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53 条记录 (耗时 0.056 秒)

    Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
    21.
    发明授权
    Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity 失效
    具有乙酰胆碱酯酶抑制和毒蕈碱激动剂活性的恶二唑衍生物

    公开(公告)号：US5622976A

    公开(公告)日：1997-04-22

    申请号：US244904

    申请日：1994-06-24

    申请人： Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    发明人： Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    IPC分类号： A61K31/41 ,  A61K31/4245 ,  A61K31/445 ,  A61P25/28 ,  A61P27/16 ,  A61P43/00 ,  C07D271/06 ,  C07D271/10 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02

    CPC分类号： C07D271/06 ,  C07D413/10 ,  C07D413/14 ,  C07D453/02 ,  Y02P20/55

    摘要： Heterocyclic compounds of the formula:R.sup.1 --Q--Z--X--A--MwhereinR.sup.1 is lower alkyl, a heterocyclic group which may have suitable substituent(s), etc;Q is oxadiazolediyl,Z is bond or vinyl,X is bond,a group of the formula: ##STR1## (in which R.sup.4 is hydrogen or lower alkyl), a group of the formula: ##STR2## (in which R.sup.8 is hydroxy or protected hydroxy), etc; A is bond, lower alkylene or lower alkynylene andM is a heterocyclic group containing at least one nitrogen atom which may have one substituent selected from the group consisting of lower alkyl, an imino protective group and ar(lower)alkyl which may have suitable substituent(s),and a pharmaceutically acceptable salt thereof which are useful as a medicament.

    摘要翻译： PCT No.PCT / JP92 / 01658 Sec。 371日期：1994年6月24日 102（e）1994年6月24日PCT提交1992年12月18日PCT公布。 公开号WO93 / 13083 日期：1993年7月8日式：R1-Q-Z-X-A-M的杂环化合物，其中R 1为低级烷基，可具有合适取代基的杂环基等; Q是恶二唑二基，Z是键或乙烯基，X是键，下式的基团：其中R 4是氢或低级烷基，下式的基团：其中R 8是羟基或 保护羟基）等; A是键，低级亚烷基或低级亚炔基，M是含有至少一个氮原子的杂环基，其可以具有选自低级烷基，亚氨基保护基和可具有合适取代基的芳基（低级）烷基的一个取代基 和其药学上可接受的盐，其可用作药物。

    Bicyclic amine compound and a process for the preparation thereof
    22.
    发明授权
    Bicyclic amine compound and a process for the preparation thereof 失效
    双环胺化合物及其制备方法

    公开(公告)号：US5059608A

    公开(公告)日：1991-10-22

    申请号：US327813

    申请日：1989-03-23

    申请人： Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    发明人： Hisashi Takasugi ,  Atsushi Kuno ,  Mitsuru Ohkubo

    IPC分类号： A61K31/47 ,  A61K31/472 ,  A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/10 ,  C07D217/14 ,  C07D217/16 ,  C07D223/16 ,  C07D401/06 ,  C07D405/04 ,  C07D409/04

    CPC分类号： C07D223/16 ,  C07D217/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/14 ,  C07D217/16 ,  C07D405/04 ,  C07D409/04 ,  Y02P20/55

    摘要： The invention relates to a compound useful as an anticonvulsant, and for treatment of delayed neuronal death, the compound being a bicyclic amine of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.2 is aryl which may have one or more suitable substituent(s), cyclo(lower)alkyl or heterocyclic group,R.sup.3 is hydrogen, lower alkyl which may have one or more suitable substituent(s), lower alkenyl, or acyl which may have one or more suitable substituent(s),R.sup.4 is hydrogen, lower alkyl, or hydroxy(lower)alkyl,R.sup.5 is hydrogen, lower alkyl, halogen, or protected amino, andn is an integer of 1 or 2, with the proviso that when R.sup.3 is lower alkyl which may have one or more suitable substituent(s), R.sup.2 is cyclo(lower)alkyl or heterocyclic group,or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及可用作抗惊厥药并用于治疗延迟性神经元死亡的化合物，该化合物为下式的双环胺：其中R 1为低级烷基，R 2为可具有一个或多个合适取代基的芳基（ s），环（低级）烷基或杂环基，R 3是氢，可具有一个或多个合适取代基的低级烷基，可具有一个或多个合适取代基的低级烯基或酰基，R 4是氢 ，低级烷基或羟基（低级）烷基，R 5为氢，低级烷基，卤素或被保护的氨基，n为1或2的整数，条件是当R 3为低级烷基时，其可具有一个或多个合适的 取代基，R2是环（低级）烷基或杂环基，或其药学上可接受的盐。

    Indolopyrrolocarbazole derivatives and antitumor agents
    29.
    发明授权
    Indolopyrrolocarbazole derivatives and antitumor agents 失效
    吲哚吡咯咔唑衍生物和抗肿瘤剂

    公开(公告)号：US06703373B1

    公开(公告)日：2004-03-09

    申请号：US10070825

    申请日：2002-03-11

    申请人： Katsuhisa Kojiri ,  Hisao Kondo ,  Hiroharu Arakawa ,  Mitsuru Ohkubo ,  Hiroyuki Suda

    发明人： Katsuhisa Kojiri ,  Hisao Kondo ,  Hiroharu Arakawa ,  Mitsuru Ohkubo ,  Hiroyuki Suda

    IPC分类号： A01N4304

    CPC分类号： C07H19/00 ,  C07H15/00 ,  C07H19/22

    摘要： A compound represented by the formula or a pharmaceutically acceptable salt thereof wherein R represents an unsubstituted pyridyl, furyl or thienyl group, or a pyridyl, furyl or thienyl group each of which has one or more substituents selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group except that when the pyridyl, furyl or thienyl group has a lower alkoxy group as a substituent, each of which simultaneously has another substituent selected from the group consisting of a hydroxyl group, a lower alkoxy group, a hydroxy lower alkyl group and a hydroxy lower alkenyl group, m represents an integer of 1 to 3, and G represents a &bgr;-D-glucopyranosyl group, and the positions of substitution of the hydroxyl groups on the indolopyrrolocarbazole ring are the 1- and 11-positions, or the 2- and 10-positions, and an antitumore agent containing it as an effective ingredient. The compounds have a better antitumor action than known compounds having a similar structure.

    摘要翻译： 由下式表示的化合物或其药学上可接受的盐，其中R表示未取代的吡啶基，呋喃基或噻吩基，或吡啶基，呋喃基或噻吩基，其各自具有一个或多个选自羟基， 低级烷氧基，羟基低级烷基和羟基低级烯基，不同之处在于当吡啶基，呋喃基或噻吩基具有低级烷氧基作为取代基时，其各自同时具有选自羟基的另一取代基 ，低级烷氧基，羟基低级烷基和羟基低级烯基，m表示1〜3的整数，G表示β-D-吡喃葡萄糖基，吲哚并吡咯并唑的羟基取代位置 环是1-和11位，或2-和10-位，以及含有它作为有效成分的抗肿瘤剂。化合物具有更好的抗肿瘤 比已知具有相似结构的化合物。

    Solar battery
    30.
    发明授权
    Solar battery 有权
    太阳能电池

    公开(公告)号：US06610919B2

    公开(公告)日：2003-08-26

    申请号：US10204847

    申请日：2002-08-26

    申请人： Mitsuru Ohkubo

    发明人： Mitsuru Ohkubo

    IPC分类号： H01L3118

    CPC分类号： H01L31/0508 ,  B64G1/443 ,  H01L27/1421 ,  Y02E10/50 ,  Y10S136/293

    摘要： A diode-incorporated solar battery, which is intended to minimize an increase in production cost and a decrease in reliability that are involved in incorporating diodes into the solar battery, and to reduce the area of the surface electrodes of the solar battery so as to increase the electric power generation of the solar battery, wherein to this end, a connecting metal fixture for interconnecting solar cells has added thereto projection for parallel-connecting the solar cells and diodes.

    摘要翻译： 一种二极管并入的太阳能电池，旨在最小化生产成本的增加和降低太阳能电池中二极管的可靠性，并减少太阳能电池的表面电极的面积，以增加 太阳能电池的发电，其中为此，用于互连太阳能电池的连接金属夹具已经添加了用于并联连接太阳能电池和二极管的突起。