公开(公告)号：US20170224787A1

公开(公告)日：2017-08-10

申请号：US15492671

申请日：2017-04-20

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  C12N9/88 ,  C12N9/96 ,  A61K31/205

CPC classification number: A61K38/51 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/60 ,  A61K2300/00 ,  C12N9/88 ,  C12N9/96 ,  C12Y402/01022

Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20220125896A1

公开(公告)日：2022-04-28

申请号：US17362633

申请日：2021-06-29

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K47/60 ,  A61K9/00 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  C12N9/88 ,  C12N9/96

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US10941392B2

公开(公告)日：2021-03-09

申请号：US16739169

申请日：2020-01-10

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88 ,  A61K38/51 ,  B01D15/36 ,  B01D15/38

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

公开(公告)号：US20200276282A1

公开(公告)日：2020-09-03

申请号：US16824931

申请日：2020-03-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/205 ,  A61K47/60 ,  A61K9/00 ,  A61K45/06 ,  C12N9/88 ,  C12N9/96 ,  A61K31/198 ,  A61K31/385

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US10653755B2

公开(公告)日：2020-05-19

申请号：US15774755

申请日：2016-11-09

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/385 ,  A61K31/198 ,  A61K47/60 ,  C12N9/96 ,  C12N9/88 ,  A61K45/06 ,  A61K9/00 ,  A61K31/205

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.

公开(公告)号：US20180318404A1

公开(公告)日：2018-11-08

申请号：US15774755

申请日：2016-11-09

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Jan P. Kraus ,  Tomas Majtan ,  Erez Bublil

IPC: A61K38/51 ,  A61K31/205 ,  A61K47/60 ,  C12N9/96 ,  A61K9/00 ,  A61K45/06 ,  C12N9/88 ,  A61K31/198 ,  A61K31/385

CPC classification number: A61K38/51 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/205 ,  A61K31/385 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/60 ,  A61K2300/00 ,  C12N9/88 ,  C12N9/96 ,  C12Y402/01022

Abstract: Provided are compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.