加权平均值一起使用，以及之前和随后的样本。 将加权平均值与噪声阈值进行比较。 基于比较结果，振幅峰值被认为是实际心跳，或者被认为是噪声。 所描述的系统，装置和方法提高了在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际心搏的准确性。 这反过来又提高了植入式心律管理装置的治疗的输送或保留的准确性。 在一个示例中，例如系统包括具有自动增益控制（AGC）电路的心脏信号检测器的地方，加权平均值被归一化。

公开(公告)号：US20070049974A1

公开(公告)日：2007-03-01

申请号：US11209976

申请日：2005-08-23

申请人： Dan Li ,  Yayun Lin

发明人： Dan Li ,  Yayun Lin

IPC分类号： A61N1/00

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

摘要翻译： 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析患者治疗耐受性和医师输入中的一种或多种与心脏治疗相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US06539256B1

公开(公告)日：2003-03-25

申请号：US09611166

申请日：2000-07-06

申请人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

发明人： Bruce H. KenKnight ,  William Hsu ,  Yayun Lin ,  Janice Jones

IPC分类号： A61N139

CPC分类号： A61N1/3962

摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.

公开(公告)号：US08942791B2

公开(公告)日：2015-01-27

申请号：US13483387

申请日：2012-05-30

申请人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

发明人： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC分类号： A61B5/04 ,  A61N1/39

CPC分类号： A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

摘要： A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

摘要翻译： 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

公开(公告)号：US07938781B2

公开(公告)日：2011-05-10

申请号：US12813073

申请日：2010-06-10

申请人： Gerrard M. Carlson ,  Yayun Lin

发明人： Gerrard M. Carlson ,  Yayun Lin

IPC分类号： A61B5/02

CPC分类号： A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

摘要： A method comprises detecting at least one episode of ventricular tachyarrhythmia in a subject using an implantable medical device (IMD), sensing at least one heart sound signal for the subject using the IMD, the heart sound signal associated with mechanical vibration of a heart of the subject; initiating, in response to and during the detected episode of tachyarrhythmia, a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal, and deeming whether the ventricular tachyarrhythmia is stable according to the measurement of hemodynamic stability. The measurement of hemodynamic stability is determined using linear prediction.

摘要翻译： 一种方法包括使用可植入医疗装置（IMD）检测受试者中的至少一次心室快速性心律失常，使用IMD感测对象的至少一个心音信号，与心脏的心脏的机械振动相关的心音信号 学科; 响应于和在检测到的快速性心律失常发作期间，从心脏声音信号测量心室快速性心律失常的血液动力学稳定性，并且根据血液动力学稳定性的测量来确定心室性心律失常是否稳定。 使用线性预测确定血液动力学稳定性的测量。

公开(公告)号：US20110077541A1

公开(公告)日：2011-03-31

申请号：US12879147

申请日：2010-09-10

申请人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

发明人： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC分类号： A61B5/04

CPC分类号： A61B5/04525 ,  G06K9/00536

摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

摘要翻译： 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US07908001B2

公开(公告)日：2011-03-15

申请号：US11209976

申请日：2005-08-23

申请人： Dan Li ,  Yayun Lin

发明人： Dan Li ,  Yayun Lin

IPC分类号： A61N1/39

CPC分类号： A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

摘要翻译： 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。