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公开(公告)号：US5750371A
公开(公告)日：1998-05-12
申请号：US471570
申请日：1995-06-06
摘要： Disclosed are (1) a water-soluble mutein of an animal protein having activity as a receptor for a fibroblast growth factor (FGF) protein, (2) a recombinant DNA having a nucleotide sequence coding for the above water-soluble mutein, (3) a vector containing the above recombinant DNA, (4) a transformant transformed with the above vector, and (5) a process for producing the water-soluble mutein which comprises cultivating the above transformant in a culture medium, the mutein being useful as therapeutic agents or to enhance cell proliferation activity.
摘要翻译： 公开了（1）具有作为成纤维细胞生长因子（FGF）蛋白的受体的活性的动物蛋白质的水溶性突变蛋白，（2）具有编码上述水溶性突变蛋白的核苷酸序列的重组DNA（3 ）含有上述重组DNA的载体，（4）用上述载体转化的转化体，和（5）一种生产水溶性突变蛋白的方法，其包括在培养基中培养上述转化体，所述突变蛋白可用作治疗 药剂或增强细胞增殖活性。
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公开(公告)号：US5360896A
公开(公告)日：1994-11-01
申请号：US7089
申请日：1993-01-19
申请人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/036 , C07K2319/75
摘要： Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.
摘要翻译： 公开了（1）成纤维细胞生长因子（FGF）的突变蛋白，其中引入了至少一个编码糖基化位点的核苷酸序列的DNA，（2）编码（1），（3）的突变蛋白的DNA 含有（2）的DNA的载体，（4）用（3）的载体转化的转化体，和（5）一种产生突变蛋白的方法，其包括在培养基中培养转化了酵母或动物细胞的转化体 （3）的载体，并且在培养基中产生和积累（1）的突变蛋白，从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力，稳定性和活性，并且有利地用作药物 。
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公开(公告)号：US5852177A
公开(公告)日：1998-12-22
申请号：US301460
申请日：1989-01-24
CPC分类号： C07K16/22 , C07K14/503 , C07K14/55 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.
摘要翻译： 碱性成纤维细胞生长因子（bFGF）的突变蛋白具有成纤维细胞生长促进活性，毛细血管内皮细胞生长刺激活性和血管生成活性，稳定性高，毒性低。 因此，本发明的突变蛋白有利地用作燃烧等的愈合促进剂，血栓形成治疗药等，以及细胞培养促进剂。
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公开(公告)号：US5464943A
公开(公告)日：1995-11-07
申请号：US275635
申请日：1994-07-15
申请人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
发明人： Masaharu Senoo , Reiko Sasada , Koichi Igarashi
CPC分类号： C07K14/503 , C07K14/50 , C12N15/625 , A61K38/00 , C07K2319/036 , C07K2319/75 , C07K2319/91
摘要： Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.
摘要翻译： 公开了（1）成纤维细胞生长因子（FGF）的突变蛋白，其中引入了至少一个编码糖基化位点的核苷酸序列的DNA，（2）编码（1），（3）的突变蛋白的DNA 含有（2）的DNA的载体，（4）用（3）的载体转化的转化体，和（5）一种产生突变蛋白的方法，其包括在培养基中培养转化了酵母或动物细胞的转化体 （3）的载体，并且在培养基中产生和积累（1）的突变蛋白，从而提高了其中引入至少一个糖基化位点的FGF突变蛋白的生产力，稳定性和活性，并且有利地用作药物 。
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5.发明申请公开(公告)号：US20100244609A1
公开(公告)日：2010-09-30
申请号：US12816123
申请日：2010-06-15
IPC分类号： H02K1/27
CPC分类号： H02K1/2766 , H02K1/276
摘要： A permanent magnet type electric rotary machine includes a stator including a stator core having teeth and slots, and a rotor provided with permanent magnets as magnet poles in a rotor core. A pole core portion which between each of the permanent magnets and an outer surface of the rotor core is provided with a plurality of pole slits. A region of the pole core portion is defined by concave portions provided on q-axes to be interpolars on both sides of the pole core portion, and thereby configured that a gap between the outer surface on the q-axis of the rotor core and an inner surface of the stator core is larger than a gap between the outer surface on the d-axis of the pole core portion and the inner surface of the stator, so that magnetic fluxes from the permanent magnet pass through the pole core portion concentrately.
摘要翻译： 一种永磁式电动旋转机械，其特征在于，包括具有齿和槽的定子铁心的定子和在转子铁芯中设置有作为磁极的永久磁铁的转子。 在每个永磁体和转子芯的外表面之间的极芯部分设置有多个极狭缝。 磁极芯部的区域由设置在q轴上的凹部限定为在磁极芯部的两侧上的内插，并且由此构成为转子芯的q轴上的外表面与 定子铁芯的内表面大于极芯部分的d轴外表面与定子内表面之间的间隙，从而永久磁铁的磁通集中地通过极芯部分。
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6.发明授权公开(公告)号：US07768172B2
公开(公告)日：2010-08-03
申请号：US11780157
申请日：2007-07-19
IPC分类号： H02K21/12
CPC分类号： H02K1/2766 , H02K1/276
摘要： A permanent magnet type electric rotary machine includes a stator including a stator core having teeth and slots, and a rotor provided with permanent magnets as magnet poles in a rotor core. A pole core portion which between each of the permanent magnets and an outer surface of the rotor core is provided with a plurality of pole slits. A region of the pole core portion is defined by concave portions provided on q-axes to be interpolars on both sides of the pole core portion, and thereby configured that a gap between the outer surface on the q-axis of the rotor core and an inner surface of the stator core is larger than a gap between the outer surface on the d-axis of the pole core portion and the inner surface of the stator, so that magnetic fluxes from the permanent magnet pass through the pole core portion concentrately.
摘要翻译： 一种永磁式电动旋转机械，其特征在于，包括具有齿和槽的定子铁心的定子和在转子铁芯中设置有作为磁极的永久磁铁的转子。 在每个永磁体和转子芯的外表面之间的极芯部分设置有多个极狭缝。 磁极芯部的区域由设置在q轴上的凹部限定为在磁极芯部的两侧上的内插，并且由此构成为转子芯的q轴上的外表面与 定子铁芯的内表面大于极芯部分的d轴外表面与定子内表面之间的间隙，从而永久磁铁的磁通集中地通过极芯部分。
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7.发明申请Drug for treating hemophilia and method of treating hemophilia using the same 审中-公开用于治疗血友病的药物及使用其治疗血友病的方法公开(公告)号：US20060240114A1
公开(公告)日：2006-10-26
申请号：US10549555
申请日：2004-03-17
申请人： Masakazu Ueda , Shunichi Kuroda , Katsuyuki Tanizawa , Masaharu Senoo , Akihiko Kondo , Thierry Vandendriessche , Maurinee Chuah
发明人： Masakazu Ueda , Shunichi Kuroda , Katsuyuki Tanizawa , Masaharu Senoo , Akihiko Kondo , Thierry Vandendriessche , Maurinee Chuah
CPC分类号： C12N9/644 , A61K9/5068 , A61K38/37 , A61K47/6925 , A61K48/0008 , B82Y5/00 , C07K14/755 , C12N15/88 , C12Y304/21022
摘要： A therapeutic product or drug for therapy of hemophilia may be produced by a simplified method including embedding genes of the blood clotting factors VIII (IX) for therapy of hemophilia in hollow nano particles obtained on expressing the protein having a particle forming function, such as hepatitis B virus surface antigen protein, in eucaryotic cells. The drug so produced is able to introduce the genes of the blood clotting factors efficaciously into liver cells with the least risk of side effects.
摘要翻译： 用于治疗血友病的治疗产品或药物可以通过简单的方法产生，包括将用于治疗血友病的凝血因子VIII（IX）的基因嵌入到表达具有颗粒形成功能的蛋白质所获得的中空纳米颗粒中，例如肝炎 B病毒表面抗原蛋白，在真核细胞中。 如此产生的药物能够有效地将血液凝固因子的基因引入肝细胞中，并且副作用的风险最小。
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公开(公告)号：US5439886A
公开(公告)日：1995-08-08
申请号：US254493
申请日：1994-06-06
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/30 , C12N15/12 , C12P21/08 , A61K39/00 , C07H19/00 , C07K2/00 , C07K4/00
CPC分类号： C07K16/30 , C07K14/47 , C07K14/705 , A61K38/00
摘要： The present invention relates to a monclonal antibody capable of suppressing the motility of cancer cells, a polypeptide recognizable by said anti-cancer antibody and its fragment peptides which is capable of suppressing the motility of cancer cells.The present invention also relates to a production and a use for preventing the matastasis of cancer thereof.
摘要翻译： 本发明涉及能够抑制癌细胞的运动性的单克隆抗体，能够抑制癌细胞的运动性的可被所述抗癌抗体识别的多肽及其片段肽。 本发明还涉及用于预防癌症的转移的生产和用途。
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9.发明授权公开(公告)号：US08491280B2
公开(公告)日：2013-07-23
申请号：US12533097
申请日：2009-07-31
申请人： Hirotaka Kameya , Masaru Yamasaki , Toshiyuki Ajima , Masaharu Senoo , Hideharu Tanaka , Norinaga Suzuki
发明人： Hirotaka Kameya , Masaru Yamasaki , Toshiyuki Ajima , Masaharu Senoo , Hideharu Tanaka , Norinaga Suzuki
IPC分类号： F04C18/16
CPC分类号： F04B17/03 , F04C18/16 , F04C28/06 , F04C28/08 , F04C2270/051 , F04C2270/19 , F04C2270/701
摘要： An oil-flooded screw compressor drives a pair of rotors at a rotational speed which is low enough not to increase torque for a short amount of time after start-up and accelerates the pair of rotors up to a normal-operation rotational speed after oil discharge. Alternatively, the oil-flooded screw compressor rotates the pair of rotors for a short amount of time after the remaining compressed gas is discharged after a halt, thereby allowing the oil accumulated inside the working chambers to be discharged and ensuring smooth start-up after the halt.
摘要翻译： 充油螺杆式压缩机驱动一对转子，旋转速度足够低，在启动后不会在短时间内增加扭矩，并且在排油后将一对转子加速至正常操作转速 。 或者，油压螺杆式压缩机在停止后剩余的压缩气体排出之后使一对转子旋转一段时间，从而允许积聚在工作室内的油排出，并确保顺利启动 停。
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10.发明授权公开(公告)号：US07659651B2
公开(公告)日：2010-02-09
申请号：US11836876
申请日：2007-08-10
申请人： Koji Obata , Masaharu Senoo , Takeshi Obata , Akihiro Sekine , Mituru Itou , Takashi Yasuhara , Takayuki Koizumi
发明人： Koji Obata , Masaharu Senoo , Takeshi Obata , Akihiro Sekine , Mituru Itou , Takashi Yasuhara , Takayuki Koizumi
CPC分类号： H02K3/28 , B60L11/123 , B60L11/14 , B60L15/007 , B60L2220/12 , B60L2220/14 , B60L2260/28 , Y02T10/6217 , Y02T10/641 , Y02T10/645 , Y02T10/7005 , Y02T10/7077 , Y10T29/49009
摘要： A rotating electric machine includes a stator core of a cylindrical shape, a rotor core coaxially rotating inside the stator core, and a plurality of coils each formed by winding magnet wires using a slot formed axially in either the stator core or the rotor core, or both: it is preferable that each of the coils be split into a plurality of coil groups, that starting sections of winding of the magnet wires in one of the coil groups be wound adjacently to ending sections of winding of the magnet wires in another of the coil groups, and that the starting sections and ending sections of winding of the magnet wires in the two coil groups be connected at respective outgoing wire ends to one another, outside the slots.
摘要翻译： 旋转电机包括圆柱形的定子芯，在定子铁芯内部同轴旋转的转子芯，以及多个线圈，每个线圈通过使用在定子铁心或转子铁心中轴向形成的槽来缠绕电磁线，或 两者：优选的是，每个线圈被分成多个线圈组，其中一个线圈组中的磁体线的卷绕的起始部分相邻地缠绕在磁体线的另一个中的另一个中 线圈组，并且两个线圈组中的电线的绕组的起始部分和结束部分在相应的出线部分彼此连接，在槽外。
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