公开(公告)号：US07670553B2

公开(公告)日：2010-03-02

申请号：US11087809

申请日：2005-03-24

申请人： Arthur L. Babson

发明人： Arthur L. Babson

IPC分类号： G01N35/02

CPC分类号： G01N35/025 ,  G01N35/00693 ,  G01N35/0095 ,  G01N35/026 ,  G01N2035/00574 ,  G01N2035/00752 ,  G01N2035/00782 ,  G01N2035/0444 ,  G01N2035/0465 ,  Y10T436/113332

摘要： An automated chemical or biological sample analyzer includes a plurality of linear sample carrying racks that are moved to a processing station for conducting an analysis using one or more carousel devices. Under computer control, rotational movements of the carousel or carousels, linear movements of the transfer or shuttle mechanisms, and operation of a pipetting station are performed in a coordinated fashion so as to handle the processing of a large number of samples simultaneously in an optimized fashion that allows random ordering of samples for processing.

摘要翻译： 自动化学或生物样品分析仪包括多个线性样品携带架，其移动到处理站，以使用一个或多个转盘装置进行分析。 在计算机控制下，圆盘传送带或转盘的旋转运动，传送或梭机构的线性运动和移液站的操作以协调的方式执行，以便以优化的方式同时处理大量样品 这允许样品的随机排序进行处理。

公开(公告)号：US06417008B2

公开(公告)日：2002-07-09

申请号：US09845304

申请日：2001-05-01

申请人： William Tyberg ,  Arthur L. Babson

发明人： William Tyberg ,  Arthur L. Babson

IPC分类号： G01N110

CPC分类号： G01N35/1011 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/12 ,  Y10T436/2575

摘要： A pipetting station having a bottom sensing device is provided in conjunction with one of any known liquid level sensing devices. The bottom sensing device includes a pipetting probe spring mounted to a pipetting arm of the pipetting station. The bottom sensing device also includes a sensor for determining when a pipetting tip of the pipetting probe is in contact with a bottom of a tube. The bottom sensing device permits the pipetting probe to measure an exact volume of fluid in the tube by allowing the pipetting tip to be lowered to the bottom of the tube beyond the sensed fluid level.

摘要翻译： 具有底部感测装置的移液站与任何已知的液位感测装置中的任何一个结合提供。 底部感测装置包括安装到移液站的移液臂的移液探头弹簧。 底部感测装置还包括传感器，用于确定移液探针的移液末端何时与管的底部接触。 底部感测装置允许移液探针通过允许移液针头降低到超过感测到的液位的管的底部来测量管中的流体的精确体积。

公开(公告)号：US5318748A

公开(公告)日：1994-06-07

申请号：US681943

申请日：1991-04-08

申请人： Arthur L. Babson ,  John E. Underwood

发明人： Arthur L. Babson ,  John E. Underwood

IPC分类号： G01N33/53 ,  G01N33/544

CPC分类号： G01N33/5304

摘要： A centrifuge vessel (10) for performing automated immunoassays is disclosed. The centrifuge vessel (10) comprises a center tube (11) and an outer waste chamber (15). A biomaterial (18) is held within the center tube (11) and is capable of binding specific analytes in test samples. In operation, the centrifuge vessel (10) is rotated at high speed about its longitudinal axis, thereby causing all fluid within the center tube (11) to be transported into the outer waste chamber (15) while the analyte of interest remains bound to the biomaterial (18) positioned within the center tube (11).

摘要翻译： 公开了一种用于进行自动化免疫测定的离心机容器（10）。 离心机容器（10）包括中心管（11）和外部废物室（15）。 生物材料（18）保持在中心管（11）内，并且能够结合测试样品中的特定分析物。 在操作中，离心机容器（10）围绕其纵向轴线以高速旋转，从而使得中心管（11）内的所有流体被输送到外部废物室（15）中，而感兴趣的分析物保持与 位于中心管（11）内的生物材料（18）。

公开(公告)号：US5258309A

公开(公告)日：1993-11-02

申请号：US779845

申请日：1991-10-21

申请人： Arthur L. Babson ,  John E. Underwood

发明人： Arthur L. Babson ,  John E. Underwood

IPC分类号： G01N33/53 ,  G01N35/00 ,  G01N30/96

CPC分类号： G01N33/5304 ,  B01L3/5021 ,  B01L2300/0854 ,  Y10T436/111666

摘要： A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed by flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.

摘要翻译： 公开了以自动方式进行免疫测定的方法。 被测试的生物流体放置在其中具有固体支持物（18）的管（11）中，生物流体中的特定分析物将被选择性地结合到该管（11）上。 在生物流体中的分析物与固体支持物（18）结合后，管（11）围绕其纵向轴线以高速旋转，使得生物流体在管（11）的内壁向上传送 打开终端（16），并进入废物室（15）。 具有结合的分析物的固体支持物（18）可以通过用水或其它合适的流体冲洗管（11）的内部并且以围绕其纵向轴线的高速旋转来容易地洗涤。

公开(公告)号：US5098845A

公开(公告)日：1992-03-24

申请号：US552132

申请日：1990-07-13

申请人： Arthur L. Babson

发明人： Arthur L. Babson

IPC分类号： G01N33/53

CPC分类号： G01N33/5304 ,  B01L3/5021 ,  B01L2300/0854 ,  Y10T436/111666

摘要： A method for conducting immunoassays in an automated fashion is disclosed. A biological fluid under test is placed in a tube (11) which has a solid support (18) therein to which a specific analyte in the biological fluid will be selectively bound. After the analyte in the biological fluid is bound to the solid support (18), the tube (11) is rotated at high speed about its longitudinal axis causing the biological fluid to be transported up the inside walls of tube (11), over the open terminal end (16), and into waste chamber (15). The solid support (18) with the bound analyte may easily be washed byl flushing the inside of tube (11) with water or other suitable fluids and rotating the tube (11) at high speed about its longitudinal axis.

摘要翻译： 公开了以自动方式进行免疫测定的方法。 被测试的生物流体放置在其中具有固体支持物（18）的管（11）中，生物流体中的特定分析物将被选择性地结合到该管（11）上。 在生物流体中的分析物与固体支持物（18）结合后，管（11）围绕其纵向轴线以高速旋转，使得生物流体在管（11）的内壁向上传送 打开终端（16），并进入废物室（15）。 具有结合的分析物的固体支持物（18）可以通过用水或其它合适的流体冲洗管（11）的内部而容易地洗涤，并且以高速绕其纵轴旋转管（11）。

公开(公告)号：US4559052A

公开(公告)日：1985-12-17

申请号：US581313

申请日：1984-02-17

申请人： Arthur L. Babson

发明人： Arthur L. Babson

IPC分类号： B01L3/00 ,  B65D47/20 ,  G01N27/416 ,  A61M3/00 ,  A61M5/00 ,  B65D41/34

CPC分类号： B01L3/505 ,  B65D47/2031 ,  G01N27/4165 ,  Y10S604/905

摘要： Disclosed is a uniquely simple, multiple use apparatus for the packaging of fluids, such as those reference fluids used for the calibration and standardization of blood gas instrumentation, which must not be exposed to air.

摘要翻译： 公开了用于包装流体的独特简单的多用途装置，例如用于血气仪器校准和标准化的参考流体，其不能暴露于空气中。

公开(公告)号：US4250041A

公开(公告)日：1981-02-10

申请号：US51779

申请日：1979-06-25

申请人： Arthur L. Babson ,  James E. Turner

发明人： Arthur L. Babson ,  James E. Turner

IPC分类号： A61K35/16 ,  C08B37/10 ,  A61K49/00 ,  G01N1/00

CPC分类号： C08B37/0075 ,  A61K35/16 ,  Y10T436/107497

摘要： This invention relates to a method for the removal of heparin from heparin-containing plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.

摘要翻译： 本发明涉及使用不溶性鱼精蛋白反应产物从含有肝素的血浆试验样品中除去肝素的方法，而不会不利地影响随后的血浆凝固时间的测试。 将硫酸鱼精蛋白或硫酸鱼精蛋白和血清白蛋白的组合与戊二醛交联以形成能够吸附肝素的不溶性反应产物。 根据本发明的方法，将过量的交联的鱼精蛋白反应产物加入到含有肝素的血浆样品中，并将混合物搅拌足以允许存在基本上所有肝素的吸附。 形成的不溶性鱼精蛋白肝素复合物与任何过量的不溶性鱼精蛋白反应产物一起从血浆中除去。 可以对无肝素血浆的等分试样进行凝血试验，以确定真正的凝血时间。

公开(公告)号：US4078552A

公开(公告)日：1978-03-14

申请号：US589227

申请日：1975-06-23

申请人： Evan N. Chen ,  Arthur L. Babson

发明人： Evan N. Chen ,  Arthur L. Babson

IPC分类号： A61B17/3211 ,  A61B5/15 ,  A61B5/151 ,  A61B17/32 ,  A61B5/02

CPC分类号： A61B17/32093 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150259 ,  A61B5/150343 ,  A61B5/150458 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/15142

摘要： The specific disclosure provides a device and method of making an incision of precise dimensions in a patient, preferably in the forearm, and determining exact bleeding from initial puncture of the skin until the flow of blood has ceased, i.e. hemostatis is complete. The device comprises a housing including a blade aperture at one end thereof adapted to be positioned in abutting engagement with the skin of the subject. A spring member and a blade member having at least one cutting edge are located in the housing. Means are also provided in the housing and is connected to the blade member for retracting the blade member inwardly from the blade aperture and against the bias of the spring member. Manually operable means are provided for releasably engaging the retracting means to maintain the blade member in a retracted position against the bias of the spring member until the device is ready for use. The engaging means is manually operable to irretrievably disengage the retracting means, thereby permitting the retracting means and the blade member to move under the bias of the spring member to position the at least one cutting edge a predetermined distance outwardly from the blade aperture.

摘要翻译： 具体公开内容提供了一种在患者，优选在前臂中进行切割精确尺寸的装置和方法，并且确定皮肤初始穿刺的准确渗血，直到血液流动已经停止，即止血完成。 该装置包括壳体，该壳体在其一端处包括适于被定位成与被检体的皮肤邻接接合的刀片孔。 具有至少一个切削刃的弹簧构件和刀片构件位于壳体中。 装置还设置在壳体中并且连接到叶片构件，用于使叶片构件从叶片孔向内取回并抵抗弹簧构件的偏压。 提供手动操作的装置，用于可释放地接合回缩装置，以克服弹簧构件的偏压将叶片构件保持在缩回位置，直到装置准备使用。 接合装置是可手动操作的，以不可恢复地脱离收回装置，从而允许缩回装置和叶片构件在弹簧构件的偏压下移动，以将至少一个切割刃从刀片孔向外定位。