公开(公告)号：US20060063768A1

公开(公告)日：2006-03-23

申请号：US10505777

申请日：2003-02-24

申请人： Thomas Mueller ,  Rudolf Moser ,  Martin Ulmann

发明人： Thomas Mueller ,  Rudolf Moser ,  Martin Ulmann

IPC分类号： A61K31/525

CPC分类号： A61K45/06 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/525 ,  A61K31/714 ,  A61K2300/00

摘要： This invention relates to the use of folates for producing a pharmaceutical preparation suitable for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing the inflammation markers C-reactive protein (CRP) and serum amyloid A protein (SAA). The clinical areas of application are all anomalies of the CRP and SM levels. The invention also relates to pharmaceutical preparations for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing CRP and SM levels, characterised in that as an active ingredient it comprises at least one compound which is selected from the group consisting of pteroic acid monoglutamate (folic acid), dihydrofolic acid, 5-formyltetrahydrofolic acid, 5-methyltetrahydrofolic acid, 5,10-methylenetetrahydrofolic acid, 5,10-methenyl-tetrahydrofolic acid, 10-formyltetrahydrofolic acid or tetrahydrofolic acid, polyglutamates thereof, optical isomers thereof, particularly optically pure natural isomers thereof, and mixtures of optical isomers also, particularly racemic mixtures, as well as pharmaceutically acceptable salts thereof also, together with pharmaceutically acceptable active ingredients and adjuvants.

摘要翻译： 本发明涉及叶酸用于制备适于预防和治疗炎症及与炎症有关的疾病的药物制剂的用途，特别是用于影响炎症标记物C反应蛋白（CRP）和血清淀粉样蛋白A蛋白（SAA）。 临床应用领域都是CRP和SM水平的异常。 本发明还涉及用于预防和治疗炎症以及与炎症有关的疾病，特别是用于影响CRP和SM水平的药物制剂，其特征在于作为活性成分，其包含至少一种选自以下的化合物： 戊酸单谷氨酸（叶酸），二氢叶酸，5-甲酰四氢叶酸，5-甲基四氢叶酸，5,10-亚甲基四氢叶酸，5,10-甲基四氢叶酸，10-甲酰四氢叶酸或四氢叶酸，聚谷氨酸，旋光异构体 ，特别是光学纯的天然异构体，以及光学异构体的混合物，特别是外消旋混合物，以及其药学上可接受的盐，以及药学上可接受的活性成分和佐剂。

公开(公告)号：US20060053974A1

公开(公告)日：2006-03-16

申请号：US11226192

申请日：2005-09-09

申请人： Edgar Blust ,  Thomas Mueller

发明人： Edgar Blust ,  Thomas Mueller

IPC分类号： B67B7/00

CPC分类号： A61B17/162 ,  A61B2017/0046 ,  A61C1/142 ,  B23B31/008

摘要： In order to simplify the insertion of the tool in the case of a coupling for a surgical rotary drive hand piece including a tool which is mounted in the hand piece and driven thereby in rotary manner and incorporating a sleeve-shaped, rotary driven seating in the hand piece into which a shank of the tool is adapted to be inserted so as to form an interlocking rotary drive means, and including at least one locking body which is adapted to be inserted radially into the interior of the seating and which, in an inserted locking position, engages in a recess in the shank and thereby secures it from axial displacement, whereas, in a radially withdrawn position, it leaves the recess and thus enables an axial displacement of the shank in the seating, it is proposed that a driver having at least one contact surface on the side thereof facing the tool and which rotates with the sleeve and is axially displaceable with respect thereto be arranged in the sleeve-shaped seating for the purposes of forming an interlocking rotary drive means, in that the driver is displaceable by the effect of a spring into a pushed-out position in which the locking body or bodies rest thereon and are thus held in their release position, in that the driver is displaceable by means of the shank of the tool resting thereon against the effect of the spring into a pushed-in position in which the locking body or bodies enter the locking position and can secure the shank of the tool from axial displacement, and in that the shank of the tool in the pushed-in position thereof secured from axial displacement by the locking body or bodies pushes the driver against the effect of the spring into the seating in such a manner that its contact surfaces rest against the contact surfaces of the tool so as to form a rotary drive means.

摘要翻译： 为了简化在用于手术旋转驱动手柄的联接器的情况下的工具的插入，所述外科旋转驱动手柄包括安装在手持件中并由此以旋转方式驱动的工具，并且将套筒形的旋转从动座部 手柄，其中工具的柄适于插入其中，以形成互锁的旋转驱动装置，并且包括至少一个锁定体，其适于径向插入到座椅的内部，并且在插入 锁定位置，接合在柄部中的凹部，从而使其不被轴向移动，而在径向撤回的位置，其离开凹部，从而使得柄在座椅中的轴向位移，建议具有 其侧面上的至少一个接触表面面向工具，并且与套筒一起旋转并且可相对于该套筒轴向移位以布置在套筒形座中以用于fo 联锁旋转驱动装置，其中驾驶员可通过弹簧的作用移位到被推出的位置，在该位置中，锁定体或身体搁置在其上并因此保持在其释放位置，因为驾驶员可以通过 抵靠弹簧的作用抵靠在其中锁定体或身体进入锁定位置并且可以将工具的柄部固定在轴向位移上的推入位置的工具的柄上的装置的手段， 通过锁定体或身体从轴向位移固定的推入位置中的工具将弹簧抵抗弹簧的作用以使其接触表面抵靠工具的接触表面的方式推动，以便 形成旋转驱动装置。

公开(公告)号：US20050049946A1

公开(公告)日：2005-03-03

申请号：US10893872

申请日：2004-07-20

申请人： Thomas Mueller ,  Jurgen Kohling

发明人： Thomas Mueller ,  Jurgen Kohling

IPC分类号： G06Q30/00 ,  G06F17/60

CPC分类号： G06Q20/14 ,  G06Q30/04

摘要： Methods and systems are provided for processing one or more bills of a biller. Methods and systems may present a request to pay one or more of a set of one or more bills in total or in part on a site of a computer network, A selection of the one or more bills from a customer may be received, said selection responding to said request via said site. Method and system may generate an electronic advice of settlement of the selected bills comprising an ID, and present the electronic advice of settlement and/or the ID to the customer or to a payment service provider.

摘要翻译： 提供了用于处理一个或多个账单的账单的方法和系统。 方法和系统可以呈现一个总计或部分地在计算机网络的站点上支付一个或多个票据中的一个或多个的请求。可以接收来自客户的一个或多个票据的选择，所述选择 通过所述站点响应所述请求。 方法和系统可以生成包括ID的所选票据的结算的电子建议，并向客户或支付服务提供商呈现结算和/或ID的电子建议。

公开(公告)号：US20050015513A1

公开(公告)日：2005-01-20

申请号：US10621486

申请日：2003-07-16

申请人： Luu Tran ,  Jeffrey Blattman ,  Thomas Mueller ,  Su-Chong Myong

发明人： Luu Tran ,  Jeffrey Blattman ,  Thomas Mueller ,  Su-Chong Myong

IPC分类号： H04L12/28 ,  H04L29/08 ,  H04W8/22 ,  H04W28/18 ,  G06F15/16

CPC分类号： H04W8/22 ,  H04L67/04 ,  H04L67/2823 ,  H04L67/2838 ,  H04L67/303 ,  H04L69/329 ,  H04W28/18

摘要： A method and system for storing and retrieving extensible multi-dimensional display property configurations. In one embodiment, a method is disclosed for the display of content that is configurable to a variety of contextual environments by reading a plurality of settings that are associated with an electronic device requesting content. The plurality of settings defines the contextual environment of the electronic device. The method continues by incorporating the plurality of settings as values in the list of filter criteria. The list of filter criteria is organized in a hierarchical order and specifies the format within which to present the content to be displayed at the electronic device. Thereafter, the method continues by matching the list of filter criteria with a resource to be displayed with the content. The resource is retrieved from memory for ultimate delivery to the electronic device for display.

摘要翻译： 一种用于存储和检索可扩展多维显示属性配置的方法和系统。 在一个实施例中，公开了一种用于通过读取与请求内容的电子设备相关联的多个设置来显示可配置为各种上下文环境的内容的方法。 多个设置定义电子设备的上下文环境。 该方法通过将多个设置值作为过滤器标准列表中的值来继续。 过滤器标准列表以分级顺序组织，并指定呈现要在电子设备上显示的内容的格式。 此后，该方法通过将过滤标准的列表与要与内容一起显示的资源进行匹配来继续。 从存储器检索资源以最终传送到电子设备进行显示。

公开(公告)号：US06546183B2

公开(公告)日：2003-04-08

申请号：US09862105

申请日：2001-05-21

申请人： Lothar Finzel ,  Ernst Mayr ,  Thomas Mueller ,  Heinz Diermeier

发明人： Lothar Finzel ,  Ernst Mayr ,  Thomas Mueller ,  Heinz Diermeier

IPC分类号： G02B636

CPC分类号： E01F11/00 ,  G02B6/00 ,  G02B6/504

摘要： To protect a waveguide or cable in an installation channel, a protective profile is inserted into the channel and has a substantially U-shaped cross-section when installed. To install this in the channel, an apparatus having a drum with a profile wound thereon has the profile unwound and guided by guide rolls to a press roll, which presses the profile into the channel to the desired depth. The profile can have a center portion provided with embedded reinforcing elements or even optical or electrical leads.

摘要翻译： 为了保护安装通道中的波导或电缆，保护型材插入通道中，并且在安装时具有大致U形的横截面。 为了将其安装在通道中，具有卷绕在其上的轮廓的滚筒的设备具有退绕并由导向辊引导到压榨辊的轮廓，压榨辊将轮廓压入通道到期望的深度。 轮廓可以具有设置有嵌入的加强元件或甚至光学或电引线的中心部分。

公开(公告)号：US06483450B2

公开(公告)日：2002-11-19

申请号：US09880215

申请日：2001-06-13

申请人： Konrad Boehm ,  Johann-Friedrich Luy ,  Thomas Mueller

发明人： Konrad Boehm ,  Johann-Friedrich Luy ,  Thomas Mueller

IPC分类号： H03M166

CPC分类号： H03M1/662

摘要： A method for digital-to-analog conversion of a digital signal (xd(ti)) comprises resolving the signal (xd(ti)) in the time region into intervals and successively transforming these intervals on the basis of orthogonal functions (gjd(t)). Coefficients (ajd) associated with the orthogonal functions (gjd(t)) are determined and converted from digital to analog and the signal (xa(t)) is transformed back in the analog region on the basis of analog coefficients (aj), which result therefrom, by means of orthogonal functions (hj(t)).

摘要翻译： 一种用于数字信号（xd（ti））的数模转换的方法包括将时区中的信号（xd（ti））分解为间隔，并且基于正交函数（gjd（t ））。 确定与正交函数（gjd（t））相关联的系数（ajd）并将其从数字转换为模拟，并且基于模拟系数（aj）将信号（xa（t））变换回模拟区域，其中 通过正交函数（hj（t））得到。

公开(公告)号：US06236798B1

公开(公告)日：2001-05-22

申请号：US09260906

申请日：1999-03-02

申请人： Lothar Finzel ,  Ernst Mayr ,  Thomas Mueller ,  Heinz Diermeier

发明人： Lothar Finzel ,  Ernst Mayr ,  Thomas Mueller ,  Heinz Diermeier

IPC分类号： G02B636

CPC分类号： E01F11/00 ,  G02B6/00 ,  G02B6/504

摘要： To protect a waveguide or cable in an installation channel, a protective profile is inserted into the channel and has a substantially U-shaped cross-section when installed. To install this in the channel, an apparatus having a drum with a profile wound thereon has the profile unwound and guided by guide rolls to a press roll, which presses the profile into the channel to the desired depth. The profile can have a center portion provided with embedded reinforcing elements or even optical or electrical leads.

公开(公告)号：US06209710B1

公开(公告)日：2001-04-03

申请号：US09180669

申请日：1999-02-16

申请人： Thomas Mueller ,  Ernst Kuenzler

发明人： Thomas Mueller ,  Ernst Kuenzler

IPC分类号： B65G4784

CPC分类号： B65G17/323 ,  B65G47/31 ,  B65G51/035 ,  B65G2201/02 ,  B65G2201/0244 ,  B65G2201/0247

摘要： The conveying method comprises a flying takeover of containers (1) being fed into a takeover area (U.1) in a container stream, hanging conveyance of the containers along a conveying path (FS) with a freely selectable course and delivery of the containers in a delivery area (U.2). For taking over the containers, a sequence of individual and equidistant holding means (5) is supplied to the takeover area (U.1) along a descending curved path (7′) joining a container feeding path (8) tangentially at the end of the takeover area (U.1) and the holding means (5) are introduced into the container stream each between two containers (1). At the beginning of this introduction, the holding means have a speed (v′) greater than the container speed (v) and during introduction they are decelerated to the container speed (v). Thereby, the feeding of containers and holding means is matched such that each holding means (5) reaches the container feeding speed (v) when it encircles the container downstream, i.e. when it is in an at least potential holding position relative to this container. At the latest in the delivery area, the holding means are turned by 180° around a vertical axis such that for delivery the containers to a container removing means (11), the holding means (5) can be conveyed away along an upward curved path. The curved path of the holding means in the takeover area (U.1) and/or in the delivery area (U.2) may also be realized by individual pivoting of the holding means (5).

摘要翻译： 输送方法包括将容器（1）的飞行收取物送入容器流中的收容区域（U.1）中，沿着输送路径（FS）悬挂容器的输送，可自由选择的路线和容器的输送 在交付区域（U.2）。 为了接收容器，将一系列单独和等距的保持装置（5）沿着下降的弯曲路径（7'）提供给接收区域（U.1），该下降弯曲路径（7'）将容器进给路径（8） 收纳区域（U.1）和保持装置（5）被引入到两个容器（1）之间的容器流中。 在该介绍开始时，保持装置具有大于容器速度（v）的速度（v'），并且在引入期间它们减速到容器速度（v）。 因此，容器和保持装置的供给是匹配的，使得每个保持装置（5）在其围绕容器下游即即当其相对于该容器处于至少潜在的保持位置时达到容器进给速度（v）。 最近在交货区域中，保持装置围绕垂直轴转动180度，以便将容器运送到容器移除装置（11），保持装置（5）可沿着向上弯曲的路径 。 收纳区域（U.1）和/或输送区域（U.2）中的保持装置的弯曲路径也可以通过保持装置（5）的单独枢转来实现。

公开(公告)号：US5455348A

公开(公告)日：1995-10-03

申请号：US173603

申请日：1993-12-23

申请人： Volkhard Austel ,  Wolfgang Eisert ,  Frank Himmelsbach ,  Guenter Linz ,  Thomas Mueller ,  Helmut Pieper ,  Johannes Weisenberger

发明人： Volkhard Austel ,  Wolfgang Eisert ,  Frank Himmelsbach ,  Guenter Linz ,  Thomas Mueller ,  Helmut Pieper ,  Johannes Weisenberger

IPC分类号： A61K31/44 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/55 ,  A61P7/02 ,  A61P9/10 ,  A61P35/00 ,  C07D207/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D521/00

CPC分类号： C07D207/26 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

摘要： The invention relates to cyclic imino derivatives of general formulaB--X.sub.5 --X.sub.4 --X.sub.3 --X.sub.2 --X.sub.1 --A--Y--E(I)whereinA, B, E, X.sub.2 to X.sub.5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.

摘要翻译： 本发明涉及通式B-X5-X4-X3-X2-X1-AYE（Ⅰ）的环亚氨基衍生物，其中A，B，E，X 2至X 5和Y如权利要求1中所定义，立体异构体，互变异构体， 特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的药理学性质，优选聚集抑制作用，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：US5418233A

公开(公告)日：1995-05-23

申请号：US961135

申请日：1992-10-14

申请人： Guenter Linz ,  Helmut Pieper ,  Frank Himmelsbach ,  Austel: Volkhard ,  Thomas Mueller ,  Johannes Weisenberger ,  Elke Seewaldt-Becker

发明人： Guenter Linz ,  Helmut Pieper ,  Frank Himmelsbach ,  Austel: Volkhard ,  Thomas Mueller ,  Johannes Weisenberger ,  Elke Seewaldt-Becker

IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  C07D213/75 ,  C07D213/81 ,  C07D237/14 ,  C07D237/20 ,  C07D237/24 ,  C07D239/28 ,  C07D239/34 ,  C07D239/36 ,  C07D241/20 ,  C07D401/06 ,  C07D401/12 ,  C07D417/12 ,  C07F9/40 ,  C07F9/6509

CPC分类号： C07D239/36 ,  C07D237/14 ,  C07D237/20 ,  C07D237/24 ,  C07D401/06 ,  C07D401/12 ,  C07F9/650941

摘要： Heterobiaryl derivatives of the formulaR.sub.1 NH--X.sub.1 --X.sub.2 --X.sub.3 --Y.sub.1 --Y.sub.2 --Y.sub.3 --Y.sub.4 --E (I)whereinR.sub.1, X.sub.1 to X.sub.3 and Y.sub.1 to Y.sub.4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologically acceptable salts, thereof with organic or inorganic acids or bases. The derivatives have valuable pharmacological properties, such as inhibiting cell-cell aggregation and cell-matrix interactions.

摘要翻译： 式R1NH-X1-X2-X3-Y1-Y2-Y3-Y4-E（Ⅰ）的杂芳基衍生物其中R1，X1至X3和Y1至Y4如本文所定义，互变异构体，立体异构体及其混合物，以及 盐，特别是其生理上可接受的盐与有机或无机酸或碱反应。 该衍生物具有有价值的药理学性质，例如抑制细胞 - 细胞聚集和细胞 - 基质相互作用。