公开(公告)号：US20060243701A1

公开(公告)日：2006-11-02

申请号：US11379071

申请日：2006-04-18

申请人： Shogo Ono ,  Manabu Tomita ,  Koichi Igarashi ,  Takaaki Miyamoto

发明人： Shogo Ono ,  Manabu Tomita ,  Koichi Igarashi ,  Takaaki Miyamoto

IPC分类号： G01D15/00 ,  B41J2/15

CPC分类号： B41J2/1645 ,  B41J2/14072 ,  B41J2/1603 ,  B41J2/1623 ,  B41J2/1628 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1632 ,  B41J2/1635 ,  B41J2/1639

摘要： A liquid discharge head includes: a plurality of energy generating elements arranged in one direction on a substrate; a coating layer formed on the substrate and having formed therein a plurality of discharge ports opposed to the energy generating elements; and an individual passage formed on the substrate and extending in a direction orthogonal to a direction in which the energy generating elements are arranged. The coating layer on the individual passage has an opening formed therein.

摘要翻译： 液体排出头包括：在基板上沿一个方向布置的多个能量产生元件; 形成在所述基板上并且在其中形成有与所述能量产生元件相对的多个排出口的涂层; 以及形成在基板上并沿与能量产生元件布置的方向正交的方向延伸的单独通道。 单个通道上的涂层具有形成在其中的开口。

公开(公告)号：US07946680B2

公开(公告)日：2011-05-24

申请号：US11629222

申请日：2005-06-16

申请人： Shogo Ono ,  Manabu Tomita ,  Koichi Igarashi

发明人： Shogo Ono ,  Manabu Tomita ,  Koichi Igarashi

IPC分类号： B41J2/135

CPC分类号： B41J2/14072 ,  B41J2/1404 ,  B41J2/14145 ,  B41J2002/14387

摘要： There is provided a head including a chip 10 that has a semiconductor substrate 11, heating elements 12 disposed on the semiconductor substrate 11, coating layers 14 disposed on the semiconductor substrate 11 and having nozzles 14a arranged in regions above the respective heating elements 12, and individual channels 14b each communicating with the outside and the region above the corresponding heating element 12, wherein the semiconductor substrate 11 does not have a through hole communicating with each individual channel 14b; a ink feed member 21 having a common channel 21b, the ink feed member 21 being bonded to the chip 10 in such a manner that the common channel 21b communicates with the individual channels 14b; and a top 22 disposed on the chip 10 and the ink feed member 21 so as to seal the opening of the common channel 21b.

摘要翻译： 设置有具有半导体基板11的芯片10，配置在半导体基板11上的加热元件12，配置在半导体基板11上的涂布层14，配置在各加热元件12上方的喷嘴14a的芯片10，以及 各个通道14b各自与相应的加热元件12上方的外部和区域连通，其中半导体基板11不具有与各个通道14b连通的通孔; 具有公共通道21b的供墨构件21，墨供给构件21以公共通道21b与单个通道14b连通的方式结合到芯片10; 以及设置在芯片10和供墨部件21上的顶部22，以密封公共通道21b的开口。

公开(公告)号：US07216420B2

公开(公告)日：2007-05-15

申请号：US10393200

申请日：2003-03-20

申请人： Manabu Tomita ,  Koichi Igarashi

发明人： Manabu Tomita ,  Koichi Igarashi

IPC分类号： H05B3/00

CPC分类号： B41J2/1603 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1639 ,  B41J2/1645 ,  Y10T29/42 ,  Y10T29/49002 ,  Y10T29/49083 ,  Y10T29/49172 ,  Y10T29/49401 ,  Y10T29/49798 ,  Y10T29/49812

摘要： A print head manufacturing method in which satisfactory precision can be obtained by simple processes are provided. Projecting objects having a predetermined shape are formed on a substrate, and a setting resin is applied on the substrate and is set. Then, the projecting objects are removed so that ink cells and nozzles are formed. The thickness of the setting resin is determined such that tip portions of the projecting objects project above the setting resin and ink cells can be formed.

摘要翻译： 提供了通过简单的工艺可以获得令人满意的精度的打印头制造方法。 在基板上形成具有预定形状的投影物体，并将设定树脂施加在基板上并设定。 然后，移除投影物体，从而形成墨盒和喷嘴。 确定设定树脂的厚度，使得突出物体的末端部分突出于固化树脂上方，并且可以形成墨水池。

公开(公告)号：US5437995A

公开(公告)日：1995-08-01

申请号：US26257

申请日：1993-03-04

申请人： Yuzo Ichimori ,  Koichi Kondo ,  Koichi Igarashi ,  Masaharu Sendo

发明人： Yuzo Ichimori ,  Koichi Kondo ,  Koichi Igarashi ,  Masaharu Sendo

IPC分类号： C07K14/50 ,  C07K16/22 ,  C12N5/18 ,  C12P21/08 ,  C12N5/12

CPC分类号： C07K14/501 ,  C07K16/22

摘要： The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

摘要翻译： 本发明提供了产生对酸性成纤维细胞生长因子（aFGF）蛋白质的单克隆抗体的杂交细胞系。 通过将来自免疫小鼠的脾细胞与骨髓瘤细胞融合来建立杂交瘤。 将杂交瘤作为克隆进行培养，并测试从各克隆得到的抗体对aFGF蛋白的特异性。 抗体可以从培养生长培养基中获得，也可以从携带杂交瘤肿瘤的小鼠的腹水获得。 还公开了单克隆抗体的诊断和治疗用途。

公开(公告)号：US5360896A

公开(公告)日：1994-11-01

申请号：US7089

申请日：1993-01-19

申请人： Masaharu Senoo ,  Reiko Sasada ,  Koichi Igarashi

发明人： Masaharu Senoo ,  Reiko Sasada ,  Koichi Igarashi

IPC分类号： G06F1/28 ,  A61K38/00 ,  C07K14/50 ,  C07K13/00

CPC分类号： C07K14/50 ,  A61K38/00 ,  C07K2319/036 ,  C07K2319/75

摘要： Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.

摘要翻译： 公开了（1）成纤维细胞生长因子（FGF）的突变蛋白，其中引入了至少一个编码糖基化位点的核苷酸序列的DNA，（2）编码（1），（3）的突变蛋白的DNA 含有（2）的DNA的载体，（4）用（3）的载体转化的转化体，和（5）一种产生突变蛋白的方法，其包括在培养基中培养转化了酵母或动物细胞的转化体 （3）的载体，并且在培养基中产生和积累（1）的突变蛋白，从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力，稳定性和活性，并且有利地用作药物 。

公开(公告)号：US20120014625A1

公开(公告)日：2012-01-19

申请号：US13203453

申请日：2010-02-23

申请人： Koichi Igarashi ,  Tetsuya Saito ,  Yasushi Nagata ,  Toshifumi Mori ,  Hitoshi Mori

发明人： Koichi Igarashi ,  Tetsuya Saito ,  Yasushi Nagata ,  Toshifumi Mori ,  Hitoshi Mori

IPC分类号： B65D30/08 ,  B32B27/32 ,  B32B7/02

CPC分类号： B65D65/40 ,  A61J1/10 ,  B32B7/02 ,  B32B27/32 ,  B32B27/327 ,  B32B2250/03 ,  B32B2250/05 ,  B32B2250/242 ,  B32B2270/00 ,  B32B2307/306 ,  B32B2307/308 ,  B32B2307/412 ,  B32B2307/558 ,  B32B2307/72 ,  B32B2439/46 ,  B32B2439/80 ,  B65D75/566 ,  B65D75/5883 ,  Y10T428/24975 ,  Y10T428/24992

摘要： A multilayer film according to the present invention is a multilayer film, in which an outermost layer and an innermost layer are laminated via an intermediate layer arranged from one to three layers, with the intermediate layer including at least one layer being made of 0 to 55 weight % of a linear polyethylene having a density of 0.910 to 0.930 g/cm3, 5 to 15 weight % of a high-density polyethylene having a density of 0.950 to 0.970 g/cm3, and 35 to 85 weight % of a linear polyethylene having a density of 0.900 to 0.910 g/cm3 and polymerized using a single-site catalyst, and having a density lower than the outermost layer and the innermost layer, and each of the outermost layer and the innermost layer being formed of a polyethylene or a mixture of two or more types of polyethylene.

摘要翻译： 根据本发明的多层膜是通过经过1至3层布置的中间层层压最外层和最内层的多层膜，中间层至少包含一层为0至55层 密度为0.910〜0.930g / cm 3的线性聚乙烯的重量％，密度为0.950〜0.970g / cm 3的高密度聚乙烯为5〜15重量％，以及35〜85重量％的具有 密度为0.900〜0.910g / cm 3，使用单中心催化剂进行聚合，密度低于最外层和最内层，最外层和最内层由聚乙烯或混合物形成 的两种或更多种类型的聚乙烯。

公开(公告)号：US07661633B2

公开(公告)日：2010-02-16

申请号：US11295552

申请日：2005-12-07

申请人： Koichi Igarashi ,  Junpei Ichihashi

发明人： Koichi Igarashi ,  Junpei Ichihashi

IPC分类号： F16B15/00

CPC分类号： H02G3/30 ,  F16L3/2334 ,  Y10T24/1406

摘要： A clamp 1 comprises a band 3, a buckle 5 having a support surface 18 against which a long component wound by the band is held, and a clip 6 extending from the buckle 5 and secured to, e.g., a body panel. The buckle 5 comprises a pawl 15 for engaging ratchet teeth 17 on the band, a first guide 25 and a second guide 26 forming an insertion passage 19 for guiding the band 3 and restraining the band 3 inside the insertion passage 19. The second guide 26 is formed in a shape by which the rear portion 30 of the insertion passage 19 including the outlet is parallel to the support surface 18, and the first guide 25 is formed in a shape by which the front portion 31 of the insertion passage 19 including the inlet is connected to the rear portion 30 at an acute angle of inclination 29 with respect to the rear portion 30.

摘要翻译： 夹具1包括带3，具有支撑表面18的带扣5，保持由带缠绕的长部件，以及从扣环5延伸并固定到例如身体面板的夹子6。 带扣5包括用于接合带上的棘齿17的棘爪15，形成用于引导带3并将带3限制在插入通道19内部的插入通道19的第一引导件25和第二引导件26.第二引导件26 形成为包括出口的插入通道19的后部30平行于支撑表面18的形状，并且第一引导件25形成为包括插入通道19的前部31的形状 入口以相对于后部30的锐角29相对于后部30连接。

公开(公告)号：US20080223974A1

公开(公告)日：2008-09-18

申请号：US12075132

申请日：2008-03-07

申请人： Takashi Ueki ,  Teruo Tamada ,  Teiji Wagatsuma ,  Takashi Fujimi ,  Koichi Igarashi

发明人： Takashi Ueki ,  Teruo Tamada ,  Teiji Wagatsuma ,  Takashi Fujimi ,  Koichi Igarashi

IPC分类号： H01F5/00 ,  B65H54/00 ,  H01F41/08

CPC分类号： B65H75/06 ,  B65H55/04 ,  H01F5/00 ,  H01F41/074 ,  Y10T29/49002

摘要： A polygonal coil having a substantially square shape is manufactured by winding a conductive wire in the diameter direction of the core on the core in an overlapping manner by the use of a winding jig in which a first collar portion and a second collar portion are disposed at both ends of a core so as to be opposed to each other and four rod-shaped protrusions are disposed on a surface of the first collar portion opposed to the second collar portion so as to protrude in a radial shape centered on an end of the core. As a result, it is possible to obtain a polygonal coil with high precision.

摘要翻译： 通过使用其中第一轴环部分和第二轴环部分设置在其中的卷绕夹具以重叠的方式将芯线的直径方向上的导线缠绕在芯上，制造具有大致正方形形状的多边形线圈 芯的两端彼此相对，并且四个棒状突起设置在与第二轴环部相对的第一轴环部的表面上，以便以芯的一端为中心的径向形状突出 。 结果，可以高精度地获得多边形线圈。

公开(公告)号：US5852177A

公开(公告)日：1998-12-22

申请号：US301460

申请日：1989-01-24

申请人： Masaharu Senoo ,  Reiko Sasada ,  Tsutomu Kurokawa ,  Koichi Igarashi

发明人： Masaharu Senoo ,  Reiko Sasada ,  Tsutomu Kurokawa ,  Koichi Igarashi

IPC分类号： A61K38/00 ,  C07K14/50 ,  C07K14/55 ,  C07K16/22

CPC分类号： C07K16/22 ,  C07K14/503 ,  C07K14/55 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/75

摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.

摘要翻译： 碱性成纤维细胞生长因子（bFGF）的突变蛋白具有成纤维细胞生长促进活性，毛细血管内皮细胞生长刺激活性和血管生成活性，稳定性高，毒性低。 因此，本发明的突变蛋白有利地用作燃烧等的愈合促进剂，血栓形成治疗药等，以及细胞培养促进剂。

公开(公告)号：US5750371A

公开(公告)日：1998-05-12

申请号：US471570

申请日：1995-06-06

申请人： Masaharu Senoo ,  Tatsuya Watanabe ,  Koichi Igarashi

发明人： Masaharu Senoo ,  Tatsuya Watanabe ,  Koichi Igarashi

IPC分类号： A61K38/00 ,  C07K14/71 ,  C12N15/12 ,  C07H21/00 ,  C12N15/63

CPC分类号： C07K14/71 ,  A61K38/00

摘要： Disclosed are (1) a water-soluble mutein of an animal protein having activity as a receptor for a fibroblast growth factor (FGF) protein, (2) a recombinant DNA having a nucleotide sequence coding for the above water-soluble mutein, (3) a vector containing the above recombinant DNA, (4) a transformant transformed with the above vector, and (5) a process for producing the water-soluble mutein which comprises cultivating the above transformant in a culture medium, the mutein being useful as therapeutic agents or to enhance cell proliferation activity.

摘要翻译： 公开了（1）具有作为成纤维细胞生长因子（FGF）蛋白的受体的活性的动物蛋白质的水溶性突变蛋白，（2）具有编码上述水溶性突变蛋白的核苷酸序列的重组DNA（3 ）含有上述重组DNA的载体，（4）用上述载体转化的转化体，和（5）一种生产水溶性突变蛋白的方法，其包括在培养基中培养上述转化体，所述突变蛋白可用作治疗 药剂或增强细胞增殖活性。