公开(公告)号：US10537623B2

公开(公告)日：2020-01-21

申请号：US14869523

申请日：2015-09-29

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  A61K39/39 ,  A61K38/21 ,  A61K38/44 ,  A61K38/20 ,  C12N9/02

Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

公开(公告)号：US10463725B2

公开(公告)日：2019-11-05

申请号：US14882307

申请日：2015-10-13

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  C07K14/47 ,  A61K45/06 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/20 ,  A61K38/21 ,  A61K38/17

Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

公开(公告)号：US09592281B2

公开(公告)日：2017-03-14

申请号：US13888137

申请日：2013-05-06

Applicant: Toray Industries, Inc.

Inventor： Fumiyoshi Okano ,  Masaki Shimizu ,  Takanori Saito

IPC: A61K39/00 ,  A61K38/19 ,  C07K14/47 ,  C12N5/078 ,  C12N5/0783 ,  A61K38/00

CPC classification number: A61K39/0011 ,  A61K38/00 ,  A61K38/19 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C12N5/0634 ,  C12N5/0636 ,  A61K2300/00

Abstract: The invention relates to an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity that is selected from among polypeptides (a), (b), and (c): (a) a polypeptide of at least seven contiguous amino acids of the amino acid sequence shown by any even SEQ ID number selected from SEQ ID NOs: 2 to 30 listed in the Sequence Listing; (b) a polypeptide of at least seven amino acids having 90% or more sequence identity with the polypeptide (a); and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof, or a recombinant vector comprising a polynucleotide encoding said polypeptide and capable of expressing said polypeptide in vivo.

Abstract translation: 本发明涉及一种免疫诱导剂，其包含作为活性成分的至少一种具有免疫诱导活性的多肽，其选自多肽（a），（b）和（c）：（a）多肽 氨基酸序列的至少七个连续氨基酸由选自序列表中所列的SEQ ID NO：2至30的任何偶数SEQ ID号表示; （b）与多肽（a）具有90％或更多序列同一性的至少7个氨基酸的多肽; 以及（c）包含多肽（a）或（b）作为其部分序列的多肽，或包含编码所述多肽并能够在体内表达所述多肽的多核苷酸的重组载体。

公开(公告)号：US09416191B2

公开(公告)日：2016-08-16

申请号：US14452746

申请日：2014-08-06

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: A61K39/395 ,  C07K16/30 ,  C07K14/47 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K39/395 ,  C07K14/4748 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/732

Abstract: According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, wherein CAPRIN-1 is represented by any of the even-numbered sequences of SEQ ID NOS: 2 to 30, and wherein the partial polypeptide comprises the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence.

Abstract translation: 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分，其中CAPRIN-1由任何 的SEQ ID NO：2至30的偶数序列，并且其中所述部分多肽包含由SEQ ID NO：37表示的氨基酸序列或与氨基酸序列具有80％或更多序列同一性的氨基酸序列。

公开(公告)号：US09273130B2

公开(公告)日：2016-03-01

申请号：US14379876

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/30 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancers. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancers, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供了靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体而言，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学活性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含所述抗体或其片段作为活性成分。

公开(公告)号：US20150044221A1

公开(公告)日：2015-02-12

申请号：US14379868

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Shinichi Kobayashi ,  Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/18 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732

Abstract: This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与SEQ ID NO：5所示的氨基酸序列具有80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 氨基酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。

公开(公告)号：US12274745B2

公开(公告)日：2025-04-15

申请号：US16344689

申请日：2017-10-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi Okano ,  Takanori Saito

IPC: C07K16/46 ,  A61K31/4745 ,  A61K39/39 ,  A61K39/395 ,  A61K47/68 ,  A61P35/02

Abstract: The present invention provides a conjugate of an antibody or a fragment thereof linked to an immune activator, wherein the antibody or the fragment thereof has immunological reactivity with a CAPRIN-1 protein, and a pharmaceutical composition comprising the conjugate as an active ingredient for treatment and/or prevention of a cancer.

公开(公告)号：US11045534B2

公开(公告)日：2021-06-29

申请号：US16088682

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki Fujita ,  Fumiyoshi Okano

IPC: A61K39/395 ,  A61K39/00 ,  C07K14/54 ,  C07K14/555 ,  C07K14/705 ,  C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K35/76 ,  A61K38/21 ,  A61P35/00

Abstract: The present application relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MCEMP1 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

公开(公告)号：US09772332B2

公开(公告)日：2017-09-26

申请号：US14415520

申请日：2013-07-19

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayoshi Ido ,  Fumiyoshi Okano

IPC: G01N33/574

CPC classification number: G01N33/57496 ,  G01N33/57415 ,  G01N33/57484 ,  G01N2800/52

Abstract: This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against CAPRIN-1 having an amino acid sequence shown in any even-numbered SEQ ID NO shown in SEQ ID NOs: 2 to 30 in the Sequence Listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of CAPRIN-1 in a sample of a cancer patient in order to determine the administration of a therapeutic drug targeting CAPRIN-1 to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-CAPRIN-1 antibody.

公开(公告)号：US20150050283A1

公开(公告)日：2015-02-19

申请号：US14379872

申请日：2013-02-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi Okano ,  Takanori Saito ,  Takayoshi Ido ,  Yoshitaka Minamida

IPC: C07K16/18 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/732

Abstract: The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.

Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。