公开(公告)号：US20240075193A1

公开(公告)日：2024-03-07

申请号：US18143005

申请日：2023-05-03

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Rishi Kant ,  Andrew Posselt ,  Shang Song ,  Willieford Moses ,  Charles Blaha

IPC: A61M1/16 ,  A61B5/15 ,  A61M1/36 ,  B01D61/14 ,  B01D63/08 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/02

CPC classification number: A61M1/1678 ,  A61B5/150992 ,  A61M1/3689 ,  B01D61/145 ,  B01D63/08 ,  B01D67/0037 ,  B01D67/0072 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/027 ,  B01D71/70 ,  B01D2325/021

Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

公开(公告)号：US11712663B2

公开(公告)日：2023-08-01

申请号：US17456344

申请日：2021-11-23

Applicant: The Regents of the University of California

Inventor： Shuvo Roy

IPC: B01D63/08 ,  B01D61/28 ,  B01D71/02 ,  A61M1/16 ,  A61M1/36 ,  B01D61/24

CPC classification number: B01D63/085 ,  A61M1/1631 ,  A61M1/3655 ,  B01D61/243 ,  B01D61/28 ,  B01D63/084 ,  B01D71/02 ,  A61M2205/04 ,  A61M2205/75 ,  A61M2207/00 ,  B01D2325/04

Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

公开(公告)号：US11666691B2

公开(公告)日：2023-06-06

申请号：US17343361

申请日：2021-06-09

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Rishi Kant ,  Andrew Posselt ,  Shang Song ,  Willieford Moses ,  Charles Blaha

IPC: A61M1/16 ,  B01D63/08 ,  B01D67/00 ,  B01D69/02 ,  B01D69/12 ,  B01D71/02 ,  A61M1/36 ,  B01D69/08 ,  A61B5/15 ,  B01D61/14 ,  B01D71/70 ,  B01D69/14

CPC classification number: A61M1/1678 ,  A61B5/150992 ,  A61M1/3689 ,  B01D61/145 ,  B01D63/08 ,  B01D67/0037 ,  B01D67/0072 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/027 ,  A61M2202/09 ,  A61M2205/04 ,  B01D69/145 ,  B01D71/024 ,  B01D71/70 ,  B01D2325/021

Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

公开(公告)号：US11413383B2

公开(公告)日：2022-08-16

申请号：US17092616

申请日：2020-11-09

Applicant: The Regents of the University of California

Inventor： Rishi Kant ,  Shuvo Roy ,  Benjamin W. Chui ,  Kenneth G. Goldman

IPC: A61M1/16 ,  B01D39/16 ,  B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  B01D61/14 ,  B01D63/08 ,  B01D69/06 ,  C23F1/00 ,  B01D61/02 ,  B01D61/24

Abstract: The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.

公开(公告)号：US11033668B2

公开(公告)日：2021-06-15

申请号：US16082501

申请日：2017-03-07

Applicant: The Regents of the University of California

Inventor： Shuvo Roy ,  Rishi Kant ,  Andrew Posselt ,  Shang Song ,  Willieford Moses ,  Charles Blaha

IPC: A61M1/16 ,  B01D63/08 ,  B01D67/00 ,  B01D69/02 ,  B01D69/12 ,  B01D71/02 ,  A61M1/36 ,  B01D69/08 ,  A61B5/15 ,  B01D61/14 ,  B01D71/70 ,  B01D69/14

Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

公开(公告)号：US10463293B2

公开(公告)日：2019-11-05

申请号：US15379220

申请日：2016-12-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Michel Maharbiz ,  Vivek Subramanian ,  Ana Claudia Arias ,  Sarah Swisher ,  Amy Liao ,  Monica Lin ,  Felippe Pavinatto ,  Yasser Khan ,  Daniel Cohen ,  Elisabeth Leeflang ,  Shuvo Roy ,  Michael Harrison ,  David Young

IPC: A61B5/00 ,  A61B5/053

Abstract: Methods and apparatus for real-time, quantifiable monitoring of high-risk areas of biological tissue are described. The methods and apparatus use impedance spectroscopy to detect subtle changes in tissue health.

公开(公告)号：US20190134568A1

公开(公告)日：2019-05-09

申请号：US16098708

申请日：2017-05-02

Applicant: The Regents of the University of California

Inventor： Shuvo Roy

IPC: B01D63/08 ,  B01D61/28 ,  B01D61/24 ,  B01D71/02 ,  A61M1/16 ,  A61M1/36

Abstract: Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.