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公开(公告)号：US07029859B2
公开(公告)日：2006-04-18
申请号：US09797969
申请日：2001-03-05
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
IPC分类号： A61K39/395 , A61K49/00 , C07K1/00 , G01N33/53 , G01N33/567
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C07K14/705 , C12N2310/111 , C12N2310/3181
摘要： The present invention relates to methods for the diagnosis, evaluation and treatment of metastatic diseases using metastatic sequences, such as caveolin, to target metastatic cells. According to the methods of the present invention, certain cancers, including metastatic prostate cancer, may be treated by therapies which suppress expression of the caveolin gene. The present invention relates to biological technologies designed to block the activity of caveolin or the function of caveolae, including vector delivery of antisense caveolin sequences, the use of anti-caveolin antibodies, the use of promoters, and other approaches targeting the expression of caveolin.
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公开(公告)号：US06949109B2
公开(公告)日：2005-09-27
申请号：US10646968
申请日：2003-08-22
IPC分类号： A61B17/32
CPC分类号： A61B17/3211 , A61B17/3213 , A61B2017/32113
摘要： A surgical scalpel having a replaceable, spring-actuated, retractable cutting blade which may be locked in the operating or deployed position and returned to its safety position using a single digit on one hand.
摘要翻译： 外科手术刀具有可更换的弹簧致动的可缩回切割刀片，其可以锁定在操作或展开位置，并且一方面使用单个数字返回到其安全位置。
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公开(公告)号：USRE38392E1
公开(公告)日：2004-01-20
申请号：US09985799
申请日：2001-11-06
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
IPC分类号： C12N500
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2539/113
摘要： The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of at a primary site and incubated for a period of time sufficient for the cells to proliferate and develop metastases at secondary sites. Expressed sequences from cells at the primary and secondary sites are amplified by differential display polymerase chain reaction and compared. Differentially expressed sequences are identical identified and can be cloned and sequenced. These sequences can be used as probes in the diagnosis of metastatic disorders, as probes to isolate metastatic sequences and as a therapeutic agent.
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公开(公告)号：US20150037760A1
公开(公告)日：2015-02-05
申请号：US12939136
申请日：2010-11-03
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
CPC分类号： A61C9/0006 , A61C13/0004 , A61C13/0009 , A61C13/01 , A61C13/10 , A61C13/26 , A61C13/34 , G06F17/50
摘要： Systems and processes for the duplication of dentures from existing dentures. The interior and exterior of the dentures are scanned and a best fit procedure is used to create a fully digitized denture. The denture teeth are selected from a library that is the closest fit to the original denture teeth. The library teeth are offset a preset distance to compensate for the best fit. The teeth are then subtracted from the digitized denture. The margins of the denture are then cleaned after subtracting the teeth. The denture base is then ready for manufacturing. The teeth are then installed onto the denture base and provided to the patient.
摘要翻译： 现有假牙重复义齿的系统和过程。 扫描义齿的内部和外部，并使用最佳拟合程序来创建完全数字化的假牙。 义齿选自最接近原始义齿牙齿的图书馆。 图书馆牙齿偏移预设距离以补偿最佳拟合。 然后从数字化义齿中减去牙齿。 然后在减去牙齿后清洁义齿的边缘。 义齿底座然后准备制造。 然后将牙齿安装到义齿基座上并提供给患者。
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公开(公告)号：US08801431B2
公开(公告)日：2014-08-12
申请号：US13249210
申请日：2011-09-29
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
CPC分类号： A61C9/0006 , A61C13/0003 , A61C19/04
摘要： A combination tool for defining and measuring anatomical features of a patient for the fabrication of dentures. The tool includes components for preparing a double arch impression, for determining the vertical spacing of the patient's mouth, for measuring the lip, mid line and smile lines of the patient, and for determining the occlusal plane of the patient. This single tool replaces the need for a multitude of tools typically used in preparing for the fabrication of dentures.
摘要翻译： 用于定义和测量患者用于制造义齿的解剖特征的组合工具。 该工具包括用于准备双弓形印模的组件，用于确定患者口腔的垂直间距，用于测量患者的唇部，中线和微笑线以及用于确定患者的咬合面。 这种单一的工具代替了通常用于准备假牙制造的大量工具的需要。
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公开(公告)号：US07824685B2
公开(公告)日：2010-11-02
申请号：US11038285
申请日：2005-01-19
申请人： Timothy C. Thompson , Chengzhen Ren
发明人： Timothy C. Thompson , Chengzhen Ren
IPC分类号： A61K39/00
摘要： This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in normal mouse and human prostatic epithelial cells and primary tumors, but is significantly down regulated in metastatic mouse and human prostate cancer. In prostate cancer cells overexpression of the mouse RTVP-1 gene (mRTVP-1) induced apoptosis that was accompanied by increased caspase 8, 9 and 3 activities. mRTVP-1-stimulated apoptosis was also associated with increased levels of bax, bad and activated BID; reduced levels of bcl-2 and bcl-XL; and cytosolic cytochrome c accumulation. Adenoviral-vector-mediated mRTVP-1 expression lead to potent growth suppression and antimetastatic activities in an orthotopic mouse model of prostate cancer in vivo. These therapeutic activities were associated with anti-angiogenic effects and importantly a local and systemic immune response. Accordingly, p53 was linked with suppression of metastasis through its induction of mRTVP-1, which can concurrently induce apoptosis, suppress angiogenesis and stimulate an antitumor immune response. Thus, the invention includes compositions and methods, based on RTVP nucleic acid, polypeptides, and antibodies, for use in the treatment, prevention and detection of neoplastic disease and, specifically, metastatic prostatic neoplasia.
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公开(公告)号：USRE38490E1
公开(公告)日：2004-04-06
申请号：US09977371
申请日：2001-10-16
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
IPC分类号： A61K4800
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of at a primary site and incubated for a period of time sufficient for the cells to proliferate and develop metastases at secondary sites. Expressed sequences from cells at the primary and secondary sites are amplified by differential display polymerase chain reaction and compared. Differentially expressed sequences are identical identified and can be cloned and sequenced. These sequences can be used as probes in the diagnosis of metastatic disorders, as probes to isolate metastatic sequences and as a therapeutic agent.
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公开(公告)号：US5783182A
公开(公告)日：1998-07-21
申请号：US594031
申请日：1996-01-30
申请人： Timothy C. Thompson
发明人： Timothy C. Thompson
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of a primary site and incubated for a period of time sufficient for the cells to proliferate and develop metastases at secondary sites. Expressed sequences from cells at the primary and secondary sites are amplified by differential display polymerase chain reaction and compared. Differentially expressed sequences are identical and can be cloned and sequenced. These sequences can be used as probes in the diagnosis of metastatic disorders, as probes to isolate metastatic sequences and as a therapeutic agent.
摘要翻译： 本发明涉及用于鉴定转移序列的方法。 处理来自细胞系或动物组织的细胞以形成易于转移的细胞系。 将处理的细胞植入初级部位的动物中，并孵育足以使细胞在次级部位增殖和发展转移的时间。 通过差异显示聚合酶链反应扩增来自初级和次级位点的细胞的表达序列，并进行比较。 差异表达的序列是相同的，可以克隆和测序。 这些序列可用作诊断转移性疾病的探针，作为分离转移序列的探针和作为治疗剂。
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公开(公告)号：US5424192A
公开(公告)日：1995-06-13
申请号：US38491
申请日：1993-03-29
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/57434 , G01N33/57484 , Y10S436/813
摘要： This invention is directed to the identification, isolation and use of nonprostate derived markers, such as markers derived from the seminal vesicles, and antibodies which recognize these markers in the diagnosis of invasive proatic neoplasia, to diagnostic aids for screening biological samples for evidence of invasive prostatic neoplasia, and to methods for the use of these diagnostic aids.
摘要翻译： 本发明涉及鉴定，分离和使用非前列腺衍生标记物，例如来源于精囊的标志物，以及识别这些标志物在侵入性原发性肿瘤诊断中的抗体，用于筛选生物样品用于侵入性证据的诊断辅助物 前列腺增生症，以及使用这些诊断辅助工具的方法。
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