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公开(公告)号:US09187462B2
公开(公告)日:2015-11-17
申请号:US14237143
申请日:2012-08-03
申请人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwarz , Christopher S. Siedem , Eli M. Wallace
发明人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwarz , Christopher S. Siedem , Eli M. Wallace
IPC分类号: A61K31/517 , C07D239/84 , C07D405/14 , C07D403/12
CPC分类号: C07D405/14 , C07D403/12
摘要: Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译: 具有式(I)的化合物,其中本文定义的R1,R2,R3和Ar是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号:US20150087664A1
公开(公告)日:2015-03-26
申请号:US14237143
申请日:2012-08-03
申请人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwartz , Christopher S. Siedem , Eli M. Wallace
发明人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Ferdinand Garrey , John Gaudino , Lewis Gazzard , Robert J. Kaus , Samuel Kintz , Peter J. Mohr , David A. Moreno , Jacob Schwartz , Christopher S. Siedem , Eli M. Wallace
IPC分类号: C07D405/14 , C07D403/12
CPC分类号: C07D405/14 , C07D403/12
摘要: Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译: 具有式(I)的化合物,其中本文定义的R1,R2,R3和Ar是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号:US09133187B2
公开(公告)日:2015-09-15
申请号:US14002079
申请日:2012-02-28
申请人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwarz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky , Steven Boyd
发明人: James F. Blake , Huifen Chen , Mark Joseph Chicarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwarz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky , Steven Boyd
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00 , C07D471/04 , C07D491/052 , A61K45/06
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要: Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译: 具有式I的化合物,其中Z,Z 1 Z 2 Z 3,R 3a,R 3b和R b如本文所定义是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号:US20130338140A1
公开(公告)日:2013-12-19
申请号:US14002079
申请日:2012-02-28
申请人: James F. Blake , Huifen Chen , Mark Joseph Chcarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwartz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky
发明人: James F. Blake , Huifen Chen , Mark Joseph Chcarelli , Jason Demeese , Rustam Garrey , John J. Gaudino , Robert J. Kaus , Gabrielle R. Kolakowski , Allison L. Marlow , Peter J. Mohr , Li Ren , Jacob Schwartz , Christopher S. Siedem , Allen A. Thomas , Eli Wallace , Steven Mark Wenglowsky
IPC分类号: C07D471/04 , A61K45/06 , A61K31/519
CPC分类号: C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要: Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
摘要翻译: 具有式I的化合物,其中Z,Z 1 Z 2 Z,R 3a,R 3b和R b如本文所定义,是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号:US07932277B2
公开(公告)日:2011-04-26
申请号:US12118624
申请日:2008-05-09
申请人: Scott Seiwert , Steven W. Andrews , Leonid Beigelman , Lawrence M. Blatt , Brad Buckman , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timothy S. Kercher , Michael A. Lyon , Bin Wang
发明人: Scott Seiwert , Steven W. Andrews , Leonid Beigelman , Lawrence M. Blatt , Brad Buckman , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timothy S. Kercher , Michael A. Lyon , Bin Wang
IPC分类号: A61K31/4035 , A61K31/428 , A61K31/4025 , A61K31/401 , C07D207/09 , C07D403/12 , C07D417/12
CPC分类号: C07D217/26 , C07D401/12 , C07D417/14
摘要: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译: 实施方案提供了通式I的化合物,以及包含主题化合物的组合物,包括药物组合物。 实施方案提供了通式II的化合物,以及包含主题化合物的组合物,包括药物组合物。 实施方案还提供治疗方法,包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法,所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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公开(公告)号:US20090297476A1
公开(公告)日:2009-12-03
申请号:US12118624
申请日:2008-05-09
申请人: SCOTT SEIWERT , STEVEN W. ANDREWS , LEONID BEIGELMAN , LAWRENCE M. BLATT , BRAD BUCKMAN , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timonthy S. Kercher , Michael A. Lyon , Bin Wang
发明人: SCOTT SEIWERT , STEVEN W. ANDREWS , LEONID BEIGELMAN , LAWRENCE M. BLATT , BRAD BUCKMAN , Kevin R. Condroski , Yutong Jiang , Robert J. Kaus , April L. Kennedy , Timonthy S. Kercher , Michael A. Lyon , Bin Wang
IPC分类号: A61K38/21 , C12N9/99 , A61K31/7088 , A61K31/5377 , A61K31/4439 , A61K31/427 , C07D413/14 , C07D417/14
CPC分类号: C07D217/26 , C07D401/12 , C07D417/14
摘要: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译: 实施方案提供了通式I的化合物,以及包含主题化合物的组合物,包括药物组合物。 实施方案提供了通式II的化合物,以及包含主题化合物的组合物,包括药物组合物。 实施方案还提供治疗方法,包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法,所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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