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公开(公告)号：US09133187B2
公开(公告)日：2015-09-15
申请号：US14002079
申请日：2012-02-28
申请人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwarz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky , Steven Boyd
发明人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwarz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky , Steven Boyd
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D471/04 , C07D491/052 , A61K45/06
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要： Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译： 具有式I的化合物，其中Z，Z 1 Z 2 Z 3，R 3a，R 3b和R b如本文所定义是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US20150087664A1
公开(公告)日：2015-03-26
申请号：US14237143
申请日：2012-08-03
申请人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwartz , Christopher S. Siedem , Eli M. Wallace
发明人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwartz , Christopher S. Siedem , Eli M. Wallace
IPC分类号： C07D405/14 , C07D403/12
CPC分类号： C07D405/14 , C07D403/12
摘要： Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译： 具有式（I）的化合物，其中本文定义的R1，R2，R3和Ar是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US20130045286A1
公开(公告)日：2013-02-21
申请号：US13425186
申请日：2012-03-20
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61P35/00 , A61K31/498 , A61K31/7068 , A61K31/4745 , A61K33/24 , A61K31/513 , A61K31/444 , A61K31/501
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：US08178131B2
公开(公告)日：2012-05-15
申请号：US12992468
申请日：2009-05-13
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K33/24 , A61K31/437 , A61K31/7068 , A61K31/4745 , A61K31/513 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/498 , A61K31/5377 , A61K31/55 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式（I）的化合物可用于抑制CHK1和/或CHK2。 公开了使用式（I）化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US09187462B2
公开(公告)日：2015-11-17
申请号：US14237143
申请日：2012-08-03
申请人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwarz , Christopher S. Siedem , Eli M. Wallace
发明人： James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwarz , Christopher S. Siedem , Eli M. Wallace
IPC分类号： A61K31/517 , C07D239/84 , C07D405/14 , C07D403/12
CPC分类号： C07D405/14 , C07D403/12
摘要： Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译： 具有式（I）的化合物，其中本文定义的R1，R2，R3和Ar是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US08545897B2
公开(公告)日：2013-10-01
申请号：US13425186
申请日：2012-03-20
申请人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
发明人： Yvan Le Huerou , James F. Blake , Indrani W. Gunwardana , Pete Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC分类号： A61K31/4545 , A61K31/437 , A61K31/497 , A61K31/506 , A61K33/24 , A61K31/513 , A61K31/444 , A61K31/501 , A61P35/00
CPC分类号： C07D471/04 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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