公开(公告)号：US07980699B2

公开(公告)日：2011-07-19

申请号：US12418841

申请日：2009-04-06

申请人： Daniel R. Neal ,  Leander Zickler

发明人： Daniel R. Neal ,  Leander Zickler

IPC分类号： A61B3/00 ,  A61B3/10

CPC分类号： G06T5/50 ,  A61F9/00804 ,  A61F9/00827 ,  A61F2009/00848 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882 ,  G06T7/33 ,  G06T2207/20221 ,  G06T2207/30041

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。 例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的 尝试在完全相同的时间获取图像或其他数据。 有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化 等）。

公开(公告)号：US20090284753A1

公开(公告)日：2009-11-19

申请号：US12474607

申请日：2009-05-29

申请人： Daniel R. Neal ,  Richard James Copland ,  David A. Neal

发明人： Daniel R. Neal ,  Richard James Copland ,  David A. Neal

IPC分类号： G01B11/24

CPC分类号： G01J9/00 ,  G01B11/306 ,  G01M11/0257

摘要： A system for mapping a three-dimensional structure includes a projecting optical system adapted to project light onto an object, a correction system adapted to compensate the light for at least one aberration in the object, an imaging system adapted to collect light scattered by the object and a wavefront sensor adapted to receive the light collected by the imaging system and to sense a wavefront of the received light. For highly aberrated structures, a number of wavefront measurements are made which are valid over different portions of the structure, and the valid wavefront data is stitched together to yield a characterization of the total structure.

摘要翻译： 一种用于映射三维结构的系统包括：投影光学系统，其适于将光投射到物体上;校正系统，其适于补偿所述光在所述物体中的至少一个像差;适于收集由所述物体散射的光的成像系统 以及波前传感器，其适于接收由成像系统收集的光并且感测所接收的光的波前。 对于高像差结构，进行了许多波前测量，其在结构的不同部分是有效的，并且有效的波前数据被缝合在一起以产生总结构的表征。

公开(公告)号：US07616330B2

公开(公告)日：2009-11-10

申请号：US11783316

申请日：2007-04-09

申请人： Daniel R. Neal ,  Thomas Daniel Raymond ,  William Shea Powers

发明人： Daniel R. Neal ,  Thomas Daniel Raymond ,  William Shea Powers

IPC分类号： G01B11/14 ,  G01B11/24

CPC分类号： G01B11/24 ,  A61B3/1005 ,  A61B3/107 ,  G01J9/00 ,  G01J9/02 ,  G01M11/0271

摘要： A geometric measurement system is adapted to precisely measure one or more surfaces of objects such as corneas, molds, contact lenses in molds, contact lenses, or other objects in a fixture. The geometric measurement system can employ one or more of three possible methods of measurement: Shack-Hartmann wavefront sensing with wavefront stitching; phase diversity sensing; and white light interferometry.

摘要翻译： 几何测量系统适于精确测量物体的一个或多个表面，例如角膜，模具，模具中的隐形眼镜，隐形眼镜或固定装置中的其它物体。 几何测量系统可以采用三种可能的测量方法中的一种或多种：具有波前缝合的Shack-Hartmann波前感测; 相位分集感测; 和白光干涉测量。

公开(公告)号：US06908196B2

公开(公告)日：2005-06-21

申请号：US10369513

申请日：2003-02-21

申请人： Satish Venkatesh Herekar ,  Daniel R. Neal ,  Richard James Copland ,  David Neal

发明人： Satish Venkatesh Herekar ,  Daniel R. Neal ,  Richard James Copland ,  David Neal

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/103 ,  A61B17/00 ,  A61B18/18 ,  A61B18/20 ,  A61F20060101 ,  A61F9/01

CPC分类号： A61F9/00821 ,  A61B18/20 ,  A61B2017/00057 ,  A61B2018/00636 ,  A61F2009/00848 ,  A61F2009/00853 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088

摘要： A real-time refractory control system includes a laser refractive surgery instrument for modifying the refraction of the eye, an objective diagnostic apparatus for measuring the refraction and aberrations of the eye, and an aperture-sharing element to inject a refractive surgery beam and a monitoring diagnostic beam. An associated method of adjusting a refraction of an eye, includes: performing a procedure to modify the refraction of the eye; while the procedure is being performed, measuring the refraction and/or an aberration of the eye; and terminating the procedure when a change in the measured refraction and/or the measured aberration reaches a desired value.

摘要翻译： 实时耐火材料控制系统包括用于修改眼睛折射的激光屈光手术器具，用于测量眼睛的折射和像差的客观诊断装置，以及用于注射屈光手术束的孔径共享元件和监视 诊断光束。 调整眼睛折射的相关联的方法包括：执行改变眼睛折射的过程; 同时执行该过程，测量眼睛的折射和/或像差; 并且当测量的折射和/或测量的像差的变化达到期望值时，终止该过程。

公开(公告)号：US06864043B2

公开(公告)日：2005-03-08

申请号：US10673569

申请日：2003-09-30

申请人： Daniel R. Neal ,  Justin D. Mansell

发明人： Daniel R. Neal ,  Justin D. Mansell

IPC分类号： G01J9/00 ,  G02B3/00 ,  G02B27/58 ,  G03F7/00

CPC分类号： G02B3/0056 ,  G01J9/00 ,  G02B3/0012 ,  G02B27/58

摘要： An optical element which controls both the phase and irradiance distribution, thereby completely specifying the E-field, of light, allowing completely arbitrary control of the light at any plane. Such an optical element includes a portion that controls the phase and a portion that controls the irradiance. The portion that controls the irradiance is an apodized irradiance mask having its transmission varying with position in a controlled fashion. This apodized irradiance mask is preferably a pattern of metal. In order to insure a smoothly varying pattern of metal with minimized diffraction effects, a very thin mask spaced from a substrate is used to provide the metal on the substrate. The apodized irradiance mask may be placed directly on the phase control portion, or may be on an opposite side of a substrate of the phase controlled portion.

摘要翻译： 控制相位和辐照度分布的光学元件，从而完全指定光的E场，允许在任何平面上完全任意地控制光。 这种光学元件包括控制相位的部分和控制辐照度的部分。 控制辐照度的部分是其变形的辐照度掩模，其传播以受控的方式随位置变化。 这个变迹的辐照度掩模优选为金属图案。 为了以最小的衍射效应确保金属的平滑变化的图案，使用与衬底间隔开的非常薄的掩模来在衬底上提供金属。 变迹的辐照度掩模可以直接放置在相位控制部分上，或者可以在相位控制部分的基板的相对侧上。

公开(公告)号：US06819413B2

公开(公告)日：2004-11-16

申请号：US10650666

申请日：2003-08-29

申请人： Daniel R. Neal ,  Richard J. Copland ,  Ron R. Rammage ,  Daniel M. Topa ,  Daniel R. Hamrick

发明人： Daniel R. Neal ,  Richard J. Copland ,  Ron R. Rammage ,  Daniel M. Topa ,  Daniel R. Hamrick

IPC分类号： G01J100

CPC分类号： G01M11/0257 ,  G01J9/00 ,  G02B7/28 ,  G02B27/30 ,  G02B27/50

摘要： An enhanced dynamic range wavefront sensing system includes a light source disposed on a first side of an optically transmissive device, a wavefront sensor disposed on a second side of an optically transmissive device, a relay imaging system disposed between the optically transmissive device and the wavefront sensor, and means for adjusting a distance between the light source and the optically transmissive device. Beneficially, the relay imaging system includes a range-limiting aperture to insure that the wavefront sensor never goes out of range so that a feedback system can be employed to move the light source one focal length away from the optically transmissive device.

摘要翻译： 增强型动态范围波前感测系统包括设置在光学透射装置的第一侧上的光源，设置在光学透射装置的第二侧上的波前传感器，设置在光学透射装置和波前传感器之间的中继成像系统 以及用于调节光源和光学透射装置之间的距离的装置。 有利的是，继电器成像系统包括范围限定孔径，以确保波前传感器永远不会超出范围，使得可以采用反馈系统将光源的一个焦距移动远离光学透射装置。

公开(公告)号：US06656373B1

公开(公告)日：2003-12-02

申请号：US09612223

申请日：2000-07-07

申请人： Daniel R. Neal ,  Justin D. Mansell

发明人： Daniel R. Neal ,  Justin D. Mansell

IPC分类号： B29D1100

CPC分类号： G02B3/0056 ,  G01J9/00 ,  G02B3/0012 ,  G02B27/58

摘要： An optical element which controls both the phase and irradiance distribution, thereby completely specifying the E-field, of light, allowing completely arbitrary control of the light at any plane. Such an optical element includes a portion that controls the phase and a portion that controls the irradiance. The portion that controls the irradiance is an apodized irradiance mask having its transmission varying with position in a controlled fashion. This apodized irradiance mask is preferably a pattern of metal. In order to insure a smoothly varying pattern of metal with minimized diffraction effects, a very thin mask spaced from a substrate is used to provide the metal on the substrate. The apodized irradiance mask may be placed directly on the phase control portion, or may be on an opposite side of a substrate of the phase controlled portion.

摘要翻译： 控制相位和辐照度分布的光学元件，从而完全指定光的E场，允许在任何平面上完全任意地控制光。 这种光学元件包括控制相位的部分和控制辐照度的部分。 控制辐照度的部分是其变形的辐照度掩模，其传播以受控的方式随位置变化。 这个变迹的辐照度掩模优选为金属图案。 为了以最小的衍射效应确保金属的平滑变化的图案，使用与衬底间隔开的非常薄的掩模来在衬底上提供金属。 变迹的辐照度掩模可以直接放置在相位控制部分上，或者可以在相位控制部分的基板的相对侧上。

公开(公告)号：US20210212601A1

公开(公告)日：2021-07-15

申请号：US17145335

申请日：2021-01-09

申请人： Daniel R. Neal ,  R James Copland

发明人： Daniel R. Neal ,  R James Copland

IPC分类号： A61B5/11 ,  A61B3/14 ,  A61B3/113 ,  A61B5/00

摘要： This invention, a Purkinjenator™ optical system, is an eye-tracker and methodology for tracking Purkinje reflection images from a human eye in real-time, which allows for the XYZ position and tip/tilt of structures inside the eye to be determined in real-time. When used in combination with programmable groups of IR LED light sources, unique patterns of Purkinje reflections from internal surfaces (and corneal surfaces) can be identified. Thus, XYZ positioning and tip/tilt of internal structures can be accurately and rapidly determined. An Optical Coherence Tomography (OCT) optical system can be combined with the Purkinjenator™ optical system to provide Z-axis distance information.

公开(公告)号：US20100045934A1

公开(公告)日：2010-02-25

申请号：US12611438

申请日：2009-11-03

申请人： Daniel R. Neal ,  Richard James Copland

发明人： Daniel R. Neal ,  Richard James Copland

IPC分类号： A61B3/103 ,  A61B3/10

CPC分类号： G01J9/00 ,  G01B11/306 ,  G01M11/0257

摘要： An ophthalmic error measurement system includes a projecting optical system delivering light onto a retina of an eye, a pre-correction system which compensates a light beam to be injected into the eye for aberrations in the eye, the pre-correction system being positioned in between the projecting optical system and the eye, an imaging system which collects light scattered by the retina, and a detector receiving light returned by the retina from the imaging system. Use of the pre-correction system allows the end-to-end aberrations of the ocular system to be analyzed. The use of a pre-correction system also allows use of a minimized spot size on the retina, and all of its attendant advantages.

摘要翻译： 一种眼科误差测量系统包括：将光传送到眼睛的视网膜上的投影光学系统;补偿被注入到眼睛中的光束以用于眼睛中的像差的预校正系统;预校正系统位于 投影光学系统和眼睛，收集由视网膜散射的光的成像系统和从成像系统接收由视网膜返回的光的检测器。 使用预校正系统可以对眼系统的端对端像差进行分析。 使用预校正系统还允许在视网膜上使用最小化的斑点尺寸以及其所有伴随的优点。

公开(公告)号：US20090316112A1

公开(公告)日：2009-12-24

申请号：US12418841

申请日：2009-04-06

申请人： Daniel R. Neal ,  Leander Zickler

发明人： Daniel R. Neal ,  Leander Zickler

IPC分类号： A61B3/11 ,  A61B3/10 ,  A61B3/107

CPC分类号： G06T5/50 ,  A61F9/00804 ,  A61F9/00827 ,  A61F2009/00848 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882 ,  G06T7/33 ,  G06T2207/20221 ,  G06T2207/30041

摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).

摘要翻译： 便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。 本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。 例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的 尝试在完全相同的时间获取图像或其他数据。 有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化 等）。