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    Methods and compositions for detection of biological materials using microfluidic devices
    1.
    发明授权
    Methods and compositions for detection of biological materials using microfluidic devices 有权
    使用微流体装置检测生物材料的方法和组合物

    公开(公告)号：US08507208B2

    公开(公告)日：2013-08-13

    申请号：US12842526

    申请日：2010-07-23

    申请人： Robert C. Corcoran ,  Debashis Dutta

    发明人： Robert C. Corcoran ,  Debashis Dutta

    IPC分类号： G01N33/53 ,  G01N33/573 ,  G01N33/561

    CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502776 ,  G01N33/558

    摘要： Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a pre-concentration scheme to improve signal levels of corresponding reporter moieties.

    摘要翻译： 本文提供了用于敏感检测分析物的微流体装置和方法。 本文所述的方法和装置也可用于检测酶或催化剂对表面的直接或间接结合，例如具有结合在其上的分析物的表面。 本文公开的方法包括利用预浓缩方案来改善对应的报道部分的信号水平的实施方案。

    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
    3.
    发明授权
    Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers 有权
    处理具有受控孔隙率的开孔微孔聚合物泡沫的方法，用作血管移植物和支架盖

    公开(公告)号：US06702849B1

    公开(公告)日：2004-03-09

    申请号：US09460271

    申请日：1999-12-13

    申请人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    发明人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

    IPC分类号： A61F206

    CPC分类号： A61L31/16 ,  A61F2002/072 ,  A61L27/40 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/602 ,  A61L2300/606 ,  C08L67/04

    摘要： Porous vascular grafts and stent covers are formed of open-celled microcellular polymeric foams having a porosity that can be modified to be adapted for carrying and delivering different types of therapeutic drugs. A stent cover is formed of a tubular member including at least one layer of a porous, microcellular foam formed from a polymeric material capable of absorbing and releasing therapeutic drugs at predictable rates for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. A composite metal and polymer vascular graft is formed of an interior structural stent member, and an outer layer or coating of the porous, microcellular foam. The method of making the composite metal and polymer vascular graft involves providing an interior structural stent member with an outer layer or coating of the porous, microcellular foam, and can further comprise the step of loading a therapeutic drug into the outer layer of the porous, microcellular foam for delivery of the therapeutic drugs in localized drug therapy in a blood vessel.

    摘要翻译： 多孔血管移植物和支架覆盖物由具有孔隙率的开孔微孔聚合物泡沫形成，孔隙度可以被修饰以适于携带和递送不同类型的治疗药物。 支架盖由管状构件形成，该管状构件包括由能够以可预测的速率吸收和释放治疗药物的聚合材料形成的多孔微孔泡沫层，用于在血管中的局部药物治疗中递送治疗药物。 复合金属和聚合物血管移植物由内部结构支架构件和多孔微孔泡沫的外层或涂层形成。 制备复合金属和聚合物血管移植物的方法包括提供具有多孔，微孔泡沫体的外层或涂层的内部结构支架构件，并且还可以包括将治疗药物装载到多孔， 用于在血管中局部药物治疗中递送治疗药物的微孔泡沫。

    Inflatable member formed of liquid crystal polymeric material blend
    4.
    发明授权
    Inflatable member formed of liquid crystal polymeric material blend 有权
    由液晶聚合材料混合形成的充气构件

    公开(公告)号：US06325780B1

    公开(公告)日：2001-12-04

    申请号：US09394235

    申请日：1999-09-13

    申请人： Stephen G. Schaible ,  Debashis Dutta

    发明人： Stephen G. Schaible ,  Debashis Dutta

    IPC分类号： A61M2900

    CPC分类号： A61L29/126 ,  A61M25/10 ,  Y10T428/1334

    摘要： A catheter having an inflatable member formed of a liquid crystal polymeric material. The inflatable member is formed from a blend of a minor amount, preferably less than 10%, of liquid crystal polymer with a major amount of a non-liquid crystal polymer having LCP fibers that are highly oriented in the machine direction. The aspect ratio of the liquid crystal polymeric material fibers is greater than 10, so that the polymer blend has mechanical characteristics similar to a fiber-reinforced composite with improved strength and optimal compliance.

    摘要翻译： 一种具有由液晶聚合物材料形成的可膨胀构件的导管。 可膨胀构件由少量，优选小于10％的液晶聚合物与主要量的在机器方向上高度取向的LCP纤维的非液晶聚合物的共混物形成。 液晶聚合物材料纤维的纵横比大于10，使得聚合物共混物具有类似于纤维增强复合材料的机械特征，其具有改进的强度和最佳顺应性。

    Methods and Compositions for Detection of Biological Materials Using Microfluidic Devices
    6.
    发明申请
    Methods and Compositions for Detection of Biological Materials Using Microfluidic Devices 有权
    用微流控装置检测生物材料的方法和组合

    公开(公告)号：US20110177530A1

    公开(公告)日：2011-07-21

    申请号：US12842526

    申请日：2010-07-23

    申请人： Robert C. Corcoran ,  Debashis Dutta

    发明人： Robert C. Corcoran ,  Debashis Dutta

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54366 ,  B01L3/502753 ,  B01L3/502776 ,  G01N33/558

    摘要： Provided herein are microfluidic devices and methods useful for sensitive detection of analytes. The methods and devices described herein are also useful for detecting direct or indirect binding of enzymes or catalysts to a surface, for example a surface having analytes bound thereon. Methods disclosed herein include embodiments utilizing a pre-concentration scheme to improve signal levels of corresponding reporter moieties.

    摘要翻译： 本文提供了用于敏感检测分析物的微流体装置和方法。 本文所述的方法和装置也可用于检测酶或催化剂对表面的直接或间接结合，例如具有结合在其上的分析物的表面。 本文公开的方法包括利用预浓缩方案来改善对应的报道部分的信号水平的实施方案。

    Biodegradable polymers for use with implantable medical devices
    7.
    发明申请
    Biodegradable polymers for use with implantable medical devices 有权
    用于可植入医疗器械的可生物降解聚合物

    公开(公告)号：US20050232971A1

    公开(公告)日：2005-10-20

    申请号：US11155036

    申请日：2005-06-16

    申请人： Syed Hossainy ,  Debashis Dutta

    发明人： Syed Hossainy ,  Debashis Dutta

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/82

    CPC分类号： A61F2/82 ,  A61F2210/0004

    摘要： The present invention relates to a stent fabricated of or coated with a composition comprising a biodegradable hydrophobic polymer containing water-labile bonds such that a device fabricated of the composition or the surface of a device coated with the requisite mechanical characteristics required of a stent and the polymer erodes from its outer surface inward.

    摘要翻译： 本发明涉及一种由含有水不稳定键的可生物降解的疏水性聚合物的组合物制成或涂覆的支架，使得由组合物制造的装置或涂覆有支架所需的必要机械特性的装置的表面和 聚合物从其外表面向内侵蚀。

    System for blocking the passage of emboli through a body vessel
    8.
    发明授权
    System for blocking the passage of emboli through a body vessel 有权
    阻塞栓塞穿过身体血管的系统

    公开(公告)号：US06623450B1

    公开(公告)日：2003-09-23

    申请号：US09466366

    申请日：1999-12-17

    申请人： Debashis Dutta

    发明人： Debashis Dutta

    IPC分类号： A61M2900

    CPC分类号： A61F2/01 ,  A61F2230/0006

    摘要： An expandable filtering material expands within a body vessel (e.g. artery) when fluid flows through the vessel. Expandable pockets in the filtering material trap emboli released in the fluid. The filtering material is inserted into the vessel at a particular position distal to a lesion in the direction of the fluid flow. A protective sleeve covers the filtering material. An interventional device is disposed in the vessel at the lesion position to treat the lesion. The sleeve is removed from the expandable filtering material thereby expanding the filtering material within the vessel. The interventional device treats the lesion and opens up the vessel at the lesion position. The interventional device is thereafter removed. Retaining pockets in the expandable filtering material trap emboli released in the fluid of the body vessel.

    摘要翻译： 当流体流过容器时，可膨胀过滤材料在体内容器（例如动脉）内膨胀。 过滤材料中的可膨胀口袋中的栓塞释放在流体中。 过滤材料在流体流动方向上的病变远侧的特定位置处插入容器中。 保护套罩覆盖过滤材料。 将介入装置设置在病变位置处的血管中以治疗病变。 将套筒从可膨胀的过滤材料中取出，从而使过滤材料膨胀在容器内。 介入装置治疗病变并在病变位置打开血管。 之后移除介入装置。 在可膨胀的过滤材料中的保留凹陷栓塞释放在身体血管的流体中。

    Catheters having rapid-exchange and over-the-wire operating modes
    9.
    发明授权
    Catheters having rapid-exchange and over-the-wire operating modes 有权
    导管具有快速交换和线上操作模式

    公开(公告)号：US06458099B2

    公开(公告)日：2002-10-01

    申请号：US09929407

    申请日：2001-08-14

    申请人： Debashis Dutta ,  Cindy Nguyen ,  Eugene Serina ,  Kristin E. Welborn

    发明人： Debashis Dutta ,  Cindy Nguyen ,  Eugene Serina ,  Kristin E. Welborn

    IPC分类号： A61M2900

    CPC分类号： A61M25/104 ,  A61M2025/0183

    摘要： An intravascular catheter capable of both rapid-exchange and over-the-wire modes of operation having a relatively long proximal shaft portion, a relatively short distal section and an intermediate shaft section, which connects the proximal shaft section and the distal shaft section. In one embodiment, the intermediate shaft section includes a guide wire port and a first guide wire lumen which extends throughout both the intermediate and distal shaft section, and a second guide wire lumen which extends throughout the entire catheter shaft. In another embodiment, the intermediate shaft section includes a y-lumen junction which allows a first guide wire lumen introduced at the intermediate shaft section and a second guide wire lumen extending from the proximal end of the catheter shaft throughout the proximal shaft section to merge and communicate with a single distal guide wire lumen which extends from the intermediate shaft section to the distal end of the catheter shaft. In another embodiment, the catheter shaft includes a single guide wire lumen extending from the proximal end to the distal end wherein the guide wire lumen is defined by a proximal section and a distal section. The proximal section guide wire lumen includes a slit which allows a guide wire to be removed for rapid-exchange mode of operation or retained for over-the-wire mode of operation.

    摘要翻译： 一种能够具有快速交换和线上操作操作的血管内导管，其具有连接近端轴部分和远侧轴部分的相对较长的近端轴部分，相对较短的远端部分和中间轴部分。 在一个实施例中，中间轴部分包括延伸穿过中间和远侧轴部分的导丝端口和第一导丝管腔，以及延伸穿过整个导管轴的第二导丝管腔。 在另一个实施例中，中间轴部分包括允许在中间轴部段处引入的第一导丝管腔和从导管轴的近端延伸穿过近侧轴部分的第二导丝管腔的y管腔连接部， 与从中间轴部分延伸到导管轴的远端的单个远端导丝管腔连通。 在另一个实施例中，导管轴包括从近端延伸到远端的单个导丝管腔，其中导丝管腔由近端部分和远端部分限定。 近端部分导丝管腔包括狭缝，其允许将导丝移除以用于快速交换操作模式或保持用于线上操作模式。

    Catheters having rapid-exchange and over-the-wire operating modes
    10.
    发明授权
    Catheters having rapid-exchange and over-the-wire operating modes 有权
    导管具有快速交换和线上操作模式

    公开(公告)号：US06299595B1

    公开(公告)日：2001-10-09

    申请号：US09466365

    申请日：1999-12-17

    申请人： Debashis Dutta ,  Cindy Nguyen ,  Eugene Serina ,  Kristin E. Welborn

    发明人： Debashis Dutta ,  Cindy Nguyen ,  Eugene Serina ,  Kristin E. Welborn

    IPC分类号： A61M2900

    CPC分类号： A61M25/104 ,  A61M2025/0183

    摘要： An intravascular catheter capable of both rapid-exchange and over-the-wire modes of operation having a relatively long proximal shaft portion, a relatively short distal section and an intermediate shaft section, which connects the proximal shaft section and the distal shaft section. In one embodiment, the intermediate shaft section includes a guide wire port and a first guide wire lumen which extends throughout both the intermediate and distal shaft section, and a second guide wire lumen which extends throughout the entire catheter shaft. In another embodiment, the intermediate shaft section includes a y-lumen junction which allows a first guide wire lumen introduced at the intermediate shaft section and a second guide wire lumen extending from the proximal end of the catheter shaft throughout the proximal shaft section to merge and communicate with a single distal guide wire lumen which extends from the intermediate shaft section to the distal end of the catheter shaft. In another embodiment, the catheter shaft includes a single guide wire lumen extending from the proximal end to the distal end wherein the guide wire lumen is defined by a proximal section and a distal section. The proximal section guide wire lumen includes a slit which allows a guide wire to be removed for rapid-exchange mode of operation or retained for over-the-wire mode of operation.

    摘要翻译： 一种能够具有快速交换和线上操作操作的血管内导管，其具有连接近端轴部分和远侧轴部分的相对较长的近端轴部分，相对较短的远端部分和中间轴部分。 在一个实施例中，中间轴部分包括延伸穿过中间和远侧轴部分的导丝端口和第一导丝管腔，以及延伸穿过整个导管轴的第二导丝管腔。 在另一个实施例中，中间轴部分包括允许在中间轴部段处引入的第一导丝管腔和从导管轴的近端延伸穿过近侧轴部分的第二导丝管腔的y管腔连接部， 与从中间轴部分延伸到导管轴的远端的单个远端导丝管腔连通。 在另一个实施例中，导管轴包括从近端延伸到远端的单个导丝管腔，其中导丝管腔由近端部分和远端部分限定。 近端部分导丝管腔包括狭缝，其允许将导丝移除以用于快速交换操作模式或保持用于线上操作模式。