利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.038 秒)

    Transcutaneous sensor insertion set
    1.
    发明授权
    Transcutaneous sensor insertion set 失效
    经皮传感器插入组

    公开(公告)号：US5568806A

    公开(公告)日：1996-10-29

    申请号：US393159

    申请日：1995-02-16

    申请人： Paul S. Cheney, II ,  John J. Mastrototaro ,  Nannette M. Schnabel ,  Peter C. Lord ,  William P. Van Antwerp ,  Raymond D. Clark

    发明人： Paul S. Cheney, II ,  John J. Mastrototaro ,  Nannette M. Schnabel ,  Peter C. Lord ,  William P. Van Antwerp ,  Raymond D. Clark

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486 ,  A61B17/34

    CPC分类号： A61B5/4839 ,  A61B17/3403 ,  A61B5/14532 ,  A61B5/6849

    摘要： An improved insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises an insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and adapted for electrical connection to a suitable monitor or the like, and a distal segment protruding from the mounting base with sensor electrodes thereon for transcutaneous placement. The distal segment of the sensor and a distal segment of the insertion needle are positioned within a flexible cannula which extends from the mounting base, whereby placement of the mounting base onto the patient's skin causes the insertion needle to pierce the skin for transcutaneous placement of the cannula with the sensor therein. The insertion needle can then be withdrawn from the cannula and the mounting base to leave the sensor distal segment at the selected insertion position, with the sensor electrodes being exposed to patient blood or other extracellular fluid via a window formed in the cannula. The cannula is carried by the mounting base to insure alignment of the sensor electrodes with the cannula window.

    摘要翻译： 提供了一种改进的插入组，用于在患者体内的选定位置处经皮放置诸如葡萄糖传感器的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的插入针。 柔性薄膜传感器包括由安装基座承载并适于与合适的监视器等电连接的近端段，以及从安装基座突出并具有用于经皮放置的传感器电极的远端段。 传感器的远端部分和插入针的远侧部分定位在从安装基部延伸的柔性套管内，由此将安装基座放置在患者皮肤上使得插入针刺穿皮肤以经皮放置 套管与传感器在其中。 然后可以将插入针从插管和安装基座中取出，以将传感器远端段离开所选择的插入位置，传感器电极通过形成在套管中的窗口暴露于患者血液或其它细胞外液体。 套管由安装基座承载，以确保传感器电极与套管窗口的对准。

    Transcutaneous sensor insertion set
    2.
    发明授权
    Transcutaneous sensor insertion set 失效
    经皮传感器插入组

    公开(公告)号：US5390671A

    公开(公告)日：1995-02-21

    申请号：US213101

    申请日：1994-03-15

    申请人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    发明人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    IPC分类号： G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B17/34 ,  A61M25/02 ,  G01N27/28 ,  G01N33/49 ,  A61B5/05 ,  A61B5/04

    CPC分类号： A61B5/14865 ,  A61B17/3403 ,  A61B5/6849 ,  A61M25/02 ,  A61M2025/0206

    摘要： An insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises a slotted insertion needle extending through a mounting base adapted for mounting onto the patient's skin. A flexible thin film sensor includes a proximal segment carried by the mounting base and defining conductive contacts adapted for electrical connection to a suitable monitor, and a distal segment protruding from the mounting base with sensor electrodes for transcutaneous placement. The proximal and distal segments of the sensor are linearly offset or misaligned, with the distal segment fitted within the insertion needle for transcutaneous sensor placement with the needle as the mounting base is pressed onto the patient's skin. The insertion needle can then be withdrawn to leave the sensor distal segment at the selected insertion position with the sensor electrodes in contact with patient blood or other extracellular fluid.

    摘要翻译： 提供插入组用于在病人体内的选定部位经皮放置诸如葡萄糖传感器之类的传感器。 插入组包括延伸穿过适于安装到患者皮肤上的安装基座的开槽插入针。 柔性薄膜传感器包括由安装基座承载的近端段，并且限定适于与合适的监视器电连接的导电触头，以及从安装基座突出的用于经皮放置的传感器电极的远端段。 传感器的近端段和远端段线性偏移或不对准，远端段装配在插入针内，用于经皮传感器放置，随着安装基座被压在病人的皮肤上。 然后可以将插入针抽出以将传感器远端段离开所选择的插入位置，同时传感器电极与患者血液或其它细胞外液接触。

    Flex circuit connector
    3.
    发明授权
    Flex circuit connector 失效
    Flex电路连接器

    公开(公告)号：US5482473A

    公开(公告)日：1996-01-09

    申请号：US239960

    申请日：1994-05-09

    申请人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    发明人： Peter C. Lord ,  William P. Van Antwerp ,  John J. Mastrototaro ,  Paul S. Cheney, II ,  Nannette M. Schnabel

    IPC分类号： H01R12/77 ,  H01R12/78 ,  H01R12/88 ,  H05K3/32 ,  H05K3/36 ,  H01R9/09

    CPC分类号： H01R12/774 ,  H01R12/78 ,  H01R12/88 ,  A61B2562/227 ,  H05K2201/0133 ,  H05K3/325 ,  H05K3/361 ,  H05K3/365

    摘要： A connector is provided for electrical connection to a flex circuit in a hermetically sealed manner. The flex circuit comprises thin film conductors encased between layers of insulative material, and including a proximal end with conductive contact pads exposed through one of the insulative layers. In a preferred form, the proximal ends of the two flex circuits are assembled in face-to-face relation and compressed by a clamp fixture against opposite side faces of a compressible terminal block. The terminal block is formed from a resilient insulative elastomer such as silicone rubber with embedded conductive strips having opposite edges exposed at the opposite side faces of the terminal block for electrically connecting aligned pairs of the contact pads on the two flex circuits. The exposed edges of the conductive strips are circumscribed by the insulative elastomer which engages the flex circuits with a footprint circumscribing the exposed contact pads, whereby the terminal block hermetically seals the interface between the conductive strips and the contact pads.

    摘要翻译： 提供了一种用于以气密密封的方式电连接到柔性电路的连接器。 柔性电路包括封装在绝缘材料层之间的薄膜导体，并且包括具有通过绝缘层之一暴露的导电接触焊盘的近端。 在优选形式中，两个柔性电路的近端以面对面关系组装，并通过夹具固定器压靠在可压缩端子块的相对侧面上。 端子块由诸如硅橡胶的弹性绝缘弹性体形成，其中嵌入的导电带具有暴露在端子块的相对侧面处的相对边缘，用于电连接两个柔性电路上的对准的接触焊盘对。 导电条的暴露边缘由绝缘弹性体外接，该绝缘弹性体与柔性电路接合，其外接外露的接触焊盘，从而端子块气密地密封导电条和接触焊盘之间的界面。

    Method of fabricating thin film sensors
    4.
    发明授权
    Method of fabricating thin film sensors 失效
    制造薄膜传感器的方法

    公开(公告)号：US5391250A

    公开(公告)日：1995-02-21

    申请号：US212961

    申请日：1994-03-15

    申请人： Paul S. Cheney, II ,  William P. Van Antwerp

    发明人： Paul S. Cheney, II ,  William P. Van Antwerp

    IPC分类号： G01N33/50 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1477 ,  A61B5/1486 ,  B32B38/10 ,  G01N27/28 ,  G01N27/403 ,  B29C65/00 ,  B32B31/00

    CPC分类号： B32B38/10 ,  G01N27/3272 ,  B32B2310/0843 ,  B32B2457/00 ,  Y10T156/1082

    摘要： An improved method is provided for making thin film electrochemical sensors, such as subcutaneous glucose sensors used to monitor blood glucose levels in a diabetic patient. The fabrication method comprises placing a thin film base layer of insulative material onto a rigid flat substrate, with a curable adhesive interposed between the perimeter of the base layer and substrate to define a shallow cavity underlying a central portion of the base layer. The subassembly is subjected to heat and pressure to cure the adhesive, resulting in air expulsion from the cavity such that the central portion of the base layer is drawn into intimate contact with the substrate. Appropriate conductor elements for one or more sensors are formed on the base layer as by conventional contact mask photolithography, and a thin film cover layer of insulative material is applied thereover with apertures in the cover layer exposing distal end sensor electrodes and proximal end contact pads. The insulative cover and base layers are then cut along a line surrounding each finished sensor which is lifted and separated easily from the substrate.

    摘要翻译： 提供了一种改进的方法来制造薄膜电化学传感器，例如用于监测糖尿病患者血糖水平的皮下葡萄糖传感器。 该制造方法包括将绝缘材料的薄膜基底层放置在刚性平坦基底上，其中可固化粘合剂插入在基底层的周边和基底之间，以限定在基底层的中心部分下面的浅腔。 将该组件经受热和压力以使粘合剂固化，导致空气从空腔排出，使得基层的中心部分被拉伸成与基底紧密接触。 通过常规的接触掩模光刻法，在基底层上形成用于一个或多个传感器的适当的导体元件，并且在其上施加绝缘材料的薄膜覆盖层，覆盖层中的孔露出远端传感器电极和近端接触焊盘。 然后，沿着围绕每个成品传感器的线切割绝缘盖和基层，所述传感器被提起并容易地从基板分离。

    Analyte sensor method of making the same
    6.
    发明授权
    Analyte sensor method of making the same 有权
    分析物传感器的制作方法

    公开(公告)号：US07003336B2

    公开(公告)日：2006-02-21

    申请号：US09779282

    申请日：2001-02-08

    申请人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp ,  Nannette Van Antwerp

    发明人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp ,  Nannette Van Antwerp

    IPC分类号： B65D85/38 ,  A61B5/05 ,  A61B5/04

    CPC分类号： A61B5/14865 ,  A61B5/6849 ,  A61M2005/1726

    摘要： A sensor and method of making the same for implantation in a body that includes a substrate with notches cut in the substrate to form a necked down region in the substrate; and at least one sensor electrode formed from one or more conductive layers. Preferably, the thickness of the substrate ranges from approximately 25μ to 350μ, but the thickness of the substrate can range from 5μ to 750μ. The sensor may be incorporated in to a sensor assembly includes a slotted needle having a slot. The notches creating the necked down region allow the substrate to slide into the slotted needle, which that has the slot narrow enough to permit passage of the necked down region. However, a non-necked down region of the substrate is prevented from pulling out of the slotted needle through the slot. The slot of the slotted needle may also permit the necked down region of the substrate to slide down the slot.

    摘要翻译： 一种传感器及其制造方法，用于植入体内，其包括在衬底中切口切口的衬底，以在衬底中形成颈缩区域; 以及由一个或多个导电层形成的至少一个传感器电极。 优选地，基板的厚度范围为约25μm至350μm，但基板的厚度可以在5μm至750μm的范围内。 传感器可以结合到传感器组件中，包括具有槽的开槽针。 产生颈缩区域的切口允许基底滑入开槽针，其具有足够窄的狭槽以允许颈缩区域的通过。 然而，防止了衬底的非颈缩区域从槽缝拉出。 开槽针的槽还可以允许衬底的颈缩区域沿着槽滑下来。

    Analyte sensor and method of making the same
    7.
    发明授权
    Analyte sensor and method of making the same 有权
    分析物传感器及其制作方法

    公开(公告)号：US06484045B1

    公开(公告)日：2002-11-19

    申请号：US09502204

    申请日：2000-02-10

    申请人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp

    发明人： James D. Holker ,  Guillermo A. Calle ,  Kevin D. Branch ,  John J. Mastrototaro ,  William P. Van Antwerp

    IPC分类号： A61B505

    CPC分类号： A61B5/14865

    摘要： A method of making a sensor includes the steps of providing a preformed self-supporting flexible substrate; sputter-depositing a metal layer on the substrate; etching the sputter-deposited metal layers to form a sensor electrode having a proximal segment and a distal segment; plating a metal layer on the sensor electrode; and separating the sensor electrode and at least a portion of the substrate underlying the sensor electrode from the remainder of the substrate. Sensors prepared according to the inventive methods, and sensor sets including the sensors, are also provided.

    摘要翻译： 制造传感器的方法包括以下步骤：提供预制的自支撑柔性基板; 在衬底上溅射沉积金属层; 蚀刻溅射沉积的金属层以形成具有近端段和远端段的传感器电极; 在传感器电极上镀金属层; 以及将所述传感器电极和所述传感器电极下方的所述衬底的至少一部分与所述衬底的其余部分分开。 还提供了根据本发明方法制备的传感器，以及包括传感器的传感器组。

    Closed loop system for controlling insulin infusion
    10.
    发明授权
    Closed loop system for controlling insulin infusion 有权
    用于控制胰岛素输注的闭环系​​统

    公开(公告)号：US06558351B1

    公开(公告)日：2003-05-06

    申请号：US09586175

    申请日：2000-06-01

    申请人： Garry M. Steil ,  Kerstin Rebrin ,  Paul V. Goode, Jr. ,  John J. Mastrototaro ,  Richard E. Purvis ,  William P. Van Antwerp ,  John J. Shin ,  Cary D. Talbot

    发明人： Garry M. Steil ,  Kerstin Rebrin ,  Paul V. Goode, Jr. ,  John J. Mastrototaro ,  Richard E. Purvis ,  William P. Van Antwerp ,  John J. Shin ,  Cary D. Talbot

    IPC分类号： A61M3700

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7242 ,  A61M5/14244 ,  A61M5/158 ,  A61M5/1582 ,  A61M5/1723 ,  A61M2005/1581 ,  A61M2005/1726 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

    摘要： A closed loop infusion system controls the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The sensor signal is used to generate a controller input. The controller uses the controller input to generate commands to operate the delivery system. The delivery system infuses a liquid into the user at a rate dictated by the commands from the controller. Preferably, the sensor system monitors the glucose concentration in the body of the user, and the liquid infused by the delivery system into the body of the user includes insulin. The sensor system uses the sensor signal to generate a message that is sent to the delivery system. The message includes the information used to generate the controller input. The sensor may be a subcutaneous sensor in contact with interstitial fluid. Also, two or more sensors may be used by the sensor system.

    摘要翻译： 闭环输注系统控制流体注入使用者身体的速度。 闭环输注系统包括传感器系统，控制器和输送系统。 传感器系统包括用于监测用户状况的传感器。 传感器产生一个传感器信号，代表用户的状态。 传感器信号用于生成控制器输入。 控制器使用控制器输入来生成操作传送系统的命令。 输送系统以由控制器的命令指示的速率将液体注入用户。 优选地，传感器系统监测用户体内的葡萄糖浓度，并且由输送系统输入到使用者体内的液体包括胰岛素。 传感器系统使用传感器信号来产生发送到传送系统的消息。 该消息包括用于生成控制器输入的信息。 传感器可以是与间质液接触的皮下传感器。 此外，传感器系统可以使用两个或更多个传感器。