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公开(公告)号：US20230098681A1
公开(公告)日：2023-03-30
申请号：US17956236
申请日：2022-09-29
Inventor： Landon D. Nash , Duncan J. Maitland , Nicole Docherty , Thomas S. Wilson , Ward Small, IV , Jason Ortega , Pooja Singhal
IPC: C08J9/36 , B29C59/14 , B32B27/06 , B32B5/18 , A61L31/14 , A61L31/06 , A61L24/00 , A61L24/04 , B05D1/00 , B05D3/14 , B05D7/02
Abstract: An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
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公开(公告)号：US20230093592A1
公开(公告)日：2023-03-23
申请号：US17977345
申请日：2022-10-31
Inventor： Jennifer N. Rodriguez , Duncan J. Maitland , Thomas S. Wilson
IPC: B29C44/56 , C08J9/38 , A61L31/06 , A61L31/14 , C08G18/73 , B32B5/18 , B32B5/32 , C08G18/32 , C08L75/04
Abstract: Polymeric based closed cell foams, such as shape memory polymer foams, contain bubbles. Making these bubbles continuous is called reticulation. Disclosed are embodiments of a device and method to controllably reticulate polymer-based closed cell foams by puncturing the membranes of these polymer-based closed cell foams.
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公开(公告)号：US11369720B2
公开(公告)日：2022-06-28
申请号：US16777190
申请日：2020-01-30
Applicant: The Texas A&M University System
Inventor： Rachael Muschalek , Keith Hearon , Landon D. Nash , Duncan J. Maitland
Abstract: An embodiment includes a system comprising: a substrate of a medical device; an un-foamed polyurethane coating directly contacting the substrate and fixedly attached to the substrate; a thermoset polyurethane shape memory polymer (SMP) foam, having first and second states, which directly contacts the polyurethane coating and fixedly attaches to the polyurethane coating; wherein the polyurethane coating fixedly attaches the SMP foam to the substrate. Other embodiments are described herein.
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公开(公告)号：US20210393849A1
公开(公告)日：2021-12-23
申请号：US17306482
申请日：2021-05-03
Inventor： Duncan J. Maitland , Thomas S. Wilson
Abstract: Implant devices and structures that reduce inflammation and promote healing of the area of implant. Specifically, the use of shape memory open cell biocompatible polymer foams for implants that assist in and promote healing and especially in filling and sealing aneurisms.
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公开(公告)号：US11141164B2
公开(公告)日：2021-10-12
申请号：US15599133
申请日：2017-05-18
Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , The Texas A&M University System , Jonathan Hartman
Inventor： Jason M. Ortega , William J. Benett , Ward Small , Thomas S. Wilson , Duncan J. Maitland , Jonathan Hartman
Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.
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Patent Agency Ranking
公开(公告)号：US11090408B2
公开(公告)日：2021-08-17
申请号：US16466073
申请日：2017-12-06
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mary Beth Monroe , Duncan J. Maitland , Andrew Weems , Brandis Keller , Grace Fletcher
IPC: A61L24/00 , A61L24/04 , C08G18/10 , C08G18/73 , C08G18/83 , C08J9/36 , A61L15/26 , A61L27/50 , A61L31/14 , A61L31/16 , A61L15/46 , A61L27/18 , A61L27/56 , A61L15/42 , A61L31/06 , A61L27/54
Abstract: An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.
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公开(公告)号：US10786261B2
公开(公告)日：2020-09-29
申请号：US15754330
申请日：2016-09-02
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Duncan J. Maitland , Todd L. Landsman , Jennifer N. Rodriguez , Anthony J. Boyle , Alan C. Glowczwski , Mark A. Wierzbicki
Abstract: An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit.
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公开(公告)号：US10548608B2
公开(公告)日：2020-02-04
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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公开(公告)号：US20190282726A1
公开(公告)日：2019-09-19
申请号：US16466073
申请日：2017-12-06
Applicant: THE TEXAS A&M UNIVERSITY SYSTEM
Inventor： Mary Beth Monroe , Duncan J. Maitland , Andrew Weems , Brandis Keller , Grace Fletcher
Abstract: An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.
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30.发明申请公开(公告)号：US20180177508A1
公开(公告)日：2018-06-28
申请号：US15579217
申请日：2016-06-07
Inventor： Anthony J. Boyle , Keith Hearon , Duncan J. Maitland , Landon D. Nash , Thomas S. Wilson
CPC classification number: A61B17/12181 , A61B17/12031 , A61B17/12113 , A61B17/1219 , A61B2017/00871 , A61B2017/00938 , A61B2017/00964 , A61L31/06 , A61L31/14 , A61L31/146 , A61L2400/16 , A61L2430/36 , C08L75/04
Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents. This selective solvent actuation can be used to increase working time of a SMP foam device, that is, the time allowed for use of a device without undesired actuation, while maintaining functional SMP actuation. Solvent actuated SMP foams can be used in various applications including, but not limited to, treatment of aneurysms and arterio-venous malformations, tissue engineering, and wound healing.
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