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    Key switch device with low-profile key top which gives three-dimensional appearance and looks thicker than actual one
    21.
    发明授权
    Key switch device with low-profile key top which gives three-dimensional appearance and looks thicker than actual one 有权
    钥匙开关装置，具有低调的键顶，提供三维外观，看起来比实际更厚

    公开(公告)号：US06259049B1

    公开(公告)日：2001-07-10

    申请号：US09588445

    申请日：2000-06-06

    申请人： Takashi Nakai

    发明人： Takashi Nakai

    IPC分类号： H01H918

    CPC分类号： H01H13/705 ,  H01H2219/034

    摘要： A key switch device having a key top colored in a dark shade on the right and front side surfaces, in a light shade on the top surface, and in an intermediate shade between the color of the right and front side surfaces and the color of the top surface, on the left and rear side surfaces. Because of these different color shades, the right and front side surfaces look as if shaded; and the top surface presents a thick, three-dimensional appearance regardless of the direction of light falling thereon. That is, the key top, being low-profile, looks thick.

    摘要翻译： 一种钥匙开关装置，其具有在右侧和前侧表面上的黑色阴影中的顶部着色，顶表面上的光阴和在右侧表面和前侧表面的颜色之间的中间色调 顶表面，左侧和后侧表面。 由于这些不同的色调，右侧和前侧的表面看起来像阴影; 并且顶表面呈现厚而立体的外观，而与其上的光的方向无关。 也就是说，关键顶部，低调，看起来很厚。

    ANTIBODIES WITH MODIFIED AFFINITY TO FCRN THAT PROMOTE ANTIGEN CLEARANCE
    24.
    发明申请
    ANTIBODIES WITH MODIFIED AFFINITY TO FCRN THAT PROMOTE ANTIGEN CLEARANCE 审中-公开
    具有改良亲和力的抗体促进抗原清除

    公开(公告)号：US20130131319A1

    公开(公告)日：2013-05-23

    申请号：US13637415

    申请日：2011-03-30

    申请人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

    发明人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

    IPC分类号： C07K16/42

    CPC分类号： C07K16/283 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/70535 ,  C07K16/18 ,  C07K16/248 ,  C07K16/28 ,  C07K16/2866 ,  C07K16/4241 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

    摘要： An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies.

    摘要翻译： 本发明的目的是提供促进抗原结合分子介导的抗原向细胞摄取的方法，促进血浆中抗原浓度降低的方法，增加单一抗原结合分子所能抗原数目的方法 结合，用于改善抗原结合分子的药代动力学的方法，改进用于促进抗原摄入细胞的抗原结合分子，能够促进血浆中抗原浓度降低的抗原结合分子，能够重复结合抗原的抗原结合分子， 具有改善的药代动力学的抗原结合分子，包含这种抗原结合分子的药物组合物，以及用于制备上述那些的方法。 本发明人发现，通过在血浆pH下具有人FcRn结合活性的抗体和在早期内体体内的pH低于等离子体pH下抗原结合活性较低的抗体促进了对细胞的吸收; 这样的抗体可以增加单个抗体分子可以结合的抗原的数量; 可以通过施用这样的抗体来促进血浆中抗原的降低; 可以通过使用这样的抗体来改善抗体药代动力学。

    METHOD FOR FORMING COMPACT FROM POWDER AND SINTERED PRODUCT
    26.
    发明申请
    METHOD FOR FORMING COMPACT FROM POWDER AND SINTERED PRODUCT 有权
    从粉末和烧结产品形成紧密的方法

    公开(公告)号：US20100135841A1

    公开(公告)日：2010-06-03

    申请号：US12645198

    申请日：2009-12-22

    申请人： Takashi Nakai ,  Kinya Kawase

    发明人： Takashi Nakai ,  Kinya Kawase

    IPC分类号： B22F3/12 ,  B22F3/02 ,  B22F1/00 ,  C22C9/00 ,  C22C38/00

    CPC分类号： B22F3/02 ,  B22F2003/026 ,  B22F2003/145 ,  B30B15/0011

    摘要： A method for forming a compact from a powder wherein a forming portion 1A in a mold body 2 is filled with a raw powder and upper and lower punches 3,4 are fitted into the forming portion 1A to form the compact. Prior to filling the forming portion 1A with the raw powder M, a solution L with a lubricant being uniformly dissolved in a solvent is applied to a peripheral portion of the forming portion 1A, and then the solution is evaporated, thus forming a crystallized layer B thereon. Thus, the reduction of a force for ejecting the compact is realized, while improving the density of the compact, realizing the stable and successive production of the compact.

    摘要翻译： 一种从粉末形成压块的方法，其中模具体2中的成形部分1A填充有原料粉末，上冲头3,4和下冲头3,4装配到成形部分1A中以形成压块。 在用原料粉末M填充成形部1A之前，将具有均匀溶解在溶剂中的润滑剂的溶液L施加到成形部1A的周边部分，然后蒸发溶液，从而形成结晶化层B 上。 因此，在提高压实体的密度的同时，实现了用于压出压块的力的减小，实现了压块的稳定且连续的生产。

    Relay device for mobile device
    27.
    发明申请
    Relay device for mobile device 审中-公开
    移动设备的中继设备

    公开(公告)号：US20070184879A1

    公开(公告)日：2007-08-09

    申请号：US10557676

    申请日：2004-05-21

    申请人： Takashi Nakai

    发明人： Takashi Nakai

    IPC分类号： H04B1/38 ,  H04M1/00

    CPC分类号： H04M1/72527 ,  G06F1/1632 ,  H02J7/0044 ,  H04M1/04

    摘要： A relay device including print means that is value-added means is mounted to a mounting recessed portion of a battery charger, and a mobile phone that is a mobile device is mounted to a mounting recessed portion of the relay device. Thus electric power can be supplied to the secondary cell of the mobile phone and the print means of the relay device via the relay device from one battery charger. Characters and images displayed on a display of the mobile phone can be printed by the print means under the control from the mobile phone.

    摘要翻译： 包括作为增值装置的打印装置的中继装置被安装到电池充电器的安装凹部，并且作为移动装置的移动电话被安装到中继装置的安装凹部。 因此，能够从一个电池充电器经由中继装置向移动电话的二次电池和中继装置的打印装置供电。 显示在移动电话的显示器上的字符和图像可以由打印装置在手机的控制下打印。

    Powder molding die apparatus and method of molding for obtaining powder molding product
    29.
    发明申请
    Powder molding die apparatus and method of molding for obtaining powder molding product 有权
    粉末成型模具装置和用于获得粉末成型产品的模制方法

    公开(公告)号：US20060147570A1

    公开(公告)日：2006-07-06

    申请号：US10547047

    申请日：2004-03-26

    申请人： Takashi Nakai ,  Kinya Kawase

    发明人： Takashi Nakai ,  Kinya Kawase

    IPC分类号： B30B11/10

    CPC分类号： B22F3/03 ,  B22F2003/026 ,  B30B15/0011

    摘要： A surface treatment layer 11 is formed on a surface 10 of a through-hole 1 so that the surface 10 has an angle X of contact with solution L which is smaller than an angle Y of contact of a die 2 per se with the solution L. When the solution L is applied, the wetting action of the solution L relative to the through-hole 1 is improved so that the solution L can be extended over the surface treatment layer 11, eventually over the entire surface of the through-hole 1. Consequently, the entire surface thereof can be formed with a crystallized layer by performing water evaporation. As a result, molding at higher temperature can be realized, and high-density compacts can be stably obtained. Further, the solution L in which the lubricant is dissolved in a solvent into a homogeneous phase, is applied to a molding portion 1A, and then evaporated to thereby form crystals thereon, thus forming the crystallized layer.

    摘要翻译： 表面处理层11形成在通孔1的表面10上，使得表面10具有与溶液L接触的角度X，其小于模具2本身与溶液L的接触角度Y 当施加溶液L时，溶液L相对于通孔1的润湿作用被改善，使得溶液L可以最终在通孔1的整个表面上延伸到表面处理层11上 。 因此，其整个表面可以通过水蒸发形成结晶层。 结果，可以实现在较高温度下的成型，并且可以稳定地获得高密度压块。 此外，将其中将润滑剂溶解在溶剂中的溶液L施加到模制部分1A，然后蒸发，从而在其上形成晶体，从而形成结晶层。

    Multi-directional pressure-responsive input device
    30.
    发明授权
    Multi-directional pressure-responsive input device 有权
    多向压力响应输入装置

    公开(公告)号：US06977644B2

    公开(公告)日：2005-12-20

    申请号：US10355888

    申请日：2003-01-31

    申请人： Yoshihisa Endo ,  Takashi Nakai

    发明人： Yoshihisa Endo ,  Takashi Nakai

    IPC分类号： G06F3/02 ,  G06F3/033 ,  G06F3/038 ,  H01H13/702 ,  H01H13/712 ,  H01H13/785 ,  G09G5/08 ,  A63F13/00 ,  H03K17/94

    CPC分类号： G06F3/0338 ,  H01H13/702 ,  H01H13/785 ,  H01H2201/036 ,  H01H2221/012 ,  H01H2239/078 ,  H01H2300/022

    摘要： The input device of the invention includes: a lower sheet on which four resistors are formed in a manner that each two of them with a center put in between are placed to face each other circumferentially with a spacing of about 90°; an upper sheet overlying the lower sheet with a spacing, on which conductors are formed to face the respective resistors; elastic bodies disposed over the upper sheet to face the respective conductors; and an operation member to retain upper parts of the elastic bodies. And, when the operation member is pressed downward, the elastic bodies are brought into contact with the resistors with interventions of the conductors on the upper sheet.

    摘要翻译： 本发明的输入装置包括：下片，其上形成有四个电阻器，其中每个两个具有中心的两个电极被放置成以约90°的间隔圆周地彼此面对; 上片以间隔覆盖下片，导体形成在其上面对各个电阻器; 弹性体设置在上片上以面对各个导体; 以及用于保持弹性体的上部的操作构件。 并且，当操作构件向下压时，弹性体通过导体在上片上的干预而与电阻器接触。