Biodegradable drug delivery material for stent

    公开(公告)号:US07470283B2

    公开(公告)日:2008-12-30

    申请号:US10340157

    申请日:2003-01-10

    申请人: Debashis Dutta

    发明人: Debashis Dutta

    IPC分类号: A61F2/06

    CPC分类号: A61F2/86 A61F2250/0067

    摘要: A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.

    Lubricious catheter shaft
    23.
    发明授权
    Lubricious catheter shaft 有权
    润滑导管轴

    公开(公告)号:US06589464B1

    公开(公告)日:2003-07-08

    申请号:US09656497

    申请日:2000-09-07

    申请人: Debashis Dutta

    发明人: Debashis Dutta

    IPC分类号: B29C4700

    摘要: An intravascular catheter which has a lubricious catheter shaft formed from a polymeric blend comprising a thermoplastic polymeric component and a lubricious polymeric component. The lubricious polymeric component is immiscible in the thermoplastic polymeric component and exists as elongated fibers having a high aspect ratio. The lubricious component exists as a separate phase of elongated fibers which provide improved lubricity to an extruded catheter shaft formed of the polymeric blend of the invention. The aspect ratio of the lubricious component fibers is about 10 to about 100, and preferably at least about 20. The high aspect ratio of the lubricious component fibers increase the surface area of the lubricious component on the surface of the catheter shaft, and consequently increase the lubricity of the catheter shaft.

    摘要翻译: 一种血管内导管,其具有由包含热塑性聚合物组分和润滑聚合物组分的聚合物共混物形成的润滑导管轴。 光滑聚合物组分在热塑性聚合物组分中是不混溶的,并以具有高纵横比的细长纤维存在。 润滑组分作为细长纤维的单独相存在,其为由本发明的聚合物共混物形成的挤出导管轴提供改进的润滑性。 光滑组分纤维的纵横比为约10至约100,优选至少约20.光滑组分纤维的高纵横比增加导管轴表面上的润滑组分的表面积,因此增加 导管轴的润滑性。

    Expandable stent dimensional retention system and method
    24.
    发明授权
    Expandable stent dimensional retention system and method 有权
    可扩展支架尺寸保持系统和方法

    公开(公告)号:US06506202B1

    公开(公告)日:2003-01-14

    申请号:US09612855

    申请日:2000-07-10

    IPC分类号: A61M2900

    摘要: A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of treating an entire affected area in a blood vessel while preventing adverse effects for healthy tissue. The system includes a catheter which is positionable in a blood vessel at the interventional procedure site. The system further includes an expandable interventional instrument such as an expandable stent which is expandable and which may be deployed in the blood vessel at the interventional procedure site, which includes an unexpanded axial dimension. The system also includes an expandable member such as an expandable balloon, for expanding the expandable stent. The expandable balloon is capable of expanding so as to expand and deploy the expandable stent, and to substantially retain the unexpanded axial dimension of the expandable stent. The expansion of the expandable balloon prevents lengthening or shortening of the expandable stent, so as to enable the entire affected lesion area to be covered precisely without affecting the surrounding healthy tissue upon deployment of the expandable stent.

    摘要翻译: 当在狭窄或闭塞的区域进行介入手术时在血管中使用的系统,其能够治疗血管中的整个受影响区域,同时防止对健康组织的不利影响。 该系统包括可在介入手术部位的血管中定位的导管。 该系统还包括可扩张的介入器械,例如可扩张的支架,其是可扩张的并且可以在包括未膨胀的轴向尺寸的介入手术部位的血管中展开。 该系统还包括可膨胀构件,例如可膨胀气囊,用于扩张可扩张支架。 可膨胀气囊能够膨胀以扩张和展开可扩张支架,并且基本上保持可扩张支架的未膨胀的轴向尺寸。 可膨胀气囊的膨胀防止了可扩张支架的延长或缩短,从而使整个受影响的损伤区域能够精确地覆盖,而不会在展开支架时展开周围的健康组织。

    Biodegradable polymers for use with implantable medical devices
    28.
    发明授权
    Biodegradable polymers for use with implantable medical devices 有权
    用于可植入医疗器械的可生物降解聚合物

    公开(公告)号:US07875283B2

    公开(公告)日:2011-01-25

    申请号:US11155036

    申请日:2005-06-16

    IPC分类号: A61F2/00

    CPC分类号: A61F2/82 A61F2210/0004

    摘要: The present invention relates to a stent fabricated of or coated with a composition comprising a biodegradable hydrophobic polymer containing water-labile bonds such that a device fabricated of the composition or the surface of a device coated with the requisite mechanical characteristics required of a stent and the polymer erodes from its outer surface inward.

    摘要翻译: 本发明涉及一种由含有水不稳定键的可生物降解的疏水性聚合物的组合物制成或涂覆的支架,使得由组合物制造的装置或涂覆有支架所需的必要机械特性的装置的表面和 聚合物从其外表面向内侵蚀。

    Nanoporous Silicate Membranes for Portable Fuel
    29.
    发明申请
    Nanoporous Silicate Membranes for Portable Fuel 审中-公开
    用于便携式燃料的纳米多孔硅酸盐膜

    公开(公告)号:US20110014546A1

    公开(公告)日:2011-01-20

    申请号:US12670921

    申请日:2008-07-28

    申请人: Debashis Dutta

    发明人: Debashis Dutta

    IPC分类号: H01M8/04

    摘要: A fuel cell is disclosed which has a significantly reduced internal resistance and which can be miniaturized. Two substrates are prepared, on with microchannels running along its facing surface and the other with nanochannels running along its facing surface. A silica-based binder is used to bind the substrates together with the microchannels running orthogonal to the nanochannels. The binder is removed from the microchannels and a fuel is introduced into at least one of the microchannels and an oxidant is introduced into at least one other of the microchannels.

    摘要翻译: 公开了具有显着降低的内阻并且可以小型化的燃料电池。 准备两个基板,微通道沿着其相对表面运行,另一个具有沿其相对表面延伸的纳米通道。 使用二氧化硅基粘合剂将衬底与正交于纳米通道的微通道结合在一起。 将粘合剂从微通道中除去,并将燃料引入到至少一个微通道中,并且将氧化剂引入至少另一个微通道中。

    Inflatable member formed of liquid crystal polymeric material blend

    公开(公告)号:US06596219B2

    公开(公告)日:2003-07-22

    申请号:US09970817

    申请日:2001-10-03

    IPC分类号: B29D2300

    摘要: A catheter having an inflatable member formed of a liquid crystal polymeric material. The inflatable member is formed from a blend of a minor amount, preferably less than 10%, of liquid crystal polymer with a major amount of a non-liquid crystal polymer having LCP fibers that are highly oriented in the machine direction. The aspect ratio of the liquid crystal polymeric material fibers is greater than 10, so that the polymer blend has mechanical characteristics similar to a fiber-reinforced composite with improved strength and optimal compliance.