公开(公告)号：US09969431B2

公开(公告)日：2018-05-15

申请号：US15233483

申请日：2016-08-10

申请人： Grzegorz Sopel ,  Rajkumar Rajagopalan ,  Joseph V Rozenbaum ,  Hassan H El-Hor ,  Rebecca L Tanguay ,  Zheng Qin ,  Michael Dreer ,  Shakti P Chavan ,  Venkata Vinod Pasumarthi

发明人： Grzegorz Sopel ,  Rajkumar Rajagopalan ,  Joseph V Rozenbaum ,  Hassan H El-Hor ,  Rebecca L Tanguay ,  Zheng Qin ,  Michael Dreer ,  Shakti P Chavan ,  Venkata Vinod Pasumarthi

IPC分类号： B62D21/15 ,  B62D21/02 ,  B60R19/32

CPC分类号： B62D21/152 ,  B60R19/34 ,  B62D21/02

摘要： In at least one implementation, a structural rail for a vehicle includes a main body and a front portion. The main body has an upper wall, a lower wall, an inner sidewall and an outer sidewall spaced from the inner sidewall. The front portion has a rear end adjacent to the second end of the main body and a front end spaced from the rear end. The main body has a first bend between the first end and second end so that a portion of the main body is angled outwardly and an included angle of less than 180 degrees is provided in the outer sidewall. The rail also includes a second bend between the first bend and the front end, and the second bend further angles at least part of the front portion outwardly relative to the outwardly angled portion of the main body.

公开(公告)号：US09676418B1

公开(公告)日：2017-06-13

申请号：US14996508

申请日：2016-01-15

申请人： Abdul Kareem Mohammed ,  Zheng Qin ,  Hassan H El-Hor ,  Rajkumar Rajagopalan ,  Rebecca L Tanguay ,  Michael G Dreer ,  Amanda J French ,  Alan J Demorow

发明人： Abdul Kareem Mohammed ,  Zheng Qin ,  Hassan H El-Hor ,  Rajkumar Rajagopalan ,  Rebecca L Tanguay ,  Michael G Dreer ,  Amanda J French ,  Alan J Demorow

IPC分类号： B62D21/11 ,  B62D21/15 ,  B60R19/34

CPC分类号： B62D21/152 ,  B60R19/34 ,  B62D21/11 ,  B62D21/15 ,  B62D21/155 ,  B62D25/08

摘要： A vehicle crossmember assembly including a pair of main rails, a crossmember, and a pair of pedestals is provided. The main rails are laterally spaced apart. The crossmember is transverse to the main rails. The pedestals extend between and connect lateral ends of the crossmember to the main rails. Each pedestal has a lower end disposed adjacent to the crossmember and an upper end that projects upwardly from the crossmember. Fasteners connect the pedestals to the main rails. Each pedestal has a sleeve disposed at the upper end. Each sleeve has a sleeve wall defining a bore that receives one of the fasteners and each sleeve has a slit in the sleeve wall. Each slit provides a release path through which one of the fasteners can pull through the sleeve wall during an impact event, allowing the pedestals to detach from the main rails.

公开(公告)号：US20070148159A1

公开(公告)日：2007-06-28

申请号：US11313377

申请日：2005-12-22

申请人： Paul Reid ,  Zheng Qin

发明人： Paul Reid ,  Zheng Qin

IPC分类号： A61K38/48 ,  A61K31/60

CPC分类号： A61K38/1703 ,  A61K31/60

摘要： A method of producing analgesia and enhancing analgesia is disclosed. The method includes administering a beta-neurotoxin that is characterized by its ability to bind to pre- and postsynaptic receptors resulting in the inhibition of neurotransmission.

摘要翻译： 公开了一种制备镇痛和增强止痛的方法。 该方法包括施用β-神经毒素，其特征在于其结合前和突触后受体的能力，导致神经传递的抑制。

公开(公告)号：US11628883B2

公开(公告)日：2023-04-18

申请号：US17130226

申请日：2020-12-22

申请人： Lakshmi P Bhatta ,  Zheng Qin ,  Hassan H El-Hor

发明人： Lakshmi P Bhatta ,  Zheng Qin ,  Hassan H El-Hor

IPC分类号： B62D21/15 ,  B60R19/18 ,  B60R19/24

摘要： A vehicle includes a vehicle frame, a vehicle bumper and a load transfer assembly. The vehicle bumper is coupled to a front end of the vehicle frame and includes a center beam and a bumper beam extension that extends laterally from an end of the center beam. The load transfer assembly includes first and second pivot pins and a load beam. The first pivot pin is fixed to the bumper beam extension and the second pivot pin is fixed to the vehicle frame. The load beam has a first end pivotably coupled to the first pivot pin and a second end pivotably coupled to the second pivot pin. The load beam is configured to load the vehicle frame in a lateral direction upon a vehicle impact event.

公开(公告)号：US20060034823A1

公开(公告)日：2006-02-16

申请号：US10917143

申请日：2004-08-13

申请人： Paul Reid ,  Zheng Qin

发明人： Paul Reid ,  Zheng Qin

IPC分类号： A61K38/48 ,  A61K31/60

CPC分类号： A61K38/465 ,  A61K31/60 ,  C12Y301/01004 ,  A61K2300/00

摘要： Disclosed a pharmaceutical composition including one of crotoxin, mojavetoxin or a related toxin and a carrier for use in the treatment of chronic pain, especially to the treatment of heretofore intractable pain such as that associated with advanced cancer wherein the treatment is independent of the reduction of tumors. The crotoxin is preferably obtained from the snake Crotalus durissus terrificus and the mojavetoxin is obtained from the rattlesnake Crotalus scutulatus scutulatus. Preferably the composition further comprises an effective amount of acetylsalicylic acid whereby the toxin and acetylsalicylic acid together produce a synergistic effect providing enhanced pain relief. The composition of the invention may be delivered in parenteral (i.p.) (intravenous, intramuscular or subcutaneous) applications. Alternatively, the composition may be applied as a topical application. The biological activity of the composition is characterized by its ability to bind to presynaptic and postsynapic receptor sites. This results in an inhibition of aceylcholine release and activity.

摘要翻译： 本发明公开了一种药物组合物，其中包括一种抗生素，莫霍伊金或相关毒素，以及用于治疗慢性疼痛的载体，特别是治疗与晚期癌症相关的先天难治性疼痛，其中治疗独立于晚期癌症的降低 肿瘤。 该抗氧化蛋白质优选从蛇形龙胆（Crotalus durissus terrificus）中获得，并且鼠尾草毒素是从响尾蛇（Crotalus scutulatus scutulatus）获得的。 优选地，组合物还包含有效量的乙酰水杨酸，由此毒素和乙酰水杨酸一起产生协同效应，提供增强的疼痛缓解。 本发明的组合物可以肠胃外（腹膜内）（静脉内，肌内或皮下）应用递送。 或者，组合物可以作为局部应用施用。 组合物的生物活性的特征在于其与突触前和突触后受体位点结合的能力。 这导致乙酰胆碱释放和活性的抑制。