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    Implantable infusion device and reservoir for same
    24.
    发明授权
    Implantable infusion device and reservoir for same 有权
    植入式输液装置和储罐相同

    公开(公告)号：US06652510B2

    公开(公告)日：2003-11-25

    申请号：US10033377

    申请日：2001-12-26

    申请人： Peter C. Lord ,  William A. Brandt ,  Scott R. Gibson

    发明人： Peter C. Lord ,  William A. Brandt ,  Scott R. Gibson

    IPC分类号： A61K922

    CPC分类号： A61M5/14276 ,  A61M5/14224 ,  A61M5/14244 ,  A61M5/14586 ,  Y10S128/12

    摘要： An implantable infusion device includes of a disc-shaped housing that is made from a biocompatible material and contains a reservoir. The reservoir defines a chamber that contains at least one flexible diaphragm. A ring is provided in alignment with the peripheral edge of each diaphragm. The ring has a central opening that is aligned with the convolution and central portion of each diaphragm, to allow the diaphragm to flex within the ring. In this manner, the volume on one side of each diaphragm may be varied to correspond to a varying volume of infusion medium. Similarly, the volume within the reservoir chamber on the other side of the diaphragms is varied as the diaphragms flex, to correspond to the expansion and contraction of a propellant medium within the reservoir.

    摘要翻译： 植入式输注装置包括由生物相容性材料制成且包含储存器的圆盘形壳体。 储存器限定包含至少一个柔性隔膜的室。 提供与每个隔膜的周缘对准的环。 环具有与每个隔膜的卷积和中心部分对准的中心开口，以允许隔膜在环内弯曲。 以这种方式，每个隔膜的一侧上的体积可以变化以对应于输注介质的变化体积。 类似地，当膜片弯曲时，膜片另一侧的储存室内的体积随着储存器内的推进剂介质的膨胀和收缩而变化。

    Optical glucose sensor
    25.
    发明授权
    Optical glucose sensor 失效
    光学葡萄糖传感器

    公开(公告)号：US5605152A

    公开(公告)日：1997-02-25

    申请号：US276453

    申请日：1994-07-18

    申请人： John B. Slate ,  Peter C. Lord

    发明人： John B. Slate ,  Peter C. Lord

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  C12Q1/00 ,  G01N21/77 ,  G02B6/00

    CPC分类号： A61B5/1459 ,  A61B5/14532 ,  C12Q1/006 ,  G01N21/7703 ,  G01N2021/772 ,  G01N2021/7759 ,  G01N2021/7786

    摘要： An improved glucose sensor adapted for in vivo implantation includes one or more optical fiber optrodes mounted within a semipermeable probe housing designed for differential diffusion of glucose and oxygen. In a preferred form, an enzyme optrode comprises an optical fiber with an enzyme coating such as glucose oxidase for catalyzing glucose in the presence of oxygen (O.sub.2) to produce gluconic acid and hydrogen peroxide. An oxygen sensitive coating such as a fluorescent dye is provided on the enzyme optrode in close proximity with the enzymatic reaction, and also on a reference optrode at a position spaced substantially from the enzymatic reaction. Optical monitoring of the fluorescent activity of the optrode coatings provides an indication of oxygen depletion as a result of the enzymatic reaction, and thus also indicates glucose concentration level. The semipermeable housing is designed to ensure that the reaction proceeds with a stoichiometric excess of oxygen (O.sub.2).

    摘要翻译： 适于体内植入的改进的葡萄糖传感器包括一个或多个光纤光栅，其安装在设计用于葡萄糖和氧的差分扩散的半透性探针壳体内。 在优选的形式中，酶极性包括具有酶包衣如葡萄糖氧化酶的光纤，用于在氧气（O 2）存在下催化葡萄糖以产生葡萄糖酸和过氧化氢。 在酶反应附近提供氧敏感性涂层如荧光染料，邻近于酶反应，并且还与基本上与酶反应间隔的位置处的参考光学反应。 对光学涂层的荧光活性的光学监测提供了由于酶反应而导致的氧耗竭的指示，因此也表明葡萄糖浓度水平。 半透性外壳设计用于确保反应以化学计量过量的氧（O 2）进行。

    Closed loop infusion pump system with removable glucose sensor
    26.
    发明授权
    Closed loop infusion pump system with removable glucose sensor 失效
    具有可移除葡萄糖传感器的闭环输液泵系统

    公开(公告)号：US5569186A

    公开(公告)日：1996-10-29

    申请号：US231800

    申请日：1994-04-25

    申请人： Peter C. Lord ,  Fredric C. Coleman

    发明人： Peter C. Lord ,  Fredric C. Coleman

    IPC分类号： A61B5/00 ,  A61M5/172 ,  A61M31/00

    CPC分类号： A61B5/6865 ,  A61B5/0002 ,  A61B5/14532 ,  A61M5/1723

    摘要： An infusion pump system includes a removable in vivo glucose sensor for monitoring glucose concentration level in a patient, and for signaling an infusion pump to deliver a selected medication such as insulin to a patient. The glucose sensor comprises a sensor cable for placement through a catheter to position a distal sensor tip at a selected in vivo sensor site. A proximal end of the sensor cable seats within a connector fitting mounted on the catheter at a convenient and accessible subcutaneous position. The connector fitting couples the sensor cable to an implanted control unit which signals the infusion pump to deliver the patient medication. In a preferred system, the infusion pump is also implanted and receives control signals via a direct or telemetric connection. The sensor cable is easily accessed at the connector fitting for periodic sensor removal and replacement, without requiring removal or replacement of other system components.

    摘要翻译： 输液泵系统包括可移除的体内葡萄糖传感器，用于监测患者的葡萄糖浓度水平，以及用于发信号通知输液泵将选定的药物如胰岛素递送给患者。 葡萄糖传感器包括用于通过导管放置以将远侧传感器尖端定位在所选择的体内传感器位置的传感器电缆。 传感器电缆的近端位于安装在导管上的方便和可及的皮下位置的连接器配件内。 连接器配件将传感器电缆耦合到植入的控制单元，其传送输液泵以输送患者药物。 在优选的系统中，输注泵也被植入并经由直接或遥测连接接收控制信号。 传感器电缆可轻松访问连接器配件，以便定期进行传感器拆卸和更换，无需拆卸或更换其他系统组件。

    Transcutaneous sensor insertion set
    27.
    发明授权
    Transcutaneous sensor insertion set 失效
    经皮传感器插入组

    公开(公告)号：US5568806A

    公开(公告)日：1996-10-29

    申请号：US393159

    申请日：1995-02-16

    申请人： Paul S. Cheney, II ,  John J. Mastrototaro ,  Nannette M. Schnabel ,  Peter C. Lord ,  William P. Van Antwerp ,  Raymond D. Clark

    发明人： Paul S. Cheney, II ,  John J. Mastrototaro ,  Nannette M. Schnabel ,  Peter C. Lord ,  William P. Van Antwerp ,  Raymond D. Clark

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486 ,  A61B17/34

    CPC分类号： A61B5/4839 ,  A61B17/3403 ,  A61B5/14532 ,  A61B5/6849

    摘要： An improved insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises an insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and adapted for electrical connection to a suitable monitor or the like, and a distal segment protruding from the mounting base with sensor electrodes thereon for transcutaneous placement. The distal segment of the sensor and a distal segment of the insertion needle are positioned within a flexible cannula which extends from the mounting base, whereby placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn from the cannula and the mounting base to leave the sensor distal segment at the selected insertion position, with the sensor electrodes being exposed to patient blood or other extracellular fluid via a window formed in the cannula. The cannula is carried by the mounting base to insure alignment of the sensor electrodes with the cannula window.

    摘要翻译： 提供了一种改进的插入组，用于在患者体内的选定位置处经皮放置诸如葡萄糖传感器的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的插入针。 柔性薄膜传感器包括由安装基座承载并适于与合适的监视器等电连接的近端段，以及从安装基座突出并具有用于经皮放置的传感器电极的远端段。 传感器的远端部分和插入针的远侧部分定位在从安装基部延伸的柔性套管内，由此将安装基座放置在患者皮肤上使得插入针刺穿皮肤以经皮放置 套管与传感器在其中。 然后可以将插入针从插管和安装基座中取出，以将传感器远端段离开所选择的插入位置，传感器电极通过形成在套管中的窗口暴露于患者血液或其它细胞外液体。 套管由安装基座承载，以确保传感器电极与套管窗口的对准。

    Medication infusion pump with improved liquid-vapor pressure reservoir
    28.
    发明授权
    Medication infusion pump with improved liquid-vapor pressure reservoir 失效
    药液输液泵具有改进的液 - 气压储层

    公开(公告)号：US5176644A

    公开(公告)日：1993-01-05

    申请号：US619859

    申请日：1990-11-29

    申请人： Chad Srisathapat ,  Peter C. Lord

    发明人： Chad Srisathapat ,  Peter C. Lord

    IPC分类号： A61M5/142

    CPC分类号： A61M5/14276 ,  Y10S128/12

    摘要： An implantable medication infusion pump is provided which utilizes an improved and simplified pressure reservoir to maintain a selected medication in liquid form within a pump housing under a substantially constant pressure. The pressure reservoir comprises a hollow structural enclosure having at least one flexible resilient wall and is adapted to be filled with a selected quantity of a pressure fluid, such as a selected fluorocarbon in a liquid-vapor state, prior to mounting of the reservoir as a structural unit into the infusion pump housing. Within the pump housing, the flexible reservoir wall defines one side of a medication chamber, with the pressure fluid undergoing appropriate change of state to expand or contract the reservoir in a manner maintaining the medication under a substantially constant pressure. The improved reservoir can be provided in a variety of structural shapes and/or utilized in pump housings of various size and shape to permit the pump size to be reduced, or, in the alternative, to increase pump medication capacity without increasing pump housing size.

    摘要翻译： 提供了一种可植入药物输注泵，其利用改进和简化的压力储存器，以在基本恒定的压力下在泵壳体内将选定的液体形式的药物保持在液体形式中。 压力储存器包括具有至少一个柔性弹性壁的中空结构外壳，并且适于在将储存器安装为液体蒸气状态之前填充选定量的压力流体，例如所选择的液体 - 气体状态的碳氟化合物 结构单元进入输液泵壳体。 在泵壳体内，柔性储存器壁限定药物室的一侧，其中压力流体经历适当的状态改变，以将药物保持在基本上恒定的压力下，以使储存器膨胀或收缩。 改进的储存器可以以各种结构形状提供和/或用于各种尺寸和形状的泵壳体中，以允许减小泵的尺寸，或者替代地，在不增加泵壳体尺寸的情况下提高泵的药用能力。

    Liquid-vapor pressure reservoir for medication infusion pump
    29.
    发明授权
    Liquid-vapor pressure reservoir for medication infusion pump 失效
    用于药物灌注泵的液体蒸汽压力储存器

    公开(公告)号：US5167633A

    公开(公告)日：1992-12-01

    申请号：US619650

    申请日：1990-11-29

    申请人： Alfred E. Mann ,  Peter C. Lord

    发明人： Alfred E. Mann ,  Peter C. Lord

    IPC分类号： A61M5/00 ,  A61M1/36 ,  A61M5/142 ,  A61M37/00

    CPC分类号： A61M5/14276 ,  Y10S128/12

    摘要： An improved and simplified pressure reservoir is provided for use with an implantable medication infusion pump to maintain a selected medication in liquid form with a pump housing under a substantially constant pressure. The pressure reservoir comprises a hollow structural enclousre having at least one flexible resilient wall and is adapted to be filled with a selected quantity of a pressure fluid, such as a selected fluorocarbon in a liquid-vapor state, prior to mounting of the reservoir as a structural unit into the infusion pump housing. Within the pump housing, the flexible reservoir wall defines one side of a medication chamber, with the pressure fluid undergoing appropriate change of state to expand or contact the reservoir in a manner maintaining the medication under a substantially constant pressure. The improved reservoir can be provided in a variety of structural shapes and/or utilized in pump housings of various size and shape to permit the pump size to be reduced, or, in the alternative, to increase pump medication capacity without increasing pump housing size.

    Soft cannula subcutaneous injection set
    30.
    发明授权
    Soft cannula subcutaneous injection set 失效
    软套管皮下注射套装

    公开(公告)号：US4755173A

    公开(公告)日：1988-07-05

    申请号：US58067

    申请日：1987-06-04

    申请人： April A. Konopka ,  Peter C. Lord

    发明人： April A. Konopka ,  Peter C. Lord

    IPC分类号： A61M5/158 ,  A61M25/06 ,  A61M39/04 ,  A61M5/00

    CPC分类号： A61M25/0606 ,  A61M39/04 ,  A61M2005/1581 ,  A61M2039/0054 ,  A61M2039/0072 ,  A61M2205/197 ,  Y10S128/26

    摘要： An injection set for delivering a fluid to a subcutaneous injection location in a patient is disclosed which has a soft cannula projecting from a bottom surface of a holding pad. An insertion needle is initially inserted through a septum located between a catheter hub and a retaining cap mounted on the holding pad. The insertion needle extends through a fluid chamber defined by the septum and the catheter hub and then through a lumen of the soft cannula, with the sharpened tip of the insertion needle extending beyond the end of the soft cannula when the insertion needle is fully inserted. The insertion needle, which allows priming of the injection set, may be removed following installation of the injection set without kinking of the soft catheter, and fluid may be supplied to the injection set for delivery to the patient.

    摘要翻译： 公开了一种用于将流体输送到患者的皮下注射位置的注射器，其具有从保持垫的底表面突出的软套管。 插入针最初穿过位于导管毂和安装在保持垫上的保持盖之间的隔膜。 插入针延伸穿过由隔膜和导管套筒限定的流体室，然后穿过软插管的内腔，当插入针完全插入时，插入针的尖锐尖端延伸超过软插管的端部。 可以在安装注射装置之后移除注射装置的注射针头，而不会扭曲软导管，并且可将流体供应到注射装置以递送给患者。