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公开(公告)号:US20070117839A1
公开(公告)日:2007-05-24
申请号:US11594150
申请日:2006-11-08
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Mamoru Takaishi , Koichi Ito , Toshihiko Kaneko , Takeo Sasaki , Takehiko Miyagawa , Hiroaki Hagiwara , Yu Yoshida
IPC分类号: C07D455/02 , A61K31/4745
CPC分类号: C07D471/04 , C07D487/04
摘要: The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): wherein represents a single bond or a double bond; Ar1 represents a phenyl group or pyridinyl group that may be substituted with 1 to 3 substituents; R1 and R2 each represent a C1-6 alkyl group, a hydroxyl group, or the like; Z1 represents a methylene group or vinylene group, which may be substituted with 1 or 2 substituents selected from Substituent Group A1, an oxygen atom, or an imino group that may be substituted with a substituent selected from Substituent Group A1; and p, q, and r each represent an integer of 0 to 2, which has an effect of reducing Aβ40 and Aβ42 production, and thus is particularly useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ such as Alzheimer's disease or Down's syndrome.
摘要翻译: 本发明涉及一种新型的两种环状肉桂酰胺化合物和包含该化合物作为活性成分的药剂。 由通式(I)表示的两种环状肉桂酰胺化合物:其中表示单键或双键; Ar 1代表可被1至3个取代基取代的苯基或吡啶基; R 1和R 2各自表示C 1-6烷基,羟基等; Z 1表示亚甲基或亚乙烯基,其可以被1或2个选自取代基组A1,氧原子或亚氨基的取代基取代,所述取代基可以被选自取代基 A1组; 并且p,q和r各自表示0〜2的整数,其具有降低Abeta40和Abeta42产生的作用,因此特别可用作由Abeta如阿尔茨海默病或阿尔茨海默病引起的神经变性疾病的预防或治疗剂 唐氏综合症。
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公开(公告)号:US20110086860A1
公开(公告)日:2011-04-14
申请号:US12974447
申请日:2010-12-21
申请人: Teiji KIMURA , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人: Teiji KIMURA , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号: A61K31/497 , C07D233/54 , C07D403/10 , C07D401/04 , C07D241/00 , A61K31/4164 , A61K31/4178 , A61K31/454 , A61P25/28
CPC分类号: C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要: A compound represented by Formula (I) is provided: wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc., which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group which may be substituted, or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.
摘要翻译: 提供由式(I)表示的化合物:其中Ar 1表示可被1至3个取代基取代的咪唑基; Ar2表示可被1〜3个取代基取代的苯基; X1表示(1)-C≡C-或(2)双键等,其可以被取代; R1和R2表示例如可被取代的C1-6烷基或其药理学上可接受的盐及其作为药剂的用途。
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公开(公告)号:US07880009B2
公开(公告)日:2011-02-01
申请号:US11596723
申请日:2005-05-25
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号: C07D405/00 , A61K31/445
CPC分类号: C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中Ar 1表示可被1〜3个取代基取代的咪唑基; Ar 2表示吡啶基,嘧啶基或可被 1〜3个取代基; X1表示(1)-C≡C-或(2)可被取代的双键等; R 1和R 2表示例如C 1-6烷基或C 3-8环烷基, 可以被取代)或其药理学上可接受的盐及其作为药剂的用途。
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公开(公告)号:US20060004013A1
公开(公告)日:2006-01-05
申请号:US11136355
申请日:2005-05-25
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Takeo Sasaki , Hiroaki Hagiwara
IPC分类号: A61K31/498 , A61K31/4745 , A61K31/46
CPC分类号: C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.
摘要翻译: 本发明涉及由式(I)表示的化合物:(其中Ar 1代表可被1至3个取代基取代的咪唑基; Ar 2表示 吡啶基,嘧啶基或可被1至3个取代基取代的苯基; X 1表示(1)-C≡C-或(2)双键等,其可以 被取代; R 1和R 2表示例如可以被取代的C 1-6烷基或C 3-8环烷基)或其药理学上可接受的盐 以及作为药剂的用途。 本发明的目的是找到由Abeta引起的疾病的治疗或预防剂。 根据本发明,可以提供由Abeta引起的疾病的治疗或预防剂。
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公开(公告)号:US07667041B2
公开(公告)日:2010-02-23
申请号:US11136355
申请日:2005-05-25
申请人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Hiroaki Hagiwara
发明人: Teiji Kimura , Koki Kawano , Eriko Doi , Noritaka Kitazawa , Kogyoku Shin , Takehiko Miyagawa , Toshihiko Kaneko , Koichi Ito , Mamoru Takaishi , Hiroaki Hagiwara
IPC分类号: C07D401/00 , A61K31/54
CPC分类号: C07D401/10 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present invention relates to a compound represented by Formula (I): (wherein Ar1 represents an imidazolyl group which may be substituted with 1 to 3 substituents; Ar2 represents a pyridinyl group, a pyrimidinyl group, or a phenyl group which may be substituted with 1 to 3 substituents; X1 represents (1) —C≡C— or (2) a double bond etc. which may be substituted; R1 and R2 represent, for example, a C1-6 alkyl group or C3-8 cycloalkyl group which may be substituted) or a pharmacologically acceptable salt thereof and to the use thereof as pharmaceutical agents. The object of the present invention is to find a therapeutic or preventive agent for diseases caused by Aβ. According to the present invention, a therapeutic or preventive agents for diseases caused by Aβ can be provided.
摘要翻译: 本发明涉及由式(I)表示的化合物:其中Ar 1表示可被1〜3个取代基取代的咪唑基; Ar 2表示吡啶基,嘧啶基或可被 1〜3个取代基; X1表示(1)-C≡C-或(2)可被取代的双键等; R 1和R 2表示例如C 1-6烷基或C 3-8环烷基, 可以被取代)或其药理学上可接受的盐及其作为药剂的用途。 本发明的目的是找到由A&Bgr引起的疾病的治疗或预防剂。 根据本发明,由A&Bgr引起的疾病的治疗或预防剂; 可以提供。
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公开(公告)号:US07985702B2
公开(公告)日:2011-07-26
申请号:US12746384
申请日:2008-10-16
申请人: Kenichiro Kano , Takashi Tsuruta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
发明人: Kenichiro Kano , Takashi Tsuruta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
IPC分类号: B32B27/34
CPC分类号: B60R21/235 , B60R2021/23514 , D03D1/02 , D03D15/0088 , D06M15/263 , D06M15/507 , D06M15/568 , D06M15/59 , D06N3/0002 , D06N3/042 , D06N3/121 , D06N3/125 , D06N3/14 , Y10T428/24612 , Y10T442/2139 , Y10T442/2811
摘要: A woven fabric for an airbag includes a synthetic fiber woven fabric having a cover factor of 2000 to 2500 in which at least one side thereof is coated with a synthetic resin. Air permeability of the woven fabric under a pressure difference of 100 kPa is 0.01 to 1.00 L/cm2/min. A resin film is present at an upper part of a single yarn at a thickness of 2 μm or less on a central cross section of a weaving yarn part. A resin film is present at an upper part of a single yarn at a thickness of 2 to 30 μm on a cross section at a border between weaving yarn parts. The synthetic resin can be a polyamide-based resin that includes a polyether compound of a number average molecular weight of 100 to 5000 as a soft segment.
摘要翻译: 一种用于气囊的机织织物包括具有2000至2500的覆盖系数的合成纤维织物,其中至少一侧涂覆有合成树脂。 在100kPa的压力差下,织物的透气度为0.01〜1.00L / cm 2 /分钟。 在织造纱线部分的中心横截面处,在单根纱线的上部以2μm以下的厚度存在树脂膜。 在织造纱线部分之间的边界处的横截面上,在单纱的上部存在2〜30μm的树脂膜。 合成树脂可以是包含作为软链段的数均分子量为100〜5000的聚醚化合物的聚酰胺类树脂。
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公开(公告)号:US20100282358A1
公开(公告)日:2010-11-11
申请号:US12746389
申请日:2008-10-16
申请人: Kenichiro Kano , Takashi Tsuruta , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
发明人: Kenichiro Kano , Takashi Tsuruta , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
IPC分类号: D03D1/02 , B60R21/16 , D06M15/693
CPC分类号: B60R21/235 , B60R2021/23514 , D03D1/02 , D06M15/59 , D06N3/0002 , D06N3/125 , Y10T442/2139 , Y10T442/2811
摘要: An object of the present invention is to provide a fabric for an airbag which is of low cost, is excellent in accommodability, and has air permeability satisfying the human body initial constraining performance.The present invention provides a fabric for an airbag comprising a synthetic fiber woven fabric in which at least one side thereof is coated with a synthetic resin, characterized in that a range of 0.1 to 10 g/m2 of a synthetic resin is adhered to the synthetic fiber woven fabric having a cover factor represented by the equation 1 of less than 2000 and FR represented by the equation 2 of 55% or more, and air permeability of the fabric under a pressure difference of 100 kPa after adhesion is 0.01 to 1.00 L/cm2/min.
摘要翻译: 本发明的目的在于提供一种低成本,优良的适应性,并具有满足人体初始约束性能的透气性的气囊用织物。 本发明提供了一种用于气囊的织物,其包括合成纤维织物,其中至少一侧涂覆有合成树脂,其特征在于,将合成树脂的0.1至10g / m 2的范围粘附到合成树脂 具有小于2000的等式1表示的覆盖系数的纤维编织物,等式2表示的FR为55%以上,粘合后的压力差为100kPa的织物的透气性为0.01〜1.00L / cm2 / min。
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公开(公告)号:US20110097955A1
公开(公告)日:2011-04-28
申请号:US12981372
申请日:2010-12-29
申请人: Kenichiro Kano , Takashi Tsuruta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
发明人: Kenichiro Kano , Takashi Tsuruta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
IPC分类号: B32B5/24
CPC分类号: B60R21/235 , B60R2021/23514 , D03D1/02 , D03D15/0088 , D06M15/263 , D06M15/507 , D06M15/568 , D06M15/59 , D06N3/0002 , D06N3/042 , D06N3/121 , D06N3/125 , D06N3/14 , Y10T428/24612 , Y10T442/2139 , Y10T442/2811
摘要: An object of the present invention is to provide a woven fabric for an airbag which is of low cost, is excellent in accommodability, and has air permeability satisfying the human body initial constraining performance.The present invention provides a woven fabric for an airbag comprising a synthetic fiber woven fabric having a cover factor represented by the equation 1 of 2000 to 2500 in which at least one side thereof is coated with a synthetic resin, wherein air permeability of the woven fabric under a pressure difference of 100 kPa is 0.01 to 1.00 L/cm2/min, and a resin film is present at an upper part of a single yarn at a thickness of 2 μm or less on a central cross section of a weaving yarn part, while a resin film is present at an upper part of a single yarn at a thickness of 2 to 30 μm on a cross section at a border between weaving yarn parts.
摘要翻译: 本发明的目的是提供一种低成本,优良的适应性的气囊用织物,并且具有满足人体初始约束性能的透气性。 本发明提供一种用于气囊的机织织物,其包括合成纤维织物,其具有由2000至2500的等式1表示的覆盖系数,其中至少一侧涂覆有合成树脂,其中织物的透气性 在100kPa的压力差为0.01〜1.00L / cm 2 / min的范围内,在织造纱部的中央截面为2μm以下的单纱的上部存在树脂膜, 而在编织纱线部分之间的边界处的横截面上,单根纱线的上部存在树脂膜,厚度为2〜30μm。
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公开(公告)号:US20110014833A1
公开(公告)日:2011-01-20
申请号:US12935146
申请日:2008-10-16
CPC分类号: D06M15/59 , B60R2021/23514 , C08G69/40 , C08J5/04 , C08J2377/06 , C09D177/06 , D06N3/125 , Y10T442/20 , Y10T442/2139 , Y10T442/2811
摘要: An object of the present invention is to provide a copolymerized polyether polyamide resin for coating on or for impregnation to a woven or knitted fabric, which resin further enhances slippage resistance and tear strength affecting the developing property of an airbag which is one of the automobile safety parts, as compared with those in the prior art.According to the present invention, a copolymerized polyether polyamide resin for coating on or for impregnation to a woven or knitted fabric is provided, characterized in that, elongation and elastic modulus of the copolymerized polyether polyamide resin are not less than 1000% and not more than 15 MPa, respectively. The copolymerized polyether polyamide resin has a constitution wherein said copolymerized polyether polyamide resin is such that wherein a soft segment comprising a polyether polyamide constituted from a polyether diamine compound and a dicarboxylic acid compound is bonded to a hard segment comprising a polyamide constituted from an aminocarboxylic acid compound and/or a lactam compound.
摘要翻译: 本发明的目的是提供一种用于在机织或针织物上涂布或浸渍的共聚聚醚聚酰胺树脂,该树脂进一步增强了影响作为汽车安全性之一的气囊的显影性能的抗滑性和撕裂强度 部件,与现有技术相比。 根据本发明,提供了用于在机织或针织物上涂布或浸渍于机织或针织织物中的共聚聚醚聚酰胺树脂,其特征在于共聚聚醚聚酰胺树脂的伸长率和弹性模量不小于1000%且不大于 15 MPa。 共聚聚醚聚酰胺树脂具有这样的结构,其中所述共聚聚醚聚酰胺树脂是这样的,其中包含由聚醚二胺化合物和二羧酸化合物构成的聚醚聚酰胺的软链段结合到包含由氨基羧酸 化合物和/或内酰胺化合物。
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公开(公告)号:US20100260976A1
公开(公告)日:2010-10-14
申请号:US12746384
申请日:2008-10-16
申请人: Kenichiro Kano , Takashi Tsunuta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
发明人: Kenichiro Kano , Takashi Tsunuta , Mamoru Kitamura , Hideo Isoda , Hiroaki Hagiwara , Gaku Maruyama , Takahiro Hattori
IPC分类号: D06M15/693 , D03D1/02 , B32B27/02
CPC分类号: B60R21/235 , B60R2021/23514 , D03D1/02 , D03D15/0088 , D06M15/263 , D06M15/507 , D06M15/568 , D06M15/59 , D06N3/0002 , D06N3/042 , D06N3/121 , D06N3/125 , D06N3/14 , Y10T428/24612 , Y10T442/2139 , Y10T442/2811
摘要: An object of the present invention is to provide a woven fabric for an airbag which is of low cost, is excellent in accommodability, and has air permeability satisfying the human body initial constraining performance.The present invention provides a woven fabric for an airbag comprising a synthetic fiber woven fabric having a cover factor represented by the equation 1 of 2000 to 2500 in which at least one side thereof is coated with a synthetic resin, wherein air permeability of the woven fabric under a pressure difference of 100 kPa is 0.01 to 1.00 L/cm2/min, and a resin film is present at an upper part of a single yarn at a thickness of 2 μm or less on a central cross section of a weaving yarn part, while a resin film is present at an upper part of a single yarn at a thickness of 2 to 30 μm on a cross section at a border between weaving yarn parts.
摘要翻译: 本发明的目的是提供一种低成本,优良的适应性的气囊用织物,并且具有满足人体初始约束性能的透气性。 本发明提供一种用于气囊的机织织物,其包括合成纤维织物,其具有由2000至2500的等式1表示的覆盖系数,其中至少一侧涂覆有合成树脂,其中织物的透气性 在100kPa的压力差为0.01〜1.00L / cm 2 / min的范围内,在织造纱部的中央截面为2μm以下的单纱的上部存在树脂膜, 而在编织纱线部分之间的边界处的横截面上,单根纱线的上部存在树脂膜,厚度为2〜30μm。
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