公开(公告)号：US5437995A

公开(公告)日：1995-08-01

申请号：US26257

申请日：1993-03-04

申请人： Yuzo Ichimori ,  Koichi Kondo ,  Koichi Igarashi ,  Masaharu Sendo

发明人： Yuzo Ichimori ,  Koichi Kondo ,  Koichi Igarashi ,  Masaharu Sendo

IPC分类号： C07K14/50 ,  C07K16/22 ,  C12N5/18 ,  C12P21/08 ,  C12N5/12

CPC分类号： C07K14/501 ,  C07K16/22

摘要： The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

摘要翻译： 本发明提供了产生对酸性成纤维细胞生长因子（aFGF）蛋白质的单克隆抗体的杂交细胞系。 通过将来自免疫小鼠的脾细胞与骨髓瘤细胞融合来建立杂交瘤。 将杂交瘤作为克隆进行培养，并测试从各克隆得到的抗体对aFGF蛋白的特异性。 抗体可以从培养生长培养基中获得，也可以从携带杂交瘤肿瘤的小鼠的腹水获得。 还公开了单克隆抗体的诊断和治疗用途。

公开(公告)号：US4681848A

公开(公告)日：1987-07-21

申请号：US534091

申请日：1983-09-20

申请人： Kyozo Tsukamoto ,  Yuzo Ichimori ,  Mitsuhiro Wakimasu

发明人： Kyozo Tsukamoto ,  Yuzo Ichimori ,  Mitsuhiro Wakimasu

IPC分类号： A61K39/395 ,  C07K7/06 ,  C07K7/08 ,  C07K14/57 ,  C07K16/24 ,  C12N5/00 ,  C12N11/02 ,  C12N15/00 ,  C12P21/00 ,  C12P21/04 ,  G01N33/68

CPC分类号： C07K14/57 ,  C07K16/249 ,  G01N33/6866 ,  Y10S435/948 ,  Y10S530/806 ,  Y10S530/809 ,  Y10S530/861 ,  Y10S930/142

摘要： The invention relates to novel polypeptide of the formula ##STR1## wherein X is a bond, or a peptide or amino acid residue 1 to 16 amino acids counting from the C terminus of the peptide chain of ##STR2## and Y is a peptide or amino acid residue having 1 to 5 amino acids counting from the N terminus of the peptide chain of ##STR3## and conjugate between the same and a carrier protein, as well as hydridoma and monoclonal antibody derived by the use of the polypeptide or the conjugate, and a method of detecting and of purifying human gamma-interferon using the antibodies.

摘要翻译： 本发明涉及下式新颖的多肽，其中X是一个键，或肽或氨基酸残基从图像的肽链的C末端计数的1到16个氨基酸，而Y是一个 具有1至5个氨基酸的肽或氨基酸残基从“IMAGE”的肽链的N末端计数，并且其与载体蛋白之间的结合物，以及通过使用多肽或 缀合物，以及使用抗体检测和纯化人γ-干扰素的方法。

公开(公告)号：US6001580A

公开(公告)日：1999-12-14

申请号：US622277

申请日：1996-03-27

申请人： Akiyoshi Tani ,  Yuzo Ichimori

发明人： Akiyoshi Tani ,  Yuzo Ichimori

IPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/53 ,  A61K39/395 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K16/40 ,  G01N33/573

摘要： The monoclonal antibody generated by immunizing a mammal with human MAP kinase ERK1 and the polyclonal antibody generated by immunizing an animal with the phosphorylation region of the sequence of MAP kinase or a fragment of human MAP kinase are used either alone or in combination to detect and assay various MAP kinase species including ERK2.

摘要翻译： 通过用人MAP激酶ERK1免疫哺乳动物产生的单克隆抗体和通过用MAP激酶序列的磷酸化区域或人MAP激酶的片段免疫动物产生的多克隆抗体单独或组合地用于检测和测定 各种MAP激酶种类包括ERK2。

公开(公告)号：US5527811A

公开(公告)日：1996-06-18

申请号：US274263

申请日：1994-07-13

申请人： Hideaki Natsugari ,  Tetsuji Imamoto ,  Yuzo Ichimori

发明人： Hideaki Natsugari ,  Tetsuji Imamoto ,  Yuzo Ichimori

IPC分类号： C07D217/24 ,  C07D401/12 ,  C07D521/00 ,  A61K31/47 ,  C07D405/06

CPC分类号： C07D231/12 ,  C07D217/24 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

摘要： Compounds represented by the formula: ##STR1## wherein the ring A and the ring B each stand for an optionally substituted benzene ring; Ar stands for an optionally substituted aryl group or an optionally substituted heterocyclic group; Q stands for an oxygen atom or a sulfur atom; R stands for a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group; X stands for --O-- or --NR.sup.1 -- wherein R.sup.1 stands for a hydrogen atom or an optionally substituted hydrocarbon group; Y stands for --O--, --NR.sup.2 -- wherein R.sup.2 stands for a hydrogen atom or an optionally substituted hydrocarbon group, or a bond; m denotes 1, 2 or 3, and n denotes 0, 1 or 2, and salts thereof which have excellent calcium- or substance P receptor-antagonistic activity, being useful for treating a cerebralvascular disorder in mammals such as cerebralischemia, cerebral edema and neuronal damage, their production and use.

摘要翻译： 由下式表示的化合物：其中环A和环B各自代表任选取代的苯环; Ar表示任选取代的芳基或任选取代的杂环基; Q代表氧原子或硫原子; R代表氢原子，任选取代的烃基，任选取代的羟基或任选取代的氨基; X代表-O-或-NR1-，其中R1代表氢原子或任选取代的烃基; Y代表-O-，-NR2-，其中R2代表氢原子或任选取代的烃基，或键; m表示1,2或3，n表示0,1或2，其具有优异的钙或物质P受体拮抗活性的盐可用于治疗哺乳动物如脑缺血，脑水肿和神经元的脑血管障碍 损坏，生产和使用。

公开(公告)号：US06495604B1

公开(公告)日：2002-12-17

申请号：US09622392

申请日：2000-08-14

申请人： Yuzo Ichimori ,  Masayuki Ii ,  Katsumi Itoh ,  Tomoyuki Kitazaki ,  Junji Yamada

发明人： Yuzo Ichimori ,  Masayuki Ii ,  Katsumi Itoh ,  Tomoyuki Kitazaki ,  Junji Yamada

IPC分类号： A61K3118

CPC分类号： C07D249/08 ,  C07C311/14 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2601/18 ,  C07D249/06 ,  C07D257/04 ,  C07D275/06

摘要： The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group represented by the formula: OR1 (wherein R1 represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents) or a group represented by the formula: wherein R1b represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R1c is, same with or different from R1b, a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R0 represents a hydrogen atom or an aliphatic hydrocarbon group, or R and R0 represents a bond with each other, Ar represents an aromatic hydrocarbon group optionally having substituents, and n is an integer of 1 to 4, or a salt thereof, which is a agent for preventing or treating diseases such as cardiac disease, autoimmune disease, septick shock, etc.

摘要翻译： 本发明提供由下式表示的化合物：其中R表示任选具有取代基的脂族烃基，任选具有取代基的芳族烃基，任选具有取代基的杂环基，由式OR1表示的基团（其中R1表示 氢原子或任选具有取代基的脂族烃基）或由下式表示的基团：其中R 1b表示氢原子或任选具有取代基的脂族烃基，R 1c与R 1b相同或不同，为氢原子或脂族 任选具有取代基的烃基，R 0表示氢原子或脂族烃基，或R和R 0表示彼此的键，Ar表示任选具有取代基的芳香族烃基，n表示1〜4的整数，或者 其盐，其是用于预防或治疗诸如心脏病的疾病的药剂 麻疹，败血性休克等